RESUMEN
A 5-year-old Korean boy developed multiple subcutaneous, nontuberculous granulomas and died with meningoencephalitis. Autopsy disclosed amebic granulomas in subcutaneous tissue, the left adrenal gland, and the pancreas, with more acute inflammatory lesions in the liver, kidney, and brain. The causative organism is believed to be an Acanthamoeba sp.
Asunto(s)
Amebiasis/complicaciones , Meningoencefalitis/etiología , Glándulas Suprarrenales/patología , Amebiasis/diagnóstico , Amebiasis/patología , Encéfalo/patología , Preescolar , Granuloma/etiología , Humanos , Corea (Geográfico) , Masculino , Meningoencefalitis/diagnóstico , Meningoencefalitis/patología , Piel/patologíaAsunto(s)
Agammaglobulinemia/tratamiento farmacológico , gammaglobulinas/efectos adversos , gammaglobulinas/uso terapéutico , Adulto , Agammaglobulinemia/inmunología , Proteínas Sanguíneas , Hipersensibilidad a las Drogas/etiología , Humanos , Inmunoquímica , Inyecciones Intravenosas , Masculino , Pepsina ARESUMEN
More than 300 patients with neoplastic disease (most with lymphoma or leukemia) were given one or more BCG vaccinations. In the great majority of cases, these were well tolerated. The complications we observed were of three types: (A) persistent BCG infection that could disseminate widely, (B) activation of old, dormant acid-fast infection, and (C) hypersensitivity reactions. The latter were related to the frequency of administration and dose of organisms. It is important to recognize that BCG organisms may not be completely destroyed by patients with impaired immunologic defenses, and that their inoculation may create a source of disseminated acid-fast infection at a later time. In our limited experience, treatment with isoniazid for 2 to 3 months has resulted in cure of BCG infection. Hypersensitivity reactions may constitute a more serious problem than such infections.