Highly Luminescent and Ultrastable CsPbBr3 Perovskite Quantum Dots Incorporated into a Silica/Alumina Monolith.

We successfully prepared QDs incorporated into a silica/alumina monolith (QDs-SAM) by a simple sol-gel reaction of an Al-Si single precursor with CsPbBr3 QDs blended in toluene solution, without adding water and catalyst. The resultant transparent monolith exhibits high photoluminescence quantum yields (PLQY) up to 90 %, and good photostability under strong illumination of blue light for 300 h. We show that the preliminary ligand exchange of didodecyl dimethyl ammonium bromide (DDAB) was very important to protect CsPbBr3 QDs from surface damages during the sol-gel reaction, which not only allowed us to maintain the original optical properties of CsPbBr3 QDs but also prevented the aggregation of QDs and made the monolith transparent. The CsPbBr3 QDs-SAM in powder form was easily mixed into the resins and applied as color-converting layer with curing on blue light-emitting diodes (LED). The material showed a high luminous efficacy of 80 lm W-1 and a narrow emission with a full width at half maximum (FWHM) of 25 nm.

Enhancing the Stability of CH3NH3PbBr3 Quantum Dots by Embedding in Silica Spheres Derived from Tetramethyl Orthosilicate in "Waterless" Toluene.

Methylammonium lead halide perovskites suffer from poor stability because of their high sensitivity to moisture. Inorganic material coatings of SiO2 are preferred for coupling with perovskites to improve their stability, whereas the conventional SiO2 formation method is unsuitable because it requires water. Here, a simple SiO2 generation method based on the high hydrolysis rate of tetramethyl orthosilicate in analytical-grade toluene was developed to avoid the addition of water and catalyst. As a result, SiO2-encapsulated CH3NH3PbBr3 quantum dots (MAPB-QDs/SiO2) were fabricated without decreasing the quantum yield. Photostability tests indicated that the MAPB-QDs/SiO2 samples were markedly more stable than the unencapsulated MAPB-QDs. The photoluminescence (PL) of the MAPB-QDs/SiO2 powders was maintained at 94.10% after 470 nm LED illumination for 7 h, which was much higher than the remnant PL (38.36%) of the pure MAPB-QD sample under a relative humidity of 60%. Similar test results were observed when the MAPB-QDs/SiO2 powders were incorporated into the poly(methyl methacrylate) films. The enhanced photostability is ascribed to the SiO2 barriers protecting the MAPB-QDs from degradation.

Efficacy and safety of mirror therapy for post-stroke aphasia: A systematic review and meta-analysis protocol.

BACKGROUND: Aphasia is one of the most common complications of stroke. Mirror therapy (MT) is promising rehabilitation measure for the treatment of post-stroke aphasia. Although some studies suggested that MT is effective and safe for aphasia, the effects and safety remain uncertain due to lacking strong evidence, such as the relevant systematic review and meta- analysis. METHODS: This study will search PubMed, Web of Science, Cochrane Library, EMBASE, Medline, China Knowledge Network (CNKI), WANFANG, China Biomedical Literature Database (CBM), from inception to 1th May 2023 to identify any eligible study. No language or date of publication shall be limited. We will only include randomised controlled trials of MT in the Treatment of poststroke aphasia. Two investigators will work separately on the study selection, data extraction, and study quality assessment. The western aphasia battery (WAB) and aphasia quotient (AQ) will be included as the main outcomes. Boston diagnostic aphasia examination method (BDAE), Chinese standard aphasia examination (CRRCAE) will be included as the secondary outcomes. The statistical analysis will be conducted by RevMan V.5.4 software. The risk of bias of included studies will be assessed by the Cochrane 'Risk of bias' tool. The quality of proof of the results will be evaluated by using the Grading of Recommendations Assessment, Development and Evaluation guidelines. RESULTS: The finding will be presented in a journal or related conferences. CONCLUSION: This study will provide a basis for whether mirror therapy (MT) is effective and safe in the treatment of post-stroke aphasia. TRIAL REGISTRATION: Systematic review registration INPLASY registration number: INPLASY 202340054.

Acupuncture combined with mirror therapy for post-stroke dyskinesia: A meta-analysis and systematic review.

BACKGROUND: Dyskinesia is one of the most common complications of stroke. Acupuncture therapy (AT) and mirror therapy (MT) are promising rehabilitation measures for the treatment of post-stroke dyskinesia. Although some studies suggested that AT and MT are effective and safe for dyskinesia, the effects, and safety remain uncertain due to lacking strong evidence. The purpose of this study is to investigate the efficacy and safety of AT combined with MT in the treatment of post-stroke dyskinesia. METHODS: We searched the following databases: PubMed, Web of Science, Cochrane Library, EMBASE, Medline, China Knowledge Network, WANFANG, and China Biomedical Literature Database, from inception to 1 January 2023 to identify eligible studies. Total effective rate, the Fugl-Meyer assessment scale (FMA) upper and lower limb scores, modified Barthel index scores, Berg balance scale, modified Ashworth scale, and adverse reactions were adopted as outcome indicators. The Grading of Recommendations Assessment Development and Evaluation system was used by 2 independent reviewers to assess the quality of evidence for the outcome indicators included in the study. The statistical analysis was conducted by RevMan V.5.4 software. RESULTS: A total of 24 randomized controlled studies included 2133 patients with post-stroke dyskinesia were included. The total effective rate of AT combined with MT was more advantageous in the treatment of post-stroke dyskinesia (relative risk = 1.31, 95% confidence interval [CI] [1.22-1.42], Z = 6.96, P < .0001). AT combined with MT was more advantageous for FMA upper limb score (mean difference [MD] = 6.67, 95% CI [5.21-8.13], Z = 8.97, P < .00001) and FMA lower limb score (MD = 3.72, 95% CI [2.81-4.63], Z = 7.98, P < .00001). Meta-analysis showed that AT combined with MT for post-stroke dyskinesia had a more advantageous modified Barthel index score (MD = 9.51, 95% CI [7.44-11.58], Z = 9.01, P < .00001). CONCLUSION: AT combined with MT is effective in improving motor function and daily living ability of patients, especially in improving muscle spasms. However, these results should be regarded with caution given the low quality of evidence for the evaluation results.

A New Smart 2-Min Mobile Alerting Method for Mild Cognitive Impairment Due to Alzheimer's Disease in the Community.

The early identification of mild cognitive impairment (MCI) due to Alzheimer's disease (AD), in an early stage of AD can expand the AD warning window. We propose a new capability index evaluating the spatial execution process (SEP), which can dynamically evaluate the execution process in the space navigation task. The hypothesis is proposed that there are neurobehavioral differences between normal cognitive (NC) elderly and AD patients with MCI reflected in digital biomarkers captured during SEP. According to this, we designed a new smart 2-min mobile alerting method for MCI due to AD, for community screening. Two digital biomarkers, total mission execution distance (METRtotal) and execution distance above the transverse obstacle (EDabove), were selected by step-up regression analysis. For the participants with more than 9 years of education, the alerting efficiency of the combination of the two digital biomarkers for MCI due to AD could reach 0.83. This method has the advantages of fast speed, high alerting efficiency, low cost and high intelligence and thus has a high application value for community screening in developing countries. It also provides a new intelligent alerting approach based on the human-computer interaction (HCI) paradigm for MCI due to AD in community screening.

A new early warning method for mild cognitive impairment due to Alzheimer's disease based on dynamic evaluation of the "spatial executive process".

Objective: Mild cognitive impairment (MCI) due to Alzheimer's disease (AD), as an early stage of AD, is an important point for early warning of AD. Neuropathological studies have shown that AD pathology in pre-dementia patients involves the hippocampus and caudate nucleus, which are responsible for controlling cognitive mechanisms such as the spatial executive process (SEP). The aim of this study is to design a new method for early warning of MCI due to AD by dynamically evaluating SEP. Methods: We designed fingertip interaction handwriting digital evaluation paradigms and analyzed the dynamic trajectory of fingertip interaction and image data during "clock drawing" and "repetitive writing" tasks. Extracted fingertip interaction digital biomarkers were used to assess participants' SEP disorders, ultimately enabling intelligent diagnosis of MCI due to AD. A cross-sectional study demonstrated the predictive performance of this new method. Results: We enrolled 30 normal cognitive (NC) elderly and 30 MCI due to AD patients, and clinical research results showed that there may be neurobehavioral differences between the two groups in digital biomarkers captured during SEP. The early warning performance for MCI due to AD of this new method (areas under the curve (AUC) = 0.880) is better than that of the Minimum Mental State Examination (MMSE) neuropsychological scale (AUC = 0.856) assessed by physicians. Conclusion: Patients with MCI due to AD may have SEP disorders, and this new method based on dynamic evaluation of SEP will provide a novel human-computer interaction and intelligent early warning method for home and community screening of MCI due to AD.

Construction of bismuth-based porous carbon models by 3D printing technology for light-enhanced removal of chloride ions in wastewater.

The bismuth oxide (Bi2O3) based chloride (Cl-) removal method is one of the chemical precipitation methods possessing good selectivity and high removal efficiency of Cl- ions, but Bi2O3 often appears in the powder form, which is difficult to be recovered for regeneration. In this work, the combination of 3D printing technology and the Bi2O3 method was explored to construct the resin model including the Bi-precursors. In the optimum carbonization process at 400 °C for 30 min, the Bi3+ ions of the Bi-precursor were reduced into the metallic Bi0 nanoparticles, whose surfaces were covered by the thin Bi2O3 layers to form the heterostructured Bi0/Bi2O3 core/shell nanoparticles with an average size of 43 nm. These Bi0/Bi2O3 nanoparticles were tightly adhered to the internal and external surfaces of the hierarchical porous carbon model (Bi-PCM), which greatly facilitated their regeneration and ensured the stable Cl- removal performance. After five cycles of Cl- removal, the chloride removal efficiency over the multiple Bi-PCMs in the dark and pH 1 conditions maintained at about 26%, which then largely increased to 63.6% with UV light irradiation. The light-enhanced mechanism was related to the improved release rate of Bi3+ ions caused by photocorrosion and the Cl• radicals produced from the holes and the •OH and O2•- radicals, which quickly reacted with Bi2O3 to form BiOCl. The construction of Bi-PCMs by using 3D printing technology provides a very promising strategy for the removal of Cl- ions from wastewater.

Systematic Microwave-Assisted Postsynthesis of Mn-Doped Cesium Lead Halide Perovskites with Improved Color-Tunable Luminescence and Stability.

The metal doping at the Pb2+ position provides improved luminescence performance for the cesium lead halide perovskites, and their fabrication methods assisted by microwave have attracted considerable attention due to the advantages of fast heating and low energy consumption. However, the postsynthetic doping strategy of the metal-doped perovskites driven by microwave heating still lacks systematic research. In this study, the assembly of CsPbBr3/CsPb2Br5 with a strong fluorescence peak at 523 nm is used as the CsPbBr3 precursor, and through the optimization of the postsynthetic conditions such as reaction temperatures, Mn2+/Pb2+ feeding ratios, and Mn2+ sources, the optimum Mn2+-doped product (CsPb(Cl/Br)3:Mn) is achieved. The exciton fluorescence peak of CsPb(Cl/Br)3:Mn is blueshifted to 437 nm, and an obvious fluorescence peak attributing to the doped Mn2+ ions at 597 nm is obtained. Both the CsPbBr3 precursor and CsPb(Cl/Br)3:Mn have high PLQY and stability because there are CsPb2Br5 microcubic crystals to well disperse and embed the CsPbBr3 nanocrystals (NCs) in the precursor, and after Mn2+-doping, this structure is maintained to form CsPb(Cl/Br)3:Mn NCs on the surface of their microcrystals. The exploration of preparation parameters in the microwave-assisted method provides insights into the enhanced color-tunable luminescence of the metal-doped perovskite materials.

Moxibustion therapy on lumbar disc herniation: An evidence-based clinical practice guideline.

BACKGROUND: Lumbar disc herniation (LDH), as a disease with great disturbance to life and work, is known as the origin of the severe and disabling forms of nerve root pain. Recognized as an increasingly widely accepted treatment, the efficacy of moxibustion on LDH has been affirmed. However, clinical practice guidelines (CPG) for the treatment of LDH with moxibustion have not been developed. Therefore, we will carry out this work following the accepted methodological quality standards. METHODS: The new CPG will be developed according to the Institute of Medicine (IOM), the Appraisal of Guidelines for Research & Evaluation II (AGREE II) and WHO guideline handbook. And then determine recommendations based on high-level evidence. We will set up a Guideline Working Group and define clinical issues according to the PICO principles (Population, Intervention, Comparison, Outcomes). After evidence syntheses and several rounds of Delphi process, we will reach the consensus. In making the guideline, Patient values or preferences, results of peer review, and interest statements are all within the bounds of what we must consider. RESULTS: As the study is not yet complete, no results can be reported. CONCLUSION: So far, we will develop the first CPG for moxibustion of LDH strictly based on systematic methodologies in China. This CPG will establish the standard of LDH in moxibustion therapy. REGISTRATION NUMBER: IPGRP-2020CN034.

Efficient mercury removal in chlorine-free flue gas by doping Cl into Cu2O nanocrystals.

The low content of hydrogen chloride (HCl) in flue gas is difficult to meet the request of Hg0 removal. Here, a small amount of Cl was doped into the crystal lattice of Cu2O nanocrystals (Cl-Cu2O), presenting excellent Hg0 removal efficiency in chlorine-free coal combustion flue gas. SEM, XRD, BET, and XPS characterizations revealed well crystal morphology and structure of Cl-Cu2O catalyst. Besides, Cl-Cu2O had smaller sizes and higher BET surface area compared with Cu2O. Hg0 removal behaviors were studied using a lab-scale fixed-bed reactor. After doping Cl, Hg0 removal efficiency was improved obviously and could reach nearly 100% above 150 â„ƒ, indicating chlorine incorporated into the catalyst lattice had a better role for Hg0 removal. Besides, gas composition effect on Hg0 removal was analyzed. Cl-Cu2O had high sulfur resistance capacity, and Hg0 removal efficiency can still reach above 90% even at 2000 ppm SO2. O2 played a critical role in the Hg0 removal reaction. Furthermore, a plausible mechanism for Hg0 removal was analyzed. Doping Cl into the lattice of Cu2O nanocrystals was beneficial for the activation of molecular oxygen, and generated reactive oxygen species can further activate Cl to participate in the Hg0 removal reaction.

Near-infrared responsive upconversion glass-ceramic@BiOBr heterojunction for enhanced photodegradation performances of norfloxacin.

An efficient luminous and electronic energy transmission BiOBr based near-infrared (NIR) responsive heterojunction photocatalyst was successfully fabricated through growing BiOBr nanosheets on the superficial layer of the SrF2-Bi2O3-B2O3/Yb3+,Tb3+ (SBBF) upconversion glass-ceramic (GC) via a facile in-situ etching GC method (FIEG). A high norfloxacin (NOR) degradation rate of 56% was obtained under 180 min NIR light irradiation for the NIR GC photocatalyst (SBBF/BiOBr-10), and it possesses much enhanced photocatalytic activity compared with that of pure BiOBr under UV-vis-NIR light irradiation. Wherein six intermediate products were identified in the NOR photodegradation process and the possible degradation pathways were proposed. B3+, Yb3+ and Tb3+ ions in GC can be doped into BiOBr layer during the FIEG process. The core-shell structure of the GC@BiOBr heterojunction photocatalyst is in favor of increasing charge transport and reducing the recombination rate of excited carriers, and it efficiently harvests NIR photons to emit UV and visible light upconversion emissions, which can be utilized during the photocatalysis process. The photocatalyst can be facilely regenerated via HBr etching again, moreover, the low-cost and less time requirement promote the possibility of large-scale fabrication of the efficient photocatalysts.

Moxibustion for primary dysmenorrhea: A protocol for evidence-based clinical practice guideline.

BACKGROUND: Primary dysmenorrhea (PD) is a common gynecological disease characterized by lower abdominal pain. Moxibustion as a traditional Chinese treatment, can effectively treat PD with few adverse reactions. Nowadays, there is still no standard guideline for moxibustion treatment of PD, so related clinical practice guidelines need to be developed. METHODS: This guideline will be developed in line with the latest guideline definition from Institute of Medicine, and that applies the GRADE system as well as the World Health Organization handbook to appraise the quality of evidence and develop recommendations. We will set up a Guideline working group, put forward the corresponding problems based on the principle of Population, Intervention, Comparison, Outcomes (PICO), and complete the literature retrieval. After achieving consensus through evidence syntheses and 2 to 3 rounds of Delphi process, we will also consider patients values and preferences and implement peer review in the guideline. RESULT: We will put forward evidence-based best practice recommendations and moxibustion standard to improve the symptoms caused by primary dysmenorrhea in a more efficient way. At present, the research is still in progress, and there is no result to report. CONCLUSIONS: This guideline will be helpful to clinical acupuncturists and other professionals to further improve clinical efficacy in treating PD with moxibustion. Moreover, we will also constantly update and evaluate the evidence to both support recommendations and identify gap areas for future research. SYSTEMATIC REVIEW REGISTRATIONS: registration number: IPGRP-2020CN021.

The effectiveness of Du moxibustion for ankylosing spondylitis: A protocol for systematic review and meta-analysis of randomized clinical trials.

BACKGROUND: Ankylosing spondylitis (AS) is a common progressive autoimmune inflammatory disease. Du moxibustion can effectively treat AS with few adverse reactions. The aim of this protocol is to systematically investigate the effectiveness and safety for management of AS with Du moxibustion. METHODS: Seven relevant databases, namely, PubMed, Cochrane Library, Embase, Chinese Biomedical Literatures Database (CBM), China National Knowledge Infrastructure (CNKI), WangFang Database (WF), Chinese Scientific Journal Database (VIP) will be searched from their inception until May 1st, 2020. All clinical randomized controlled trials containing eligible interventions(s) and outcome(s) will be included, regardless of blinding or publication types. Two reviewers will independently retrieval databases, extract data, and then assess the quality of studies. Data synthesis will be conducted by RevMan 5.3 software. We regard the effective rate, Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Visual Analogue Scale (VAS) as the primary outcomes, and the secondary outcomes contain C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), finger-to-floor distance (FFD), occiput to wall distance (OWD), and side effects. The result about the curative effect and safety of Du moxibustion for AS will be presented as risk ratio for dichotomous data and mean differences with a 95% confidence interval for continuous data. RESULTS: The finding will be presented in a journal or related conferences. CONCLUSIONS: This study expects to provide high-quality, evidence-based recommendations on further treatment for clinical guidance. PROSPERO REGISTRATION NUMBER: CRD42020158727.

Moxibustion for treating chronic pelvic inflammatory disease: A protocol for systematic review and meta-analysis.

BACKGROUND: Chronic pelvic inflammatory disease (CPID) is a difficult-to-treat gynaecological disorder, which has complex etiologies, among married women. In recent years, moxibustion has gradually shown its clinical advantages and been more and more widely used In China. The protocol is try to synthesize and assess the effectiveness and safety of moxibustion for patients with CPID. METHODS: Seven databases as following: PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, WangFang Database, Chinese Scientific Journal Database, Chinese Biomedical Literatures Database will be searched from their inception to May 2020. No restrictions about language and status. Study selection, data collection, and quality assessment will be respectively conducted by 2 researchers. Based on the heterogeneity test results, the fixed-effects or random-effects model will be selected to synthesize data. The effective rate, Pelvic inflammatory mass diameter and Pelvic fluid depth will be the primary outcomes. Patient reported outcome scale, visual analog scale, C-reactive protein, transforming growth factor ß1 =  transforming growth factor ß, incidence of any adverse events will be the secondary outcomes. Revman 5.4 software will be implemented for data synthesis. Dichotomous data will be represented by risk ratio for efficacy and safety of CPID treated with moxibustion, while continuous data will be represented by mean difference with a 95% confidence interval. RESULTS: The results of this study will be published in a peer-reviewed journal. This study will provide a comprehensive review of the available evidence for the treatment of moxibustion with CPID. CONCLUSIONS: This study expects to provide high-quality, evidence-based recommendations on further treatment for clinical guidance of CPID. TRIAL REGISTRATION NUMBER: CRD42020158744 in PROSPERO 2020.

Removal and recovery of chloride ions in concentrated leachate by Bi(III) containing oxides quantum dots/two-dimensional flakes.

The high concentration of chloride (Cl-) ions in leachate often has negative effects in their harmless treatments, and the common treatments containing the ion exchange method consume excessive antichlors due to their large particle sizes and unfavorable morphologies. Herein, the antichlors of the Bi(III) containing oxides with quantum dots (QDs) or two-dimensional (2D) structures are first explored for the removal and recovery of Cl- ions in concentrated leachate. By using the QDs/2D flakes constructed antichlors of Bi2O3 and the magnetite Bi-Ti composite, the maximum Cl- removal rates of 61.8% and 66.1% are respectively achieved under the optimum conditions. The higher removal efficiency of the magnetite Bi-Ti composite is contributed by its less stable crystal phases of Bi25FeO40/Bi12TiO20, which can proceed more deeply in the removal of Cl- ions compared with that of Bi2O3. The recovered terminal magnetite Bi-Ti precipitate with Bi2O3/BiOCl heterostructure exhibits excellent photocatalytic activity in the degradation of the dechlorinated leachate, where a total organic carbon removal rate of 87.2% is achieved under UV-vis-near-infrared irradiation. Therefore, the selection of Bi(III) containing oxides opens a promising and high-value method for the removal and recovery of Cl- ions in leachate and other waste waters.

Acupuncture for post-stroke insomnia: A protocol for systematic review and meta-analysis.

BACKGROUND: Post-stroke insomnia (PSI) is a significant complication of stroke, which often affects patients in various aspects. Acupuncture has fewer side effect and is increasingly used to treat PSI. The purpose of this study is to summarize the efficacy and safety of acupuncture for PSI. METHODS: We will perform a comprehensive electronic searching, including PubMed, Embase, Cochrane Library, WangFang Database, China National Knowledge Infrastructure, Chinese Scientific Journal Database, Chinese Biomedical Literature Database, from inception to July 2020. We will also manually retrieve references, and contact lead authors. Randomized clinical trials (RCTs) of acupuncture for PSI will be included, regardless of whether blind method and allocation concealment are used. The outcomes of interest include: Pittsburgh Sleep Quality Index (PSQI), Insomnia Severity Index (ISI), efficacy standards of Chinese medicine, relapse rate after follow-up, adverse events, quality of life. To assess the risk of bias, we will use the Cochrane risk assessment tool. RevMan 5.3 software will be used to conduct data synthesis. The evidence quality of each outcome will be appraised according to Grades of Recommendation, Assessment, Development, and Evaluation (GRADE). RESULTS: The results will be published in a peer-reviewed journal. CONCLUSION: This study will provide a high-quality evidence to evaluate the efficacy and adverse reactions of acupuncture for PSI. PROSPERO REGISTRATION NUMBER: CRD42020157865.

The effectiveness of acupuncture and moxibustion for treating tenosynovitis: A systematic review and meta-analysis protocol.

BACKGROUND: De Quervain's tenosynovitis is an overuse disease that involves a thickening of the abductor pollicis longus and extensor pollicis brevis tendons. Evidence shows that acupuncture and moxibustion (AM) could remarkably relieve the pain of De Quervain's tenosynovitis patients. The aim of this protocol is to determine the efficacy and safety of AM for treating De Quervain's tenosynovitis. METHODS: Several online databases including PubMed, Cochrane Library, Embase, Chinese Biomedical Literatures Database, China National Knowledge Infrastructure, WangFang Database, Chinese Scientific Journal Database will be searched from their establishment to July 1, 2020. We will include all randomized controlled trials using AM as the method for treating De Quervain's tenosynovitis, regardless of blinding or publication types. The selection of studies, data extraction and the assessment of the studies quality will be conducted by 2 reviewers separately. When there is sufficient available data for meta-analysis, we will use the RevMan V.5.3 statistical software for data synthesis. The total effective rate, range of motion of wrist ulnar deviation will be the primary outcomes, and the secondary outcomes contain Visual Analog Scale, Coney Wrist Score and side effects. We will express the result by using Risk ratio for dichotomous data and mean differences with a 95% confidence interval for continuous data. RESULTS: The results of this study be presented in corresponding journal or conferences. CONCLUSIONS: This study is designed to provide sufficient evidence to assess the exact effectiveness of AM on De Quervain's tenosynovitis. PROSPERO REGISTRATION NUMBER: CRD42020158764.

