RESUMEN
PURPOSE: A neural network system was previously developed to rank a population in order of asthma probability based on responses to a postal questionnaire. Respondents ranked higher than a percentage point screening threshold are offered clinical review. The present study validates this system in a new population that had not been involved in system development. METHODS: The system was used to rank respondents to a community survey and to predict positive predictive value (PPV) for percentage point thresholds between the top 1% and 10% of the ranking. Respondents in the top 10% were invited for clinical review. Review information and expert opinion was used to designate respondents as clinically "asthmatic" or "non-asthmatic." PPV prediction for each threshold was compared with clinical status of respondents. RESULTS: As the threshold increased from 1% to 10%, the additional yield of clinical asthmatics decreased, indicating a ranking in asthma probability order (all 7 in the top 1% were clinical asthmatics compared with 91% of the top 5% and 83% of the top 10%). Percentages of clinical asthmatics were generally slightly higher than system PPV predictions. CONCLUSIONS: The system ranked the population in asthma probability order and estimated PPV conservatively, enabling health-care providers to predict resource implications of a screening program.
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Asma/epidemiología , Redes Neurales de la Computación , Humanos , Matemática , Encuestas y CuestionariosRESUMEN
BACKGROUND: There has been little available information regarding secular changes in the prevalence of respiratory symptoms since the mid-1990s. AIM: To examine changes in the prevalence of respiratory symptoms for 1993-2001. DESIGN OF STUDY: A series of postal questionnaire surveys. SETTING: Two general practice populations, including all age groups. METHOD: Four postal respiratory questionnaire surveys were conducted between 1993 and 2001. Subjects who replied to two or more surveys (8058 adults and 2350 children) were included in the main analyses. Validated scoring systems were used to define obstructive airways disease in adults and asthma in children. RESULTS: Over the 8-year observation period there were increases among adults in the crude prevalence of wheeze, being woken by cough, receipt of current asthma medication, and of obstructive airways disease, compared with decreases in children for wheeze, night cough, asthma attacks, and asthma. For adults, adjusted odds ratios per year of secular increase were 1.03 (95% confidence interval [CI] = 1.02 to 1.03) for wheeze, 1.03 (95% CI = 1.02 to 1.03) for being woken by cough, 1.03 (95% CI = 1.02 to 1.04) for asthma medication, and 1.02 (95% CI = 1.01 to 1.03) for obstructive airways disease. These increases were greater in those aged over 44 years, in males, and in those without a family history of asthma or a history of hayfever or eczema. Corresponding decreases for children were 0.94 (95% CI = 0.92 to 0.97) for wheeze, 0.93 (95% CI = 0.91 to 0.96) for night cough, 0.93 (95% CI = 0.90 to 0.95) for asthma attacks and 0.98 (95% CI = 0.95 to 1.00) for asthma. CONCLUSION: The increases found in adults are more likely to be due to chronic obstructive pulmonary disease (COPD) than asthma. This is supported by the decreases in symptom and asthma prevalence in children.
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Enfermedades Pulmonares Obstructivas/epidemiología , Trastornos Respiratorios/epidemiología , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Niño , Preescolar , Métodos Epidemiológicos , Medicina Familiar y Comunitaria/tendencias , Femenino , Humanos , Masculino , Persona de Mediana Edad , Prevalencia , Encuestas y Cuestionarios , Reino Unido/epidemiologíaRESUMEN
BACKGROUND: Identification and treatment of unrecognised asthmatics in the community is important for improving the health of the individual and minimising cost and quality of life burden. It is not practical to offer clinical diagnostic assessment to whole communities, and a simple tool such as a questionnaire is required to identify a smaller target group. Conventional questionnaire screening methods which separate individuals into positive and negative categories have resulted in large numbers of individuals requiring clinical assessment. This study has therefore developed and tested a weighted scoring system that prioritises those most urgently in need, based on their questionnaire responses. METHODS: A stratified random sample of adult respondents to a general practice postal questionnaire survey were categorised 'asthmatic' or 'non-asthmatic' according to three expert physicians' opinions. Based on this categorisation, logistic regression was used to derive weights reflecting the relative importance of each question in predicting asthma, allowing calculation of weighted scores reflecting likelihood of asthma. Respondents scoring higher than a chosen threshold would be offered diagnostic examination. RESULTS: Age and presence of wheeze were most influential (weight 3) and overall weighted scores ranged from -1 to 13. Positive predictive values (PPV) were estimated. For example, setting the threshold score at nine gave an estimated PPV for asthma diagnosis of 93.5%, a threshold score of seven corresponded to PPV 78.8%. PPV estimates were supported by examining 145 individuals from a new survey. CONCLUSION: Weighted scoring of questionnaire responses provides a method for evaluating the priority level of an individual 'at a glance', minimising the resource wastage of examining false positives.
