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1.

Structure and Mechanisms of Assembly-Line Polyketide Synthases.

Soohoo, Alexander M; Cogan, Dillon P; Brodsky, Krystal L; Khosla, Chaitan.

Annu Rev Biochem ; 2024 Apr 25.

Artículo Inglés | MEDLINE | ID: mdl-38663033

2.

Genetic Mapping and Biochemical Basis of Yellow Feather Pigmentation in Budgerigars.

Cooke, Thomas F; Fischer, Curt R; Wu, Ping; Jiang, Ting-Xin; Xie, Kathleen T; Kuo, James; Doctorov, Elizabeth; Zehnder, Ashley; Khosla, Chaitan; Chuong, Cheng-Ming; Bustamante, Carlos D.

Cell ; 171(2): 427-439.e21, 2017 Oct 05.

Artículo Inglés | MEDLINE | ID: mdl-28985565

3.

IL-15, gluten and HLA-DQ8 drive tissue destruction in coeliac disease.

Abadie, Valérie; Kim, Sangman M; Lejeune, Thomas; Palanski, Brad A; Ernest, Jordan D; Tastet, Olivier; Voisine, Jordan; Discepolo, Valentina; Marietta, Eric V; Hawash, Mohamed B F; Ciszewski, Cezary; Bouziat, Romain; Panigrahi, Kaushik; Horwath, Irina; Zurenski, Matthew A; Lawrence, Ian; Dumaine, Anne; Yotova, Vania; Grenier, Jean-Christophe; Murray, Joseph A; Khosla, Chaitan; Barreiro, Luis B; Jabri, Bana.

Nature ; 578(7796): 600-604, 2020 02.

Artículo Inglés | MEDLINE | ID: mdl-32051586

4.

Past, Present, and Future of Noninvasive Tests to Assess Gluten Exposure, Celiac Disease Activity, and End-Organ Damage.

Silvester, Jocelyn A; Elli, Luca; Khosla, Chaitan; Tye-Din, Jason A.

Gastroenterology ; 2024 Apr 24.

Artículo Inglés | MEDLINE | ID: mdl-38670279

5.

Carnitine octanoyltransferase is important for the assimilation of exogenous acetyl-L-carnitine into acetyl-CoA in mammalian cells.

Hsu, Jake; Fatuzzo, Nina; Weng, Nielson; Michno, Wojciech; Dong, Wentao; Kienle, Maryline; Dai, Yuqin; Pasca, Anca; Abu-Remaileh, Monther; Rasgon, Natalie; Bigio, Benedetta; Nasca, Carla; Khosla, Chaitan.

J Biol Chem ; 299(2): 102848, 2023 02.

Artículo Inglés | MEDLINE | ID: mdl-36587768

6.

Discovery and Characterization of the Fully Decorated Nocardiosis-Associated Polyketide Natural Product.

Kishore, Shreya; Del Rio Flores, Antonio; Lynch, Stephen R; Yuet, Kai P; Khosla, Chaitan.

J Am Chem Soc ; 146(6): 4212-4220, 2024 Feb 14.

Artículo Inglés | MEDLINE | ID: mdl-38295028

7.

Engineering site-selective incorporation of fluorine into polyketides.

Sirirungruang, Sasilada; Ad, Omer; Privalsky, Thomas M; Ramesh, Swetha; Sax, Joel L; Dong, Hongjun; Baidoo, Edward E K; Amer, Bashar; Khosla, Chaitan; Chang, Michelle C Y.

Nat Chem Biol ; 18(8): 886-893, 2022 08.

Artículo Inglés | MEDLINE | ID: mdl-35817967

8.

GRINS: Genetic elements that recode assembly-line polyketide synthases and accelerate their diversification.

Nivina, Aleksandra; Herrera Paredes, Sur; Fraser, Hunter B; Khosla, Chaitan.

Proc Natl Acad Sci U S A ; 118(26)2021 06 29.

Artículo Inglés | MEDLINE | ID: mdl-34162709

9.

Discovery and Characterization of Antibody Probes of Module 2 of the 6-Deoxyerythronolide B Synthase.

Guzman, Katarina M; Cogan, Dillon P; Brodsky, Krystal L; Soohoo, Alexander M; Li, Xiuyuan; Sevillano, Natalia; Mathews, Irimpan I; Nguyen, Khanh P; Craik, Charles S; Khosla, Chaitan.

Biochemistry ; 62(11): 1589-1593, 2023 06 06.

Artículo Inglés | MEDLINE | ID: mdl-37184546

10.

Evaluation of Acebilustat, a Selective Inhibitor of Leukotriene B4 Biosynthesis, for Treatment of Outpatients With Mild-Moderate Coronavirus Disease 2019: A Randomized, Double-Blind, Placebo-Controlled Phase 2 Trial.

Levitt, Joseph E; Hedlin, Haley; Duong, Sophie; Lu, Di; Lee, Justin; Bunning, Bryan; Elkarra, Nadia; Pinsky, Benjamin A; Heffernan, Eileen; Springman, Eric; Moss, Richard B; Bonilla, Hector F; Parsonnet, Julie; Zamanian, Roham T; Langguth, Jamison J; Bollyky, Jenna; Khosla, Chaitan; Nicolls, Mark R; Desai, Manisha; Rogers, Angela J.

