[Pilot study in the rat of the applicability of the refractory period of peripheral nerves as a biosensor for insulin-induced hypoglycemia]. / Pilotstudie an der Ratte zur Verwendbarkeit der Refraktärzeit (RZ) des peripheren Nerven als Biosensor für eine insulinbedingte Hypoglykämie.

Different points of view have been reported with respect to a possible correlation between nerve conduction velocity, refractory period and blood glucose level. In the present study we investigated whether the refractory period is correlated with the blood glucose level or not. Our results did not show any correlation of the refractory period with the blood glucose level.

[Effect of a fixed betablocker diuretic combination in hypertension compared with the effect of the single components (author's transl)]. / Wirkung einer fixen Beta-Blocker-Thiazid-Kombination bei der Behandlung der Hypertonie, verglichen mit der Wirkung der Einzelkomponenