RESUMEN
OBJECTIVES: The frequency and intensity of extreme heat events are increasing in New York State (NYS) and have been linked with increased heat-related morbidity and mortality. But these effects are not uniform across the state and can vary across large regions due to regional sociodemographic and environmental factors which impact an individual's response or adaptive capacity to heat and in turn contribute to vulnerability among certain populations. We developed a heat vulnerability index (HVI) to identify heat-vulnerable populations and regions in NYS. STUDY DESIGN: Census tract level environmental and sociodemographic heat-vulnerability variables were used to develop the HVI to identify heat-vulnerable populations and areas. METHODS: Variables were identified from a comprehensive literature review and climate-health research in NYS. We obtained data from 2010 US Census Bureau and 2011 National Land Cover Database. We used principal component analysis to reduce correlated variables to fewer uncorrelated components, and then calculated the cumulative HVI for each census tract by summing up the scores across the components. The HVI was then mapped across NYS (excluding New York City) to display spatial vulnerability. The prevalence rates of heat stress were compared across HVI score categories. RESULTS: Thirteen variables were reduced to four meaningful components representing 1) social/language vulnerability; 2) socioeconomic vulnerability; 3) environmental/urban vulnerability; and 4) elderly/ social isolation. Vulnerability to heat varied spatially in NYS with the HVI showing that metropolitan areas were most vulnerable, with language barriers and socioeconomic disadvantage contributing to the most vulnerability. Reliability of the HVI was supported by preliminary results where higher rates of heat stress were collocated in the regions with the highest HVI. CONCLUSIONS: The NYS HVI showed spatial variability in heat vulnerability across the state. Mapping the HVI allows quick identification of regions in NYS that could benefit from targeted interventions. The HVI will be used as a planning tool to help allocate appropriate adaptation measures like cooling centers and issue heat alerts to mitigate effects of heat in vulnerable areas.
Asunto(s)
Trastornos de Estrés por Calor/epidemiología , Calor/efectos adversos , Encuestas y Cuestionarios , Poblaciones Vulnerables , Humanos , New York/epidemiología , Reproducibilidad de los Resultados , Factores de Riesgo , Factores SocioeconómicosRESUMEN
This study assessed the relationship between teacher-reported symptoms and classroom carbon dioxide (CO2 ) concentrations. Previous studies have suggested that poor indoor ventilation can result in higher levels of indoor pollutants, which may affect student and teacher health. Ten schools (9 elementary, 1 combined middle/high school) in eight New York State school districts were visited over a 4-month period in 2010. Carbon dioxide concentrations were measured in classrooms over 48-h, and teachers completed surveys assessing demographic information and self-reported symptoms experienced during the current school year. Data from 64 classrooms (ranging from 1 to 9 per school) were linked with 68 teacher surveys (for four classrooms, two surveys were returned). Overall, approximately 20% of the measured classroom CO2 concentrations were above 1000 parts per million (ppm), ranging from 352 to 1591 ppm. In multivariate analyses, the odds of reporting neuro-physiologic (i.e., headache, fatigue, difficulty concentrating) symptoms among teachers significantly increased (OR = 1.30, 95% CI = 1.02-1.64) for every 100 ppm increase in maximum classroom CO2 concentrations and were non-significantly increased in classrooms with above-median proportions of CO2 concentrations greater than 1000 ppm (OR = 2.26, 95% CI = 0.72-7.12).
Asunto(s)
Contaminación del Aire Interior/análisis , Dióxido de Carbono/análisis , Enfermedades Profesionales/epidemiología , Exposición Profesional/análisis , Instituciones Académicas , Adulto , Trastornos del Conocimiento/epidemiología , Fatiga/epidemiología , Femenino , Cefalea/epidemiología , Humanos , Masculino , New York/epidemiología , Encuestas y Cuestionarios , Enseñanza , VentilaciónRESUMEN
UNLABELLED: Asthma is a leading chronic disease among children and places a significant burden on public health. Exposure to indoor mold has been associated with asthma symptoms. However, many mold assessments have relied on visual or other identification of damp conditions and mold presence, thus have not examined associations with specific fungal genera. The objective of this case-control study was to examine the relationship between airborne mold concentrations and asthma status among children and to identify the contribution from specific mold genera in air. Participants completed a questionnaire of home environmental conditions and underwent indoor air sampling in the home, from which viable and total-count fungal spores were quantified. The most prevalent fungi in the homes were the allergenic molds Cladosporium (98% and 87% of homes from viable and total count samples, respectively) and Penicillium (91% and 73%). There were no significant differences in mean fungal concentrations between the homes of cases and controls, although the observed rate of exposure to several molds was higher among the cases. Among children who lacked a family history of asthma, cases had significantly higher exposures to viable Aspergillus. Measured humidity levels in the home corresponded with some self-reported indicators of mold and dampness. PRACTICAL IMPLICATIONS: The results of this study support existing literature that indoor fungal exposures play a role in current asthma status and that some qualitative assessments of mold exposure correspond to fungi present in indoor air.
Asunto(s)
Contaminación del Aire Interior/análisis , Asma/diagnóstico , Hongos/aislamiento & purificación , Adolescente , Alérgenos/aislamiento & purificación , Asma/epidemiología , Asma/etiología , Estudios de Casos y Controles , Niño , Preescolar , Cladosporium/aislamiento & purificación , Vivienda , Humanos , Análisis Multivariante , New York/epidemiología , Penicillium/aislamiento & purificación , Instituciones AcadémicasRESUMEN
We examined the relationship between lead exposure and fertility among men in a retrospective cohort study. Fertility (1981-1992) of lead-exposed workers was determined from birth certificate information and was compared with that of nonexposed workers. The exposed group consisted of 4256 reproductive-age male workers reported to the New York State Heavy Metals Registry. The comparison group consisted of a random sample of male bus drivers licensed in the state of New York; these men were frequency-matched by age and residence to the men who were exposed to lead. The actual number of births among lead workers was lower than the expected number of births for that group (standardized fertility ratio [SFR] = 0.88; 95% confidence interval [CI] = 0.81-0.95), especially among those who had elevated blood lead levels for longer than 5 years (SFR = 0.43; 95% confidence interval [CI]: = 0.31, 0.59). Even after adjusting for age, race, education, and residence, workers with > 5 years of exposure had reduced likelihood of fathering a child than those with a shorter period of exposure (relative risk, 0.38; 95% CI: 0.23, 0.61). Our study indicates that men with a long duration of lead exposure might have reduced fertility.
Asunto(s)
Infertilidad Masculina/inducido químicamente , Infertilidad Masculina/epidemiología , Plomo/efectos adversos , Exposición Profesional/efectos adversos , Adulto , Certificado de Nacimiento , Tasa de Natalidad , Estudios de Cohortes , Humanos , Plomo/sangre , Modelos Logísticos , Masculino , Persona de Mediana Edad , New York/epidemiología , Exposición Profesional/estadística & datos numéricos , Ocupaciones/estadística & datos numéricos , Sistema de Registros , Estudios Retrospectivos , Factores de TiempoRESUMEN
A study was conducted to determine concentrations of polychlorinated biphenyls (PCBs) in local fish and to establish patterns of fish consumption of nursing Mohawk women residing near three industrial hazardous waste sites. From 1986 to 1992, 97 Mohawk women were interviewed within one month postpartum. A comparison group consisted of 154 nursing Caucasians. Samples of 348 local fish were analyzed for PCBs. The results indicated that fish in the Mohawk area, especially those collected offshore from the waste sites, had been contaminated with PCBs. The dietary data showed a greater past prevalence of local fish consumption among Mohawk mothers, with an overall annual mean of 23.5 local fish meals more than one year before the pregnancy compared with 14.1 for the control women (p < 0.001). The prevalence of consumption by the Mohawks, however, declined over time, resulting in overall mean rates of 9.2 local fish meals one year or less before pregnancy, and 3.9 meals per year during pregnancy (p < 0.001 for linear trend). Compared to the Mohawks, significantly fewer control women stopped eating local fish, and their rates declined less sharply. A secular trend was also observed in the overall rate of consumption during pregnancy for the Mohawks, with those who gave birth in 1986-1989 having a mean of 10.7 local fish meals per year during pregnancy, compared with means of 3.6 and 0.9 respectively for women who delivered in 1990 and 1991-1992 (p < 0.05 for linear trend). No such trend was apparent for the controls. No background variable was significantly related to the rate of local fish consumption among the Mohawks, but a decrease over time in the rate of local fish consumption was greater among those Mohawks who ate the most local fish initially (r = -0.76, p < 0.001), or who also reduced their alcohol intake during pregnancy (r = 0.35, p < 0.05). Mohawks were also more likely than the controls to trim the fat, remove the skin from, and fry and fish they ate during the past year. These dietary changes may be the result of advisories that have been issued over the past decade recommending against the consumption of local fish by pregnant and nursing Mohawk women. Such changes, if sustained, should reduce their exposure to PCBs and correspondingly the potential for adverse health effects.
