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Eur J Neurosci ; 48(3): 1964-1975, 2018 08.
Artículo en Inglés | MEDLINE | ID: mdl-30044019

RESUMEN

This is a case study involving a female patient (NN) with complete loss of autobiographical memory and identity despite normal neurological assessment. To test the hypothesis that patients with dissociative amnesia (DA) possess the ability to covertly process facial identities they are unaware of, we conducted functional magnetic resonance imaging (fMRI) and assessed skin conductance responses (SCR) to (a) strangers, (b) celebrities, and (c) familiar faces not seen since the onset of DA. We also performed associative face-name memory tasks to test the patient's ability to learn and recall newly learned face-name pairs. Although NN did not recognize any of the faces of her friends and relatives, their images triggered a stronger involvement of the left fusiform gyrus, the bilateral hippocampus/amygdala region, the orbitofrontal cortex, the middle temporal regions, and the precuneus, along with higher SCR. During recollection of previously learned face-name pairs, NN (compared to healthy controls) demonstrated a weaker involvement of the hippocampus. Our findings suggest that, in DA, specific arousal systems remain capable of being activated by familiar faces outside of conscious awareness. The decreased activation observed in the hippocampus demonstrates that the functioning of memory-sensitive regions may be impaired by trauma.


Asunto(s)
Amnesia/fisiopatología , Amnesia/psicología , Encéfalo/fisiopatología , Reconocimiento Facial/fisiología , Adulto , Anciano , Mapeo Encefálico , Femenino , Respuesta Galvánica de la Piel , Humanos , Imagen por Resonancia Magnética , Pruebas Neuropsicológicas , Reconocimiento en Psicología/fisiología
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