Acupuncture for mammary gland hyperplasia: A Bayesian network meta-analysis protocol.

BACKGROUND: Multiple randomized controlled trials have shown that acupuncture (ACU) work well in the treating mammary gland hyperplasia, which has been widely used in hospitals of China. Although the choices of ACU treatments varies in practice, most are based on experience or preference. Therefore, we outline a plan to assess and rank the efficacy of the various ACU methods to formulate a prioritized regimen for mammary gland hyperplasia in ACU therapy. METHODS: We will make a comprehensive retrieval in 7 databases as following: PubMed, Embase, Cochrane Library, China BioMedical Literature, China National Knowledge Infrastructure, Chinese Scientific Journals Database, and Wanfang database. The time is limited from the construction of the library to June 2020. We will evaluate the quality and the evidence of the included randomized controlled trials by the risk of bias tool and grading of recommendations assessment, development and evaluation, respectively. Bayesian network meta-analysis will be conducted using Stata16.0 and WinBUGS V.1.4.3. RESULTS: The results of this study will be published in a peer-reviewed journal. CONCLUSIONS: Our study is expected to provide high-quality, evidence-based recommendations on further treatment of MGH for clinicians. REGISTRATION: PROSPERO (registration number CRD42020158743).

Acupuncture and related techniques for restless legs syndrome: A protocol for systematic review and meta-analysis.

BACKGROUND: Restless legs syndrome (RLS) is a common sensory disorder of the nervous system, which often affects the sleep quality of patients. Acupuncture and related techniques are increasingly used to treat neurological diseases, but their efficacy and safety for RLS are yet to be established. The purpose of this study is to summarize the effectiveness and safety of acupuncture and related techniques for RLS. METHODS: We will conduct a comprehensive data retrieval, and the electronic databases will include PubMed, Embase, Cochrane Library, WangFang Database, China National Knowledge Infrastructure, Chinese Scientific Journal Database, Chinese Biomedical Literature Database, from establishment to October 2020. We will also manually search unpublished studies and references, and contact lead authors. Randomized clinical trials (RCTs) of acupuncture and related techniques for RLS will be included. The outcomes of interest include: The total effective rate and International Restless Leg Syndrome rating scale (IRLS), Pittsburgh Sleep Quality Index (PSQI), Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD), adverse events, quality of life. To assess the methodological quality, we will use the Cochrane risk assessment tool. RevMan 5.3.5 software will be used to conduct data synthesis. The evidence quality of each outcome will be appraised according to Grades of Recommendation, Assessment, Development, and Evaluation (GRADE). RESULTS: The results will be published in a peer-reviewed journal. CONCLUSION: This study will provide a high-quality evidence to evaluate the efficacy and adverse reactions of acupuncture and related techniques for RLS. PROSPERO REGISTRATION NUMBER: CRD42020157957.

Synthesis of an efficient lanthanide doped glass-ceramic based near-infrared photocatalyst by a completely waterless solid-state reaction method.

A novel efficient near-infrared photocatalyst of oxyfluoride glass-ceramic (Er3+/Yb3+-CaO-Al2O3-SiO2-CaF2)/TiO2 was synthesized by a simple solid-state reaction method, with optically active center (Er3+/Yb3+) doped CaF2 nanocrystals in glass-ceramic micro powders and nanosized anatase TiO2 as the superficial coating. This near-infrared photocatalyst preparation method has a high production efficiency with no wastewater generated.