RESUMEN
Klotho, a gene found on chromosome 13q12, is involved in a variety of processes and signaling pathways in the human body related to vitamin D metabolism; cardiovascular, renal, musculoskeletal, and skin diseases; and cancer biology. However, more importantly, it has been linked to beneficial effects related to anti-aging. The levels of soluble Klotho in the blood have been found to decline with age, increasing the risk of age-related diseases. When the Klotho gene was silenced or defective, it caused a shorter lifespan. However, when the gene was overexpressed, it resulted in a longer lifespan. Klotho has positive benefits on the neurological system by causing a higher representation of useful longevity genes, preventing further neuronal damage, and offering neuroprotection. Thus, it has the potential to become a new treatment for many age-related diseases that cause dementia, including multiple sclerosis, Alzheimer's disease, and Parkinson's disease. In this review, we discuss the mechanisms of Klotho's benefits and roles on various organ systems, specifically on nervous system disorders that lead to dementia.
RESUMEN
PURPOSE: The objective of this analysis was to find an association between employment status, psychological distress, and alcohol consumption. METHODS: Data from the 2020 Health Information National Trends Survey (HINTS) data was used. Patient health questionnaire-4 (PHQ-4) data and an average number of drinks per week were used to assess psychological distress and drinking status. RESULTS: Out of the 3865 people who answered the survey in the year 2020, 1890 (59.11%) were employed in one or multiple jobs during the time of the survey. The sample included 1561 men and 2204 women with an average age of 48.4 years. More than half (58.7%) of them were Non-Hispanic White followed by Hispanic and Non-Hispanic Black at 15.73% and 10.32%, respectively. Bivariate analysis showed a significant association between employment, psychological distress (p value=0.032), and alcohol drinking (p value=0.002); 60.59% of participants reporting severe distress (PHQ-4 score of 9-12) were unemployed. Alternatively, 73.1% of the employed respondents reported no stress (PHQ-4 score of 0-2). While more than half (75.97%) of those who were unemployed consumed only 1-2 drinks per week on an average, 7.27% consumed >13 drinks per week on an average. After adjusting for covariates, the regression analysis showed a highly significant association (p value< 0.001) between unemployment and psychological distress (OR=1.55; 95% CI 1.03, 2.31), and alcohol consumption (OR=0.67; 95% CI 0.48, 0.92). CONCLUSION: Unemployment is associated with outcomes like psychological distress and alcohol consumption. However, being employed was found to be more strongly associated with alcohol drinking. We do not know if the coronavirus disease 2019 (COVID-19) pandemic was a risk factor for the given outcomes.