Stereospecific assay and stereospecific disposition of racemic carprofen in rats.

A procedure was developed for the separation and selective quantitative determination of the (S)(+)- and (R)(-)-enantiomers of the racemic anti-inflammatory drug carprofen as their diastereomeric l-(-)-alpha-methylbenzylamides. These derivatives are obtained in equivalent yields by reacint purified 14C-carprofen from biological specimens with l-(-)-alpha-methylbenzylamine via the 1,1'-carbonyldiimidazole intermediate, followed by extraction and differential radiometric quantitation of the TLC-separated diastereomers. In the rat, the (R)(-)-carprofen enantiomer was eliminated from blood and secreted in the bile as the ester glucuronide at a rate approximately twice that of the (S)-(+)-enantiomer, resulting in the accumulation of the pharmacologically more active (S)(+)-enantiomer in the rat blood. Evidence for an additional process favoring the elimination of the (R)(-)-enantiomer in the rat was derived from pharmacokinetic data evaluation.

Evaluating the association of two breastfeeding assessment tools with breastfeeding problems and breastfeeding satisfaction.

This pilot study evaluated how the scores from each of two breastfeeding assessment tools correlated with breastfeeding satisfaction and problems. A convenience sample of 30 first-time breastfeeding mothers participated. Mothers were randomly assigned to use either the LATCH or Infant Breastfeeding Assessment Tool (IBFAT). The Maternal Breastfeeding Evaluation Scale (MBFES) and Potential Early Breastfeeding Problem Tool (PEBPT) were used to evaluate the association of the scores of each assessment tool with breastfeeding satisfaction and breastfeeding problems. As scores on the both the LATCH and IBFAT increased, maternal satisfaction scores tended to increase, but not significantly, and breastfeeding problem scores tended to decrease (r = -0.5, p = 0.06 and r = -0.49, p = 0.06; respectively.