[Regulation of calcium metabolism in hypertension]. / Reguliatsiia obmena kal'tsiia pri gipertonicheskoi bolezni.

In patients with hypertensive disease, the intravenous calcium tolerance test revealed a delayed elimination of loading hypercalcemia, which totally reflects the effectiveness mechanisms aimed at removing excessive calcium from the extracellular space. In hypertensives, renal calcium excretion was also delayed due to a lower suppression of calcium channel reabsorption. The patients showed a greater background concentration of parathyroid hormone (PTH) and during the calcium tolerance test a much lower PTH levels and higher calcitonin concentrations, though their homeostatic effects remained inadequate due to their diminished sensitivity of target organs. Thus, there was an increase in the activity of parathyroidal glands in patients with hypertensive disease.

[Secondary prevention of arterial hypertension in an organized population: methods of implementation, efficacy, prospects]. / Vtorichnaia profilaktika arterial'noi gipertonii v organizovannoi populiatsii: puti realizatsii, éffektivnost', perspektivy.

Five-year follow-up of an organized population of males between 35 and 54 years of age and medication of patients with arterial hypertension (AH) demonstrated possibilities of considerably reducing the incidence of cerebral insult (by 42.9%) and myocardial infarction (by 15.5%) and the respective mortality rates (by 56.1% and 23.8%), invalidism associated with cardiovascular diseases (by 36%), temporary disability because of AH (by 38.2%). The efficiency of treatment for AH increases considerably where medication is given on a regular basis. Possible approaches to improving the efficiency of secondary AH prevention within an organized population are discussed, as are possibilities of introducing preventive measures in routine work of the factory therapeutic service.

[The use of the television microscopicanalysis for the serodiagnosis of salmonellosis and brucellosis]. / Ispol'zovanie metoda televizionnogo mikroskopicheskogo analiza dlia serodiagnostiki sal'monelleza i brutselleza.

The possibility of using TV microscopic analysis for the laboratory diagnosis of salmonellosis and brucellosis is considered. The comparative analysis of this method and standard serodiagnostic methods was made in the study of sera taken from 134 salmonellosis patients 69 chronic brucellosis patients. The study demonstrated the advantages of the method of MIA (rapidity, high sensitivity, specificity), making it possible to recommend its wide use for the laboratory diagnosis of salmonellosis and brucellosis.

[Calciuretic renal function in patients with essential hypertension]. / Kal'tsiiureticheskaia funktsiia pochek u bol'nykh gipertonicheskoi bolezn'iu.

Under the conditions of standard and customary calcium use, patients suffering from essential hypertension (EH) do not manifest any changes in calciuresis either at the expense of the glomerular or tubular mechanisms. After intravenous hypercalcemic injections EH patients demonstrate well-defined disorders in calciuretic renal function, caused by inadequate suppression of tubular reabsorption of calcium by parathyroid hormone (PTH). The hormonal-renal correlations in EH patients differ from those in normals. More pronounced alterations in the concentration of radioimmune PTH and calcitonin under acute hypercalcemia are not associated with an adequate increment of fractional excretion of calcium whereas the calciuretic effect of exogenous calcium-regulating hormones (CRH) realized at the tubular level is less remarkable. Therefore EH patients manifest changes not only in CRH secretion but also in the sensitivity to them of the renal tubules. White changing parathyroid regulation of calcium metabolism prolonged administration of calcium to EH patients enhances body capabilities of resisting acute alterations in calcemia because of normalization of calciuretic renal function, especially tubular calcium transport. In addition, it lowers arterial pressure and enables reduction of the dose of calcium antagonists used in the treatment of EH.

[The possibility of targeted pharmacological action on the intravascular binding of calcium ions: a new aspect of pharmacodynamics?]. / O vozmozhnosti napravlennogo farmakologicheskogo vozdeistviia na vnutrisosudistoe sviazyvanie ionov kal'tsiia: novyi aspekt farmakodinamiki?

The administration of cardiac glycosides (digoxin, strophanthin, corglycon) invariably produced a calcium ionizing effect raising the content of blood serum ionized calcium and a degree of serum calcium ionization. Calcium transport antagonists (verapamil, nifedipine) made a reverse effect (a calcium-binding effect). Both effects were noted 5-15 min, after administration of the drugs disappearing in 60-90 min. They were reproduced after adding digoxin, strophanthin and verapamil to the blood serum in vitro but they were not summarized and probably did not depend on a basal level of calcemia. Under the influence of digoxin blood serum calcium binding capacity was on a regular decrease whereas under the influence of verapamil and nifedipine it was on an increase. Close negative correlation was found between shifts of blood serum calcium binding capacity and a degree of serum calcium ionization.