Asunto(s)
Lactancia Materna , Peces , Contaminación de Alimentos/análisis , Indígenas Norteamericanos , Bifenilos Policlorados , Contaminantes Químicos del Agua , Adulto , Animales , Conducta Alimentaria , Femenino , Agua Dulce , Residuos Peligrosos , Humanos , New York , Ontario , Proyectos Piloto , Embarazo , QuebecRESUMEN
This study examined the association of contaminated fish consumption and polychlorinated biphenyl (PCB) body burden by comparing the similarity of the congener pattern in yellow perch, caught near the point source of industrial pollution, and in other local fish to the pattern found in the breast milk of Mohawk women from Akwesasne, a Native American community located along the St. Lawrence River in New York, Ontario, and Quebec. The similarity is defined by the weighted Euclidean distance between two congener patterns. Ninety-seven Mohawk mothers participated and provided samples of breast milk. One hundred fifty-four nursing women from the Supplemental Nutrition Program for Women, Infants and Children (WIC) of Warren and Schoharie counties, New York, who gave birth during the same time period, were used as the comparison group. Results revealed that the breast milk of the Mohawk women, who ate the most local fish, had a congener pattern that more closely resembled that of perch caught near the waste site or average sampled fish caught in the Reserve than Mohawk women who ate less fish or the controls. The outcome demonstrates how PCBs may be "fingerprinted" as they migrate offsite from industrial sources and ultimately result in human exposure.
Asunto(s)
Peces , Contaminación de Alimentos , Indígenas Norteamericanos/estadística & datos numéricos , Exposición Materna/estadística & datos numéricos , Leche Humana/química , Bifenilos Policlorados/análisis , Contaminantes Químicos del Agua/análisis , Animales , Estudios de Casos y Controles , Ingestión de Alimentos , Femenino , Humanos , New York/epidemiología , Ontario/epidemiología , EmbarazoRESUMEN
A study was conducted to assess the extent to which the consumption of local fish contaminated with p,p'-dichlorodiphenyl dichloroethylene (p,p'-DDE), mirex, and hexachlorobenzene (HCB) has impacted the concentrations of these compounds in the milk of nursing Mohawk women residing along the St. Lawrence River. From 1986 to 1992, 97 Mohawk women were interviewed, and each donated a one-time sample of at least 50 ml of breast milk. The comparison population consisted of 154 Caucasians from other rural areas in New York State. After adjustment for potential confounders, Mohawk mothers who gave birth from 1986 to 1990 had significantly higher geometric mean p,p'-DDE milk concentrations than did the control group, but no significant differences were observed from 1991 to 1992. In contrast, mirex was significantly elevated among the Mohawks throughout the study period, while HCB showed no difference at any point. Mohawk women with the greatest estimated cumulative lifetime exposure to p,p'-DDE from local fish consumption had a significantly higher geometric mean milk level of that compound relative to control women, but no differences in mirex or HCB concentrations in breast milk by local fish consumption were found. The reduction in breast milk p,p'-DDE concentrations among the Mohawk women from 1986 to 1990 parallels a corresponding decrease in local fish consumption, and may be the result of the advisories that have been issued over the past decade recommending against the consumption of local fish by pregnant and nursing Mohawk women. Elevations in the concentrations of mirex in the breast milk of the Mohawks are consistent with the fact that it is a common contaminant in the region and throughout the Lake Ontario-St. Lawrence River Basin.
