RESUMEN
The effect of glucosamine sulfate on the analgesic properties and ulcerogenic action of ketoprofen has been experimentally studied in the course of drug adminstration in laboratory animals in comparison to the ketoprofen monotherapy. An analysis of the results shows that the combined application of glucosamine sulfate with ketoprofen produces a twofold increase in the analgesic activity of ketoprofen and decreases the drug-induced damage of the stomach mucous membrane. These effects are especially pronounced for the following ratio of components: ketoprofen, 16 or 24 mg/kg; glucosamine sulfate, 125 mg/kg.
Asunto(s)
Analgésicos no Narcóticos/farmacología , Antiinflamatorios no Esteroideos/farmacología , Glucosamina/farmacología , Cetoprofeno/farmacología , Umbral del Dolor/efectos de los fármacos , Úlcera Gástrica/prevención & control , Analgésicos no Narcóticos/toxicidad , Animales , Antiinflamatorios no Esteroideos/toxicidad , Cetoprofeno/toxicidad , Masculino , Dimensión del Dolor , Ratas , Ratas Wistar , Úlcera Gástrica/inducido químicamenteRESUMEN
Whether the prolonged action of the topical anesthetics trimecaine and pirbentan can be achieved by using inclusion compounds was studied. beta-Cyclodextrin was used as an agent containing topical anesthetics in its molecule. In in vitro and in vivo experiments, the inclusion compounds trimecaine and pirbentan with beta-cyclodextrin produced a more prolonged action in terminal anesthesia than the compounds used alone.