[The effect of calcium-regulating hormones on the renal transport of calcium in hypertension]. / Vliianie kal'tsiireguliruiushchikh gormonov na pochechnyi transport kal'tsiia pri gipertonicheskoi bolezni.

Enhanced and diminished calcemia following administration of parathormone and calcitonin in hypertensive patients, respectively, were found not to differ from relevant values in healthy subjects. Calciuretic effect of parathormone results from its action on the bone and renal calcium transport. Quantitatively, the effects on the bone and renal calcium transport. Quantitatively, the effects on the bone presenting as elevated calcemia and calcium filtration capacity, its excreted fraction and renal excretion prevail, being less pronounced in hypertensive patients. A direct renal effect of parathyroid hormone indicated by stimulation of calcium tubular reabsorption is weaker in hypertensive subjects. Calcitonin administration inhibits tubular calcium reabsorption in the less degree in hypertensive subjects. The disorders in calciuretic function of the kidney in hypertension are secondary to reduced kidney sensitivity to the action of calcium regulating hormones.

[Effect of nifedipine on renal activity]. / Vliianie nifedipina na deiatel'nost' pochek.

Sublingual administration of nifedipine (N) at a dose of 20 mg to 8 persons without cardiovascular and renal pathology and to 19 patients with congestive heart failure (CHF) increased renal excretion of sodium (by an average of 51.1-132.8%), water (by an average of 31.7-101.9%), potassium (by an average of 43.2-63.2%) and calcium (by an average of 118%). The natriuretic effect of N appeared in 20 min reaching its maximum in 45-60 min, being more noticeable in CHF. An increment of natriuresis resulted from a decrease in sodium tubular reabsorption (correlation factor--0.92) rather than from an increase in glomerular filtration (correlation factor +0.50). N suppressed sodium reabsorption in the proximal tubule (by an average of 34.1%) as well as in the segment, more distal of Henle's loop (by an average of 6.8%). N might suppress directly calcium-dependent mechanisms of sodium transtubular transport but it could also produce a mediated effect as a result of shifts of renal hemodynamics.

[Treatment of mild and moderate hypertension with enalapril (multicenter study of enap and enap N in Ukraine)]. / Lechenie miagkoi i umerennoi arterial'noi gipertonii énalaprilom (mnogotsentrovoe issledovanie énapa i énapa-N na Ukraine).

AIM: Assessment of efficiency and safety of enalapril (enap) and its combination with hydrochlorotiaside (enap-N). MATERIALS AND METHODS: 127 patients with mild and moderate blood hypertension entered an open non-comparative multicenter trial. 60 of them received enap (group 1), 67--enap N (group 2). Group 1 patients were given enap for 2 weeks in a dose 10 mg/day. If this dose was not adequate to normalize blood pressure, it was raised to 20-40 mg/day. Patients of group 2 received enap-N one tablet a day for 3 weeks. If the pressure persisted higher than 140/90 mm Hg, the treatment was continued for 3 weeks more in a dose of 2 tablets a day. RESULTS: Blood pressure lowered under 140/90 mm Hg in 40 patients of group 1 (66.7%). Systolic pressure dropped by 10 mm Hg minimum and diastolic by 5 mm minimum in 18 group 1 patients (30%). Enap-N reduced blood pressure under 140-90 mm Hg in 44 of 67 patients (65.7%). Systolic and diastolic pressure dropped, respectively, in 23(34.3%) patients. CONCLUSION: Enap and enap-N tablets were found highly effective and well tolerated. Side effects were caused by lowering of blood pressure.

[Urinary potassium excretion in chronic heart failure]. / Kaliiurez pri khronicheskoi serdechnoi nedostatochnosti.

Mechanisms were studied of urinary potassium excertion in patients with chronic heart failure (CHF). A total of 78 patients were examined presenting with functional class I-IV CHF.

[Relation between calcium intake with food and arterial pressure in metallurgists of Donbass]. / Vzaimosviaz' potrebleniia kal'tsiia s pishchei i urovnia arterial'nogo davleniia u metallurgov Donbassa.

Food rations and 24-hour urinary excretion of calcium were evaluated in 1100 metallurgists and revealed a distinct relationship between low consumption of calcium with food due to reduced intake of milk products and the incidence of elevated arterial pressure levels. This relationship did not depend on age and professional factors.