[Changes of coefficients of sleep onset, sleep maintenance and awakenings in most common psychiatric disorders in inpatients]. / Charakterystyka przebiegu snu nocnego w niektórych zespolach psychopatologicznych na podstawie wskazników zasypiania, utrzymywania snu i przebudzenia.

INTRODUCTION: The study's purpose was to find differences of selected psychopathological syndromes according to characteristic disturbances of sleep which are present in them. METHODS: Among 194 patients (mean age: 42.27 +/- 14.15) 108 were women (mean age: 42.97 +/- 14.13) and 86 were men (mean age: 41.38 +/- 14.22). Psychiatric examination and sleep disturbance evaluation was done with the use of our own questionnaire: Multidimensional System for Evaluation of Sleep Disorders (MSESD) were performed the third day after admission to a psychiatric ward. Sleep was analysed according to coefficients which described falling asleep, sleep maintenance and awakenings. These coefficients were created according to parameters obtained from MSESD. RESULTS: Coefficients obtained from the "schizophrenic disorders" and "personality disorders" groups did not differ significantly from the average coefficients for all the patients. The common feature among other groups of patients was the elevation of the coefficient of falling asleep especially for the "organic" and "depressive" disorders groups. The most pronounced elevation of the falling asleep coefficient was detected in the "depression without somatic features" group, however this elevation was also clearly seen in the "reactive disorders" group. In the latter group all other coefficients were also significantly elevated. CONCLUSIONS: Constructed coefficients of sleep disturbances may be useful for diagnosing and differentiating the most often psychiatric disorders in inpatients.

[Prognostic value of pharmaco-EEG in depression treated with fluvoxamine]. / Analiza czynnosci bioelektrycznej mózgu u pacjentów leczonych fluwoksamina.

14 patients (age 42.1 +/- 15.5; 12 women, 2 men) with a depressive episode (moderate, mild; ICD-10) were treated with fluvoxamine (150 mg). After 4 weeks two groups with different responses to the drug emerged (10 responders: improvement in Beck Inventory of Depression 13.6 +/- 2.9 and 4 nonresponders: 2.0 +/- 2.4). FFT analysis of their EEG (taken before and after the treatment) showed some relative power differences in most bands of frequencies between groups, mostly marked for à (7-14 Hz) and smaller for the others. Alpha activity was relatively low after treatment in nonresponders and slightly higher in responders. However, none of these results had statistical value.

[Clinical efficacy of citalopram in patients with obsessive-compulsive disorder]. / Skutecznosc citalopramu w leczeniu zaburzen obsesyjno-kompulsyjnych.

16 patients (9 female, 7 male; mean age 32.69 +/- 10.30) with coexisting obsessive-compulsive disorder (OCD) and depression were treated for 6 weeks with citalopram (10-60 mg; mean dosage after 6 weeks--25.71 +/- 12.83 mg). Their mental state was evaluated in the 7th, 14th, 28th and 42nd of treatment by the use of psychiatric examination and self-assessment clinical scales. After 6 weeks of treatment 5 patients were in full remission, 7 in partial remission (totally 75% of patients were responders) and 4 still suffered from OCD or depressive symptoms. In the 1st week of treatment 5 patients complained on temporary aggravation of symptoms but it turned out to have no prognostic value. It is recommended to find early signs of final clinical response.

[Prognostic value of pharmaco-EEG in depression treated with moclobemide]. / Analiza czynnosci bioelektrycznej mózgu u pacjentów leczonych moklobemidem.

Ten women (age 41.90 +/- 5.67) with depressive episode (moderate, mild; ICD-10) were treated with moclobemide (450 mg). After 4 weeks two groups (each consists of 5 patients) with different response to the drug emerged (responders: improvement in Beck Inventory of Depression 13.6 +/- 2.9 and nonresponders: 2.0 +/- 2.4). FFT analysis of their EEG (taken before and after 4 weeks of treatment) showed some relative power differences in most bands of frequencies between groups, mostly marked for á (7-14 Hz), smaller for ä and â, but no differences for è were found. Alfa activity was relatively low after treatment in nonresponders and slightly higher in responders. However any of these results had statistical value.