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Asma/diagnóstico , Tamizaje Masivo/métodos , Encuestas y Cuestionarios , Adolescente , Adulto , Anciano , Asma/epidemiología , Asma/fisiopatología , Dolor en el Pecho/etiología , Tos/etiología , Disnea/etiología , Inglaterra/epidemiología , Femenino , Humanos , Modelos Logísticos , Masculino , Persona de Mediana Edad , Evaluación de Necesidades , Valor Predictivo de las Pruebas , Prevalencia , Ruidos Respiratorios/etiología , Índice de Severidad de la Enfermedad , FumarRESUMEN
BACKGROUND: Two simples scoring systems for a self-completed postal respiratory questionnaire were developed to identify adults who may have obstructive airways disease. The objective of this study was to validate these scoring systems. METHOD: A two-stage design was used. All adults in two practice populations were sent the questionnaire and a stratified random sample of respondents was selected to undergo full clinical evaluation. Three respiratory physicians reviewed the results of each evaluation. A majority decision was reached as to whether the subject merited a trial of obstructive airways disease medication. This clinical decision was compared with two scoring systems based on the questionnaire in order to determine their positive predictive value, sensitivity and specificity. RESULTS: The PPV (positive predictive value) of the first scoring system was 75.1% (95% CI 68.6-82.3), whilst that of the second system was 82.3% (95% CI 75.9-89.2). The more stringent second system had the greater specificity, 97.1% (95% CI 96.0-98.2) versus 95.3% (95% CI 94.0-96.7), but poorer sensitivity 46.9% (95% CI 33.0-66.8) versus 50.3% (95% CI 35.3-71.6). CONCLUSION: This scoring system based on the number of symptoms/risk factors reported via a postal questionnaire could be used to identify adults who would benefit from a trial of treatment for obstructive airways disease.
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Enfermedades Pulmonares Obstructivas/diagnóstico , Encuestas y Cuestionarios , Adulto , Humanos , Factores de Riesgo , Sensibilidad y EspecificidadRESUMEN
Acquired hemophilia A is a severe bleeding disorder caused by an autoantibody to factor VIII. Previous reports have focused on referral center patients and it is unclear whether these findings are generally applicable. To improve understanding of the disease, a 2-year observational study was established to identify and characterize the presenting features and outcome of all patients with acquired hemophilia A in the United Kingdom. This allowed a consecutive cohort of patients, unbiased by referral or reporting practice, to be studied. A total of 172 patients with a median age of 78 years were identified, an incidence of 1.48/million/y. The cohort was significantly older than previously reported series, but bleeding manifestations and underlying diseases were similar. Bleeding was the cause of death in 9% of the cohort and remained a risk until the inhibitor had been eradicated. There was no difference in inhibitor eradication or mortality between patients treated with steroids alone and a combination of steroids and cytotoxic agents. Relapse of the inhibitor was observed in 20% of the patients who had attained first complete remission. The data provide the most complete description of acquired hemophilia A available and are applicable to patients presenting to all centers.