Asunto(s)
Diclorodifenil Dicloroetileno/farmacocinética , Contaminación de Alimentos , Fungicidas Industriales/farmacocinética , Hexaclorobenceno/farmacocinética , Insecticidas/farmacocinética , Leche Humana/química , Mírex/farmacocinética , Alimentos Marinos , Adulto , Animales , Diclorodifenil Dicloroetileno/análisis , Dieta , Exposición a Riesgos Ambientales , Femenino , Peces , Fungicidas Industriales/análisis , Hexaclorobenceno/análisis , Humanos , Insecticidas/análisis , Mírex/análisis , New York/epidemiologíaRESUMEN
Those who work on farms continue to have a strikingly high prevalence of hearing loss, despite efforts to promote hearing conservation in agriculture. To develop improved hearing conservation programs, we performed a source apportionment analysis for hearing loss in a large, multiphasic health survey, the New York Farm Family Health and Hazard Survey. We used information from audiometric, otoscopic, and tympanometric examinations; detailed general health and farm exposure interviews; and a second interview that focused on additional potential determinants of hearing loss. Hearing loss on audiometry was significantly associated with increased age, male gender, education through high school or less, lifetime years of hunting with guns, lifetime years of use of a grain dryer, and a history of spraying crops during the previous year. Hearing conservation programs for farmers should thus be directed toward reduction in noise exposure, both from occupational and non-occupational sources. Additional study is needed to evaluate the association seen between crop spraying and hearing loss.
Asunto(s)
Enfermedades de los Trabajadores Agrícolas/etiología , Enfermedades de los Trabajadores Agrícolas/prevención & control , Trastornos de la Audición/etiología , Trastornos de la Audición/prevención & control , Ruido en el Ambiente de Trabajo/efectos adversos , Adulto , Factores de Edad , Enfermedades de los Trabajadores Agrícolas/diagnóstico , Audiometría , Estudios Transversales , Exposición a Riesgos Ambientales/efectos adversos , Femenino , Encuestas Epidemiológicas , Trastornos de la Audición/diagnóstico , Humanos , Masculino , Persona de Mediana Edad , Análisis Multivariante , Exposición Profesional/efectos adversos , Probabilidad , Análisis de Regresión , Factores de Riesgo , Factores Sexuales , Estados Unidos/epidemiologíaRESUMEN
The New York State Farm Family Health and Hazard Surveillance was conducted to assess the health status and safety practices among year-round adult farmers and farm residents in New York State and included a telephone interview survey of 1,727 persons from 552 farms. To determine the extent to which self-reported hearing loss is in agreement with audiometry, a subset of 376 participants who completed a hearing loss interview and pure-tone audiometry was analyzed. Thirty-six percent of the participants had self-reported hearing loss, defined as at least some difficulty hearing in one or both ears. The prevalence of audiometric hearing impairment, defined as a threshold average greater than 25 dB hearing level, was 9% for the binaural low-frequency average (500, 1000, and 2000 Hz), 29% for the binaural mid-frequency average (1000, 2000, 3000, and 4000 Hz), and 47% for the binaural high-frequency average (3000, 4000, 6000, and 8000 Hz). Agreement between self-report and audiometry was highest for the binaural mid-frequency average (kappa statistic 55%, sensitivity 77%, and specificity 82%). Self-reported hearing loss was found to be a moderately good measure of hearing impairment. We conclude that a simple questionnaire focusing on hearing difficulty is a useful and valid tool for conducting epidemiologic studies of farmers. Whenever possible, a substudy using audiometry should be conducted.