Clin Infect Dis ; 77(2): 186-193, 2023 07 26.

Artículo Inglés | MEDLINE | ID: mdl-36996150

11.

Targeted Lysosomal Degradation of Secreted and Cell Surface Proteins through the LRP-1 Pathway.

Loppinet, Elise; Besser, Harrison A; Lee, Christina E; Zhang, Wei; Cui, Bianxiao; Khosla, Chaitan.

J Am Chem Soc ; 145(34): 18705-18710, 2023 08 30.

Artículo Inglés | MEDLINE | ID: mdl-37590164

12.

Latiglutenase Protects the Mucosa and Attenuates Symptom Severity in Patients With Celiac Disease Exposed to a Gluten Challenge.

Murray, Joseph A; Syage, Jack A; Wu, Tsung-Teh; Dickason, Matthew A; Ramos, Ana G; Van Dyke, Carol; Horwath, Irina; Lavin, Philip T; Mäki, Markku; Hujoel, Isabel; Papadakis, Konstantinos A; Bledsoe, Adam C; Khosla, Chaitan; Sealey-Voyksner, Jennifer A.

Gastroenterology ; 163(6): 1510-1521.e6, 2022 12.

Artículo Inglés | MEDLINE | ID: mdl-35931103

13.

Structure-Based Prototyping of Allosteric Inhibitors of Human Uridine/Cytidine Kinase 2 (UCK2).

Mashayekh, Siavash; Stunkard, Lee M; Kienle, Maryline; Mathews, Irimpan I; Khosla, Chaitan.

Biochemistry ; 61(21): 2261-2266, 2022 11 01.

Artículo Inglés | MEDLINE | ID: mdl-36190114

14.

Favipiravir for Treatment of Outpatients With Asymptomatic or Uncomplicated Coronavirus Disease 2019: A Double-Blind, Randomized, Placebo-Controlled, Phase 2 Trial.

Holubar, Marisa; Subramanian, Aruna; Purington, Natasha; Hedlin, Haley; Bunning, Bryan; Walter, Katharine S; Bonilla, Hector; Boumis, Athanasia; Chen, Michael; Clinton, Kimberly; Dewhurst, Liisa; Epstein, Carol; Jagannathan, Prasanna; Kaszynski, Richard H; Panu, Lori; Parsonnet, Julie; Ponder, Elizabeth L; Quintero, Orlando; Sefton, Elizabeth; Singh, Upinder; Soberanis, Luke; Truong, Henry; Andrews, Jason R; Desai, Manisha; Khosla, Chaitan; Maldonado, Yvonne.

Clin Infect Dis ; 75(11): 1883-1892, 2022 11 30.

Artículo Inglés | MEDLINE | ID: mdl-35446944

15.

A genome-wide analysis of targets of macrolide antibiotics in mammalian cells.

Gupta, Amita; Ökesli-Armlovich, Aye; Morgens, David; Bassik, Michael C; Khosla, Chaitan.

J Biol Chem ; 295(7): 2057-2067, 2020 02 14.

Artículo Inglés | MEDLINE | ID: mdl-31915244

16.

An Unusual "OR" Gate for Allosteric Regulation of Mammalian Transglutaminase 2 in the Extracellular Matrix.

Melkonian, Arek V; Loppinet, Elise; Martin, Renata; Porteus, Matthew; Khosla, Chaitan.

J Am Chem Soc ; 143(28): 10537-10540, 2021 07 21.

Artículo Inglés | MEDLINE | ID: mdl-34232639

17.

Prospects for Antibacterial Discovery and Development.

Privalsky, Thomas M; Soohoo, Alexander M; Wang, Jinhua; Walsh, Christopher T; Wright, Gerard D; Gordon, Eric M; Gray, Nathanael S; Khosla, Chaitan.

J Am Chem Soc ; 143(50): 21127-21142, 2021 12 22.

Artículo Inglés | MEDLINE | ID: mdl-34860516

18.

Properties of a "Split-and-Stuttering" Module of an Assembly Line Polyketide Synthase.

Guzman, Katarina M; Yuet, Kai P; Lynch, Stephen R; Liu, Corey W; Khosla, Chaitan.

J Org Chem ; 86(16): 11100-11106, 2021 08 20.

Artículo Inglés | MEDLINE | ID: mdl-33755455

19.

Evolution and Diversity of Assembly-Line Polyketide Synthases.

Nivina, Aleksandra; Yuet, Kai P; Hsu, Jake; Khosla, Chaitan.

Chem Rev ; 119(24): 12524-12547, 2019 12 26.

Artículo Inglés | MEDLINE | ID: mdl-31838842

20.

Interleukin 4 is inactivated via selective disulfide-bond reduction by extracellular thioredoxin.

Plugis, Nicholas M; Weng, Nielson; Zhao, Qinglan; Palanski, Brad A; Maecker, Holden T; Habtezion, Aida; Khosla, Chaitan.

Proc Natl Acad Sci U S A ; 115(35): 8781-8786, 2018 08 28.

Artículo Inglés | MEDLINE | ID: mdl-30104382

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