Epidemiology of an overlapping and parallel infection of Sexually Transmitted Infections among pregnant women in North-east Ethiopia: Its implication for prevention of mother to child transmission.

BACKGROUND: The burden of parallel and overlapping infections of Sexually Transmitted Infections (STIs), particularly HIV, syphilis, hepatitis B (HBV), and hepatitis C virus (HCV) are disproportionately higher among pregnant women globally, leading to unwanted consequences. These infections pose significant public health challenges as they can be transmitted vertically to the offspring. This study aimed to determine the sero-epidemiological patterns and predictors of STIs (HIV, syphilis, HBV, and HCV) among pregnant women attending antenatal care clinics at ten health facilities in North-eastern Ethiopia. METHODS: An institution-based multi-center cross-sectional study was conducted from May to November 2022 among 422 pregnant women selected using simple random sampling technique. Semi-structured questionnaire was used to collect socio-demographic characteristics and predictor variables of STIs through face-to-face interviews. Venous blood was collected and it was tested for anti-HIV, HBsAg, anti-HCV, and anti-Treponemal antibodies using immunochromatographic test kits. Multinomial logistic regression analysis was used to identify associated factors of STIs. Variables with an adjusted odds ratio (AOR) and a p-value <0.05 were considered statistically significant. RESULTS: The overall prevalence of STIs was 23.9% (95% CI = 20.08-28.25). The prevalence of parallel infections of HIV, hepatitis B, hepatitis C, and syphilis were 6.4%, 9%, 1.7%, and 6.9%, respectively. The overlapping infections for HIV-HBV was 4% but HIV-HCV overlapping infection wasn't found. Increased age, tattooing, multiple sexual partners, exposure to unsafe sex, and RH status were independent factors of HBV. Likewise, increased age, rural residence, illiteracy, and tattooing were independently associated with HCV. Moreover, rural residence and a history of tattooing were independent predictors for the acquisition of HIV, whereas multiple sexual partners and RH status were found to be significant predictors of syphilis infection among pregnant women. CONCLUSION: The magnitude of overlapping and parallel STD infections is still continued to be a problem among pregnant women. Moreover, there were overlapping infections of HBV-HIV. Therefore, continuous screening of pregnant women for HIV, syphilis, hepatitis B, and C infections should be performed, and special attention should be given to pregnant women who have co-infections.

Quantitative assessment and optimization of parallel contact model for flexible paddy straw: a definitive screening and central composite design approach using discrete element method.

To simulate the bending behaviour of paddy straw at varied moisture contents after crop harvesting, we created a flexible paddy straw specimen model based on the Hertz-Mindlin with parallel contact bonding model using the discrete element model (DEM) approach. The research presented in this study aims to investigate a new approach called Definitive Screening Design (DSD) for parameterizing and screening the most significant parameters of the DEM model. This investigation will specifically focus on the three-point bending test as a means of parameterization, and the shear plate test will be used for validation purposes. In addition, the most influential DEM parameters were optimized using another Design of Experiments approach called Central Composite Design. The findings from the DSD indicated that parameters such as bonded disk scale, normal stiffness, and shear stiffness have the highest impact on the bending force, while the coefficient of static friction (Straw-Steel) has the least effect. The three bonding parameters were respectively calibrated with the loading rate (0.42, 0.5, and 0.58 mm s-1) and a good agreement between actual and simulated shear force at moisture content M1-35 ± 3.4%, M2-24 ± 2.2% and M3-17 ± 2.6%. Modelled stem helps simulate the straw with low error and increases the accuracy of the simulation. The validated model, with an average relative error of 5.43, 7.63, and 8.86 per cent, produced reasonable agreement between measured and simulated shear force value and loading rate.

Design and assessment of tractor-driven chopping tilling and mixing machine for in-situ management of paddy straw.

In many Indian regions, paddy wheat is the main crop rotation and facing the problem of straw incorporation for seed bed preparation in short period. The handling of straw in combine harvested paddy fields is a significant issue in the paddy wheat rotation. In order to solve this issue, efforts were carried out to cut paddy straw into small pieces by the newly proposed counter-rotating blades, followed by the simultaneous incorporation of a rotary tiller into the soil. Therefore, a tractor operated chopping cum tilling mixing machine was developed. In the study, three different blades (straw management system (SMS) Serrated, cutter bar and SMS plain) were tested in the terms of torque and required to chop the straw. SMS serrated blade was best suitable for the chopping mechanism as it required minimum cutting torque for the straw bunches. The developed chopping cum tilling mixing machine was tested at three different levels of forward speed (1.77, 2.3, and 3 km h-1), moisture content at three levels (35 ± 3.4, 24 ± 2.2 and 17 ± 2.6%) with fix rotary tiller rotational speed of 810 rev min-1. Optimum operating condition of the machine was obtained at a forward speed of 1.9 km h-1 and a moisture of 24%. At these optimized values, the mixing index (96%), mean weight diameter (7.9 mm), bulk density (1230 g cc-1) and fuel consumption (3 l h-1) were 96%, 7.9 mm, 1230 g cc-1 and 3.0 l h-1 respectively. The developed machine performs three operations i.e., chopping, tilling, and mixing in single pass for effective in-situ straw management.

Prevalence of insomnia and associated factors among postpartum mothers in Southern Ethiopia, a community-based cross-sectional study.

Insomnia has become a global public health concern, particularly among postpartum women. Minimal sleep interruption related to newborn care is normally expected, insomnia, however has negative impact during the postpartum period. Although its causes and contributing factors are poorly understood, it has a wide-ranging impact on the mother and her infant. So far, studies in Ethiopia have focused on the general community, neglecting mothers in the postpartum period. Thus, this study aimed to assess the prevalence of insomnia and the factors associated with it. A community-based cross-sectional study included 451 study participants who were chosen using a simple random sampling technique. A structured, pretested, and interviewer-administered questionnaire was used to collect data. After entering the data into EpiData version 3.1, it was exported to the Statistical Package for Social Sciences version 26 for analysis. Bivariable and multivariable binary logistic regression analyses were carried out. Variables with a P-value of 0.2 in the bivariable analysis were included in the multivariable analyses. Those with a P-value of 0.05 were declared statistically significant in the final model. The current study included 444 mothers in total. Insomnia was prevalent among 23.2% (95% CI: 19.3%, 27.4%) of mothers who had given birth within the previous 12 months. Insomnia was associated with unplanned index pregnancy [AOR = 4.4, 95% CI (2.2, 8.7)], alcohol consumption [AOR = 3.0, 95% CI (1.4, 6.5), low social support [AOR = 9.7, 95% CI (4.4, 21.1)], medium social support [AOR = 2.2, 95% CI (1.1, 4.3)] and depression [AOR = 10.7, 95% CI (5.7, 20.0). A planned index pregnancy, abstaining from alcohol, and recognizing and treating postpartum depression were all advised.