[An experimental study of the mechanism of the combined action on the body of ionizing radiation, pesticides, nitrates and lead and cadmium salts]. / Eksperymental'ne vyvchennia mekhanizmu kombinovanoï diï na orhanizm ionizuiuchoho vyprominiuvannia, pestytsydiv, nitrativ, solei svintsiu i kadmiiu.

The studies made showed that repeated combined action of chemical factors (pesticides of different chemical groups, Cd and Pb salts, nitrates) in the doses studied resulted in an increase of the lipid peroxidation (LPO) in tissues, accumulation of its end products in biosubstrates, and activation of catalase and peroxidase oxidoreductases in blood of test animals. Combined action of chemical factors and gamma radiation was found out to make for increasing in lipid peroxidation and involving of ceruloplasmin in the LPO inhibition. Depletion of the antioxidant system in repeated irradiations against the background of chemical loading was accompanied by accumulation of the LPO products. We conclude that in the pathogenesis of the revealed changes in associated effects of ionizing radiation, pesticides, nitrates, Plumbum and Cadmium salts, the LPO activation in the presence of the antioxidant system depletion is most important, in view of which fact the specific criteria for the studied factors combined effects on the organism appear to be the activity of the oxidation-reduction enzymes and the level of the-active products, with the chief preventive measures being directed towards increasing of radioresistance of the organism through correction of the antioxidant deficiency.

[The results of the scientific activities of the institutions under the jurisdiction of the Ministry of Public Health]. / Rezul'taty naukovoï diial'nosti pidporiadkovnykh Ministerstvu okhorony zdorov'ia ustanov.

Factographic data are submitted on research potential of the system of health services of Ukraine. An analysis has been performed of the structure of such a potential together with features of its constituents. Attention is drawn to solution of scientific tasks related to basic research problems, the medical science priorities in particular. The analysis of the scientific investigations conducted is accompanied by a demonstration of most weighty results such as those related to working out of health protection-oriented decisions, recommendations on innovative technologies to master new ways for administering treatments and prophylaxis of diseases as well as to theoretical scientific achievements, etc. Weak spots in the organization and conduction of scientific quests in the branch are analyzed, an attempt is made to argue for the causes of this phenomenon. Particular attention is given to deficits in financing of medical science and to low effectiveness of search for extra-budget resources. The authors form ways toward improving the state of medical science in the system of public health services.