RESUMEN
Appropriate knowledge and actions of residents in housing are expected to reduce health effects, defined as "living literacy." With the spread of COVID-19 and the diversification of lifestyles, a quantitative evaluation of a comprehensive model that includes living literacy in the housing environment is required. In this study, the author conducted two web-based surveys of approximately 2000 different households in Japan during the summer of 2020 and winter of 2021, and a statistical analysis based on the survey results. As a result, ventilation by opening windows was observed as a new resident behavior trend under COVID-19. In addition, structural equation modeling using the survey samples confirmed the certain relationship between living literacy and subjective evaluation of the indoor environment and health effects in both periods.
Asunto(s)
COVID-19 , Alfabetización en Salud , Estilo de Vida , Modelos Teóricos , Humanos , Contaminación del Aire Interior/análisis , COVID-19/epidemiología , Vivienda , Japón/epidemiología , Encuestas y Cuestionarios , Conducta , Estaciones del AñoRESUMEN
The asymmetric total synthesis of toxicodenane A, a sesquiterpenoid expected to be promising for diabetic nephropathy, was achieved. In the synthesis, a samarium iodide (SmI2)-induced Barbier-type cyclization and a regio- and stereoselective allylic oxidation followed by a dehydration cyclization were employed as key steps. Furthermore, the first asymmetric syntheses of both enantiomers were accomplished using the previously mentioned synthetic strategy. Finally, the synthetic compounds significantly inhibited lipotoxicity-mediated inflammatory and fibrotic responses in mouse renal proximal tubular cells.