[Effect of etimizol on behavioral responses, brain serotonin concentration and plasma corticosteroid levels]. / Deistvie étimizola na povedencheskie reaktsii, soderzhanie serotonina v mozge i kortikosteroidov v plazme krovi.

The influence of ethymisol on behavioural reactions was studied on 100 albino rats in the "open field" and "passive avoidance" tests. It was shown that a 5 mg/kg dose of this neurotropic drug with synaptic effect, changes behavioural reactions, lowers the general emotional stress and emotional memory of the electro-cutaneous stimulation. Simultaneously the level of corticosteroids in the blood plasma significantly rises, while the serotonin content in the hypothalamus decreases. A direct correlation between the changes in the emotional stress and the content of corticosteroids in blood plasma is noted. The effects of ethymisol partially persists after adrenalectomy. Ethymisol in optimal doses may be used for regulation and lowering of emotional stress.

[Effect of monoamines microinjected into the amygdaloid nucleus on the lateral hypothalamic self-stimulation response]. / Vliianie monoaminov, mikroapplitsirovannykh v iadra amigdaly, na reaktsiiu samorazhdrazheniia lateral'nogo gipotalamusa.

The effect of serotonin and noradrenaline injections in the amygdalar nuclei on the reaction of self-stimulation of the lateral hypothalamus was studied in rats. The increase of exogenous serotonin level in the amygdala phasically intensified the self-stimulation and activated emotionally negative forms of behaviour. The increase of noradrenaline content phasically lowered the frequency of self-stimulation and evoked emotionally positive forms of behaviour which did not depend on the lateral hypothalamus stimulation. It is supposed that the amygdala takes part in the mechanism of sensory reinforcement connected with learning and being in definite relations with the centres of positive reinforcement of the lateral hypothalamus, while amygdalar monoamines form the neurochemical basis for the control of the reinforcing properties of external stimuli.