[Influence of modern dental materials on the oral mucosa]. / Vliyanie sovremennykh stomatologicheskikh materialov na slizistuyu obolochku polosti rta.

This article provides the current data of the modern literature on the question of the biocompatibility of dental materials, their influence on the local immune homeostasis of the oral cavity; influence of the method of transmission of masticatory load on the tissues and organs of the oral cavity. Thus, when installing the seal, the choice of material, the localization of carious lesions, and when prosthetics - the choice of material of the prosthetic structure and the method of transfer of chewing load is important. It should be understood that the reaction of the mucous membrane can be not only in the area of direct contact with the dental material, but also appear in remote areas of the oral mucosa.

[Variations of permanent teeth crowns shapes in children at the age of 14]. / Odontologicheskie variatsii form koronok postoyannykh zubov u detei 14 let.

The objective of the research was to determine odontological (odontometric and odontoscopic) and morpho-aesthetic variations of the upper central and lateral incisors in 14-year-old children residing in Udmurt Republic. 200 adolescent respondents (100 boys and 100 girls) were included in the study. We accessed morphological aspects of the permanent upper right and left central incisors (URCI and ULCI) in 14-year-old children born and permanently residing in conditionally ecologically favorable districts of the Udmurt Republic. Odontological variations of the permanent tooth crown shapes in early adolescent children (14-year-old) are shown; morphological, ethnic, age and gender, aesthetic features are determined. The determined odontoscopic and odontometric features of the permanent tooth crown shapes matter of scientific and practical terms and can be used to clarify ethnicity and possibly gender. The identified patterns can change and multiply the information-statistical interpretation of the ethnic and morpho-aesthetic features of the permanent teeth, and hence have an important impact when restoring damaged teeth crowns, which affect the permanent dentition smile harmony in 14-year-old adolescents born and permanently residing in the Udmurt Republic.

[The influence of dental status on local immunity of oral cavity of elderly and senile patients with squamous cell carcinoma of the oral cavity mucosa.]

This article presents the results of a study of the dental status of 60 elderly and senile patients with squamous cell carcinoma of the oral mucosa. The use of removable and non-removable dentures, carious lesions of teeth, dental plaque, sharp edges of the crown seals were studied as components of the dental status.

[Features of dental rehabilitation of elderly patients after treatment of maxillofacial neoplasm.]

The purpose of this study is a comparative analysis of the effectiveness of the use of dental trays-transformers for the manufacture of prosthetic designs for elderly patients with acquired microstomia. Was conducted a clinical study of 12 hemimaxillectomy patients from 60 to 72 years. The 1st group included 6 patients with acquired microstomia, impressions of the jaws were obtained with dental trays-transformers. The 2nd group includes 6 patients who have less traumatic oral opening, they were removed with standard dental trays. The group of clinical control consisted of 6 patients with partial absence of maxillary teeth, who needed to prosthetic dentistry. The results of the study indicate the effectiveness of the use of trays-transformers to impressions of the jaw in elderly patients with restricted oral opening, as well as in patients with normal oral opening. Optimization of the stages of obturator prostheses allows to provide qualitative prosthetic care of patients with malignant neoplasms of the oropharyngeal region, which has a positive effect on the quality of life of elderly patients with acquired defects of the oropharyngeal region.

Comparative Role of Matrixins in Diagnostics of Parotid Gland Tumors.

The benign and malignant neoplasms in parotid gland have similar clinical presentations despite different tumor growth rates. The study compared the clinical and morphological data as well as the results of ELISA for MMP-2, MMP-8, MMP-9, TIMP-1, and TIMP-2 in salivary fluid yielded during primary examination of the patients with pleomorphic adenoma and adenocarcinoma of parotid gland. The examined biomarkers detected in salivary fluid in patients with various cancer types differed significantly (p≤0.05). The correlations between clinical identification of adenoma or adenocarcinoma, on the one hand, and the levels of MMP-8, TIMP-1, and TIMP-2, on the other hand, makes it possible to use the latter as biomarkers for early detection and comprehensive noninvasive differential diagnostics of these neoplasms.

[Dental status as a predictive factor in the development of squamous cell carcinoma of the oral mucosa]. / Stomatologicheskii status kak prognosticheskii faktor razvitiia ploskokletochnogo raka slizistoi obolochki polosti rta.