Asunto(s)
Enfermedades de los Trabajadores Agrícolas/epidemiología , Trastornos de la Audición/diagnóstico , Trastornos de la Audición/epidemiología , Autoevaluación (Psicología) , Adulto , Anciano , Anciano de 80 o más Años , Audiometría de Tonos Puros , Estudios de Cohortes , Femenino , Humanos , Masculino , Persona de Mediana Edad , Prevalencia , Índice de Severidad de la Enfermedad , Encuestas y CuestionariosRESUMEN
A radiologist in New York reported a high prevalence of pulmonary fibrosis in St. Lawrence and Jefferson counties. The New York State Department of Health responded by conducting a case history study of radiographic abnormalities found in the lung parenchyma and pleura of residents in Lawrence and Jefferson counties, where tremolitic talc has been mined for many years. During a 1-y period, all radiographs from 6 hospitals in the region were reviewed. A B-reader confirmed that 355 of 9,442 patients who were at least 40 y of age (3.8%) had a relevant abnormality; 60% of them reported occupational exposure to asbestiform minerals, and another 15% had a chest condition or injury that could have accounted for the abnormal radiograph. The results should be interpreted cautiously, but there was no evidence of widespread radiographic abnormalities resulting from ambient dust exposure. The data, however, support earlier studies that indicate that talc miners and millers experience excess parenchymal fibrosis and pleural changes. The data also suggest that individuals in the paper industry and construction trades may be at risk.
Asunto(s)
Amianto/efectos adversos , Minería , Exposición Profesional , Fibrosis Pulmonar/epidemiología , Talco , Adulto , Anciano , Anciano de 80 o más Años , Causalidad , Femenino , Indicadores de Salud , Humanos , Masculino , Persona de Mediana Edad , New York/epidemiología , Prevalencia , Fibrosis Pulmonar/diagnóstico por imagen , Fibrosis Pulmonar/etiología , Radiografía , Factores de RiesgoRESUMEN
This nested case-control study examined the association between prevalent asthma and indoor allergen sensitization and/or exposure among children (aged 5-17 years) in Buffalo, New York. The study included a self-administered questionnaire, clinical interviews, skin allergen sensitivity tests and home dust sampling for house dust mites, cat, dog, cockroach and mouse allergens. After adjusting for multiple confounders, asthma cases had higher odds of being sensitized to Der p dust mites (odds ratio [OR]=1.94, 95% confidence interval (CI): 1.13-3.35), cat (OR=1.96, 95% CI: 1.13-3.39), or dog allergens (OR=1.89, 95% CI: 1.10-3.22) than the controls. A significantly positive association between asthma status presence of cat allergen in the child's mattress (ORs: 2.61, 95% CI: 1.09-6.28) was also found. Children with both sensitization and environmental exposure to cat allergens had higher odds of asthma (OR=7.08, 95% CI: 2.12-23.62) than those who were only sensitized to cat allergen (OR=2.31, 95% CI: 1.01-5.32) or had only home exposures (OR=1.47, 95% CI: 0.47-4.65). The association between allergen sensitization and asthma was more consistent than for home exposures. The findings help to confirm the role of allergen sensitization and home exposure in regard to asthma, and suggest that both, individually and jointly, are associated with asthma.
Asunto(s)
Alérgenos/inmunología , Asma/inmunología , Exposición a Riesgos Ambientales , Animales , Estudios de Casos y Controles , Gatos , Niño , Preescolar , Cucarachas/inmunología , Perros , Polvo/inmunología , Humanos , Ratones , New York , Pyroglyphidae/inmunología , Pruebas CutáneasRESUMEN
OBJECTIVE: This study assessed whether residents living near commercial airports have increased rates of hospital admissions due to respiratory diseases compared to those living farther away from these airports. METHODS: This cross-sectional study included all residents living within 12 miles from the center of each three airports (Rochester in Rochester, LaGuardia in New York City and MacArthur in Long Island). We obtained hospital admission data collected by the NYS Department of Health for all eligible residents who were admitted for asthma, chronic bronchitis, emphysema, chronic obstructive pulmonary disease and, for children aged 0-4 years, bronchitis and bronchiolitis during 1995-2000. Exposure indicators were distance from the airport (< or =5 miles versus >5 miles) and dominant wind-flow patterns from the airport (>75th percentile versus < or =75th percentile), as well as their combinations. RESULTS: Increased relative risks of hospital admissions for respiratory conditions were found for residents living within 5 miles from the airports (1.47; 95% CI 1.41, 1.52 for Rochester and 1.38; 95% CI 1.37, 1.39 for LaGuardia) compared to those living >5 miles. We did not find positive associations between wind-flow patterns and respiratory hospital admissions among the residents in any airport vicinity. No differences were observed for MacArthur airport using either exposure measure. CONCLUSION: There is the suggestion that residential proximity to some airports may increase hospital admissions for respiratory disorders. However, there are many factors that could influence this association that may differ by airport, which should be measured and studied further.
Asunto(s)
Contaminación del Aire/efectos adversos , Aeronaves , Hospitalización/estadística & datos numéricos , Enfermedades Respiratorias/epidemiología , Humanos , Persona de Mediana Edad , Ciudad de Nueva York/epidemiología , Ruido del Transporte/efectos adversos , Material Particulado/efectos adversosRESUMEN
The effects of domestic wastewater application on the translocation and accumulation of polycyclic aromatic hydrocarbons (PAHs) in soil and crops (rice, lettuce, and barley) were investigated by Wagner's pot experiment. In the soils and crops after domestic wastewater irrigation, high-molecular weight PAHs (5 to 6 ring) were not detected, but low-molecular weight PAHs (3 to 4 ring) were only detected at trace levels.
Asunto(s)
Agricultura , Productos Agrícolas/química , Bifenilos Policlorados/análisis , Aguas del Alcantarillado/análisis , Contaminantes del Suelo/análisis , Suelo/análisis , Eliminación de Residuos Líquidos , Cromatografía de Gases y Espectrometría de Masas , Hordeum/química , Lactuca/química , Oryza/químicaRESUMEN
The development of pulmonary granulomatous lesions during mycobacterial infection is a complex phenomenon, in part caused by responses elicited towards the surface glycolipid trehalose 6,6'-dimycolate (TDM; cord factor). The molecular mechanisms underlying granuloma formation following challenge with TDM are not yet completely understood. The present study defines pathologic differences in acute response to Mycobacterium tuberculosis TDM in C57BL/6 mice and mice lacking the C5a receptor (C5aR-/-). Mice were intravenously injected with TDM prepared in water-in-oil-in-water emulsion and examined for histologic response and changes in proinflammatory cytokines and chemokines in lung tissue. Control C5a receptor-sufficient mice demonstrated a granulomatous response that peaked between days 4 and 7. Increased production of macrophage inflammatory protein-1 alpha (MIP-1alpha), interleukin-1beta (IL-1beta) and CXC chemokine KC (CXCL1) correlated with development of granulomas, along with modest change in tumor necrosis factor-alpha (TNF-alpha). In contrast, the C5aR-/- mice revealed markedly exacerbated inflammatory response. The receptor-deficient mice also demonstrated a lack of coherent granulomatous response, with severe oedema present and instances of lymphocytic cuffing around pulmonary vessels. Lung weight index was increased in the C5aR-/- mice, correlating with increased MIP-1alpha, KC, IL-1beta and TNF-alpha over that identified in the congenic C5aR-sufficient controls. Correlate experiments performed in C5-deficient (B10.D2-H2d H2-T18c Hco/oSnJ) mice revealed similar results, leading to the conclusion that C5 plays a significant role in mediation of chemotactic and activation events that are the basis for maturation of granulomatous responses to TDM.
Asunto(s)
Complemento C5/inmunología , Factores Cordón/inmunología , Granuloma/inmunología , Mycobacterium tuberculosis/inmunología , Receptor de Anafilatoxina C5a/inmunología , Tuberculosis/inmunología , Animales , Quimiocina CCL3 , Quimiocina CCL4 , Quimiocina CXCL1 , Quimiocinas CXC/metabolismo , Histocitoquímica , Péptidos y Proteínas de Señalización Intercelular/metabolismo , Interleucina-1/metabolismo , Proteínas Inflamatorias de Macrófagos/metabolismo , Ratones , Ratones Endogámicos C57BL , Ratones Noqueados , Tuberculosis/patología , Factor de Necrosis Tumoral alfa/metabolismoRESUMEN
This study examined the geographic distribution of asthma hospitalizations in New York State (NYS) and its association with socioeconomic status. Statewide asthma hospitalization data (1987-1993) were merged with 1990 census data by residential zip code. The asthma hospitalization rate increased in NYS from 1987 (2.54 per 1000) through 1993 (2.87 per 1000) and the increase is largely attributable to increases for children 4 years old and younger. The risk factors for asthma admission varied in different areas. However, rates of hospitalization because of asthma were generally higher in the zip codes areas with higher proportions of poverty, unemployment, poorly educated residents, African-Americans, and Hispanics.