The aim of this work was to study the influence of components of dental status on the local immunity of the oral cavity; we compared the results of the study of patients with squamous cell carcinoma (SCC) of the oral mucosa and patients without neoplasm. The study involved 136 patients with squamous cell carcinoma of the oral mucosa and 57 patients without neoplasms. In the role of the constituent characteristics of dental status were examined: the use of removable and fixed dentures, dental caries, dental plaque, sharp edges of fullings. Matrix metalloproteinases (MMPs) 2, 8 and 9, as well as their tissue inhibitors 1 and 2 were assessed in oral fluid. The results suggest the influence of all factors on local immune status of the oral cavity as proved by the significant changes in MMPs level. The use of removable dentures resulted in the pronounced decrease of MMPs and should be considered in oral SSC screening and non-invasive diagnostics.

[Radiation-associated changes in salivation of patients with cancer of maxillofacial region]. / Radioindutsirovannye izmeneniia sliunootdeleniia u patsientov so zlokachestvennymi novoobrazovaniiami cheliustno-litsevoi oblasti.

The radiation has an antitumor effect and causes radiation reactions and damage to surrounding tissues within the framework of combined antitumor treatment of patients with cancer of maxillofacial region. It also has an irreversible effect on the production of saliva by large and small salivary glands, and this must be taken into account when planning radiation therapy for this group of patients.

Matrixins in the Salivary Fluid of Patients with Tumors of the Maxillofacial Region during Orthopedic Rehabilitation with Different Prosthetic Structures.

Dental and immunological features of the influence of various prosthetic structures of orthopedic prostheses on tissues and organs of the maxillofacial region were evaluated by the parameters of expression of oral fluid biomarkers. Healthy people without tumor and somatic diseases and patients with neoplasms of maxillofacial area in need of dental rehabilitation were examined before and in 2 weeks and 3 months after treatment. Certain regularities in the reaction of biomarkers to orthopedic prostheses were observed: a decrease in activity of MMP-2 and MMP-8 and their inhibitors or an increase in MMP-9; an increase in activity of biomarkers at early terms and a decrease in delayed terms after prosthetics.

Estimation of Expression of Oral Fluid Biomarkers in the Diagnosis of Pretumor Diseases of Oral Mucosa.

Complex clinical, dental, and morphological investigation, and ELISA of levels of MMP-2, 8, 9, and TIMP-1 and 2 in the saliva was performed during primary examination of patients with premalignant lesions of maxillofacial area and practically healthy volunteers. Levels of all study MMP in the saliva significantly differed (p≤0.05) in patients with premalignant lesions and the control. These patients were also characterized by a significant (0.1≤p≤0.05) changes in TIMP concentrations (toward pathological pattern) comparing to the control. Pattern of correlations between parameters of MMP-2 expression might be a marker for early diagnostics of a premalignant lesion independently on the dental health. Observed features of biomarker expression in patients with premalignant lesions might reflect the appearance of a cascade of biochemical reactions followed by the activation of production of proteinases and their inhibitors as a response to the exposure to etiological factors. Clinical and morphological diagnosis of a premalignant lesion in the maxillofacial area was confirmed by the immunological analysis of biomarker expression in the saliva, which can be used for monitoring and screening of population.

[The influence of risk factors for malignant tumors of maxillo-facial area on the expression of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in patients of elderly and senile age period].

Morbidity and mortality from malignant neoplasms increases each year, and the average age of patients with first diagnosed decreases. The peak of incidence of malignant tumors of maxillofacial region falls on the elderly life. Not only age-related changes of the organism contribute in the development of this pathology, but also harmful habits. A comprehensive approach to solving the problem requires monitoring of this group of patients to identify risk factors for the development of pathologies in the oral and maxillofacial region.

[The diagnostic possibilities of saliva].

Saliva is a clinically informative biological fluid which contains multitude of bio-markers. This characteristic makes it possible to carry out numerous analyzes for developing mode to test patient in situ, express-tests included. The diagnostic by saliva is a new area of more simple application both markers and analyzers that can be useful in diagnostic of diseases of oral cavity, oncological diseases included. The using of saliva expands perspectives for making clinical diagnosis and establishment of dynamics and monitoring of disease.