Asunto(s)
Asma/terapia , Hospitalización/estadística & datos numéricos , Clase Social , Adolescente , Adulto , Negro o Afroamericano/estadística & datos numéricos , Anciano , Asma/epidemiología , Asma/etnología , Niño , Preescolar , Demografía , Educación , Hispánicos o Latinos/estadística & datos numéricos , Humanos , Lactante , Recién Nacido , Persona de Mediana Edad , Análisis Multivariante , New York , PobrezaRESUMEN
The mortality profile of 9585 male New York State Department of Transportation (NYSDOT) highway maintenance workers was examined by calculating age-era standard mortality ratios (SMRs), using the general male population of upstate New York as a reference group, for the period 1958-1980. The SMR for all workers was 1.14 (95% CI = 1.09, 1.18), with the greatest all-cause mortality among laborers (SMR = 1.23, 95% CI = 1.16, 1.29). The major contributors to this increase among laborers were circulatory system diseases (SMR = 1.18, 95% CI = 1.10, 1.27), diseases of the respiratory system (SMR = 1.34, 95% CI = 1.09, 1.64), digestive system diseases (SMR = 1.57, 95% CI = 1.26, 1.94), genitourinary system diseases (SMR = 1.61, 95% CI = 1.02, 2.41) and accidents, poison, and violence (SMR = 1.44, 95% CI = 1.19, 1.74). Some of the elevated risks observed may be attributed to cigarette smoking and other life-style factors that could not be assessed with the data available. However, the mortality risks for laborers increased with length of employment and latency, suggesting that occupational exposures may be contributing to the elevated risk in this cohort. Further studies should include information on life-style variables and other confounders as well as more detail on specific occupational exposures.
Asunto(s)
Enfermedades Profesionales/mortalidad , Transportes , Adulto , Causas de Muerte , Estudios de Cohortes , Humanos , Masculino , Persona de Mediana Edad , New York/epidemiología , Ocupaciones , Estudios Retrospectivos , Factores de TiempoRESUMEN
To address the increase in the incidence of cutaneous melanoma in upstate New York in recent decades, a case-control study was conducted of the constitutional and environmental risk factors for malignant melanoma of the trunk among white males. Cases were identified from the New York Cancer Registry from 1977 through 1979 (the period of the greatest relative increase in incidence), and controls were selected using random digit dialing methods. A total of 324 cases or their next-of-kin and 415 controls were interviewed regarding physical and sociodemographic characteristics, lifestyle habits, and medical histories. The following variables were statistically significant in the final logistic regression analysis: birthmarks (O.R. = 3.87); sunburn easily (O.R. = 1.83); fair skin tone (O.R. = 1.63); northern European ancestry (O.R. = 1.51); blue eye color (O.R. = 1.46); and participation in water sports (O.R. = 2.02). Interaction terms between constitutional and environmental variables resulted in a significant relationship between the presence of freckles and bathing two or more times per day. Among freckled individuals, those who bathed more than once per day had a sixfold elevation in the risk compared to those who bathed less often. In comparison, the odds ratio for frequent bathing among men without freckles was only 1.24. The data suggest the following hypothesis for further study: the possibility that frequent bathing may be deleterious, especially among freckled individuals or those with pigmented nevi.
Asunto(s)
Melanoma/epidemiología , Neoplasias Cutáneas/epidemiología , Estudios de Casos y Controles , Humanos , Masculino , Melanoma/etiología , New York/epidemiología , Análisis de Regresión , Factores de Riesgo , Neoplasias Cutáneas/etiologíaRESUMEN
A study was conducted to determine the relation between the consumption of contaminated local fish and concentrations of total polychlorinated biphenyls (PCBs) and 68 PCB congeners in the milk of nursing Mohawk women residing near three hazardous waste sites. From 1986 to 1992, 97 Mohawk women were interviewed and donated at least 50 ml of breast milk. The comparison population consisted of 154 Caucasians. After adjustment for potential confounders, Mohawk mothers who gave birth in 1986-1989 had a geometric mean milk total PCB concentration of 0.602 ppm (fat basis) compared with 0.375 ppm for the control group (p = 0.009). These Mohawk women also had significantly higher geometric mean concentrations of nine congeners. Beginning in 1990, however, there were no significant differences between the Mohawk women and the comparison group. Estimated cumulative lifetime exposure from local fish consumption was significantly related to milk total PCB and to three congeners only among those Mohawks who gave birth from 1986 to 1989. The reduction in breast milk PCB concentrations parallels a corresponding decrease in local fish consumption and may be the result of the advisories that have been issued over the past decade recommending against the consumption of local fish by pregnant and nursing Mohawk women.
Asunto(s)
Peces , Contaminación de Alimentos , Indígenas Norteamericanos , Leche Humana/química , Bifenilos Policlorados/análisis , Adulto , Animales , Estudios de Casos y Controles , Factores de Confusión Epidemiológicos , Dieta , Femenino , Residuos Peligrosos , Humanos , Modelos Lineales , Exposición Materna , New York , EmbarazoRESUMEN
The relation between paternal occupational lead exposure and low birth weight/prematurity was examined in a retrospective cohort study. Birth weight and gestational age (1981-1992), obtained from New York State birth certificates, were compared between lead-exposed and nonexposed workers. The exposed group (n = 4,256) consisted of births to male workers of reproductive age reported to the New York State Heavy Metals Registry. The control group (n = 2,318) consisted of the offspring of a random sample of male bus drivers, frequency matched by age and residence. There were no statistically significant differences in birth weight or gestational age between the exposed and the control groups. However, workers who had elevated blood lead levels for more than 5 years had a higher risk of fathering a child with low birth weight (risk ratio = 3.85, 95% confidence interval 1.5-9.88) or prematurity (risk ratio = 2.45, 95% confidence interval 1.03-5.84) than did controls after adjustment for paternal age, low maternal education, race, residence, gravidity, maternal spontaneous abortion history, perinatal complications, adequacy of prenatal care, and infant gender. The risks of low birth weight and prematurity increased with the duration of exposure to lead. Our results were limited by the inability to control for some potential confounders, such as pregravid underweight and maternal nutrition status.
Asunto(s)
Recién Nacido de Bajo Peso , Recien Nacido Prematuro , Plomo/efectos adversos , Metalurgia , Exposición Profesional/efectos adversos , Exposición Paterna/efectos adversos , Adulto , Puntaje de Apgar , Estudios de Cohortes , Escolaridad , Femenino , Humanos , Recién Nacido , Plomo/sangre , Masculino , New York , Paridad , Sistema de Registros , Estudios Retrospectivos , Factores de RiesgoRESUMEN
OBJECTIVES: This study tests the hypothesis that fluoride exposure in a nonoccupational setting is a risk factor for childhood osteosarcoma. METHODS: A population-based case-control study was conducted among residents of New York State, excluding New York City. Case subjects (n = 130) were diagnosed with osteosarcoma between 1978 and 1988, at age 24 years or younger. Control subjects were matched to case subjects on year of birth and sex. Exposure information was obtained by a telephone interview with the subject, parent, or both. RESULTS: Based on the parents' responses, total lifetime fluoride exposure was not significantly associated with osteosarcoma among all subjects combined or among females. However, a significant protective trend was observed among males. Protective trends were observed for fluoridated toothpaste, fluoride tablets, and dental fluoride treatments among all subjects and among males. Based on the subjects' responses, no significant associations between fluoride exposure and osteosarcoma were observed. CONCLUSIONS: Fluoride exposure does not increase the risk of osteosarcoma and may be protective in males. The protective effect may not be directly due to fluoride exposure but to other factors associated with good dental hygiene. There is also biologic plausibility for a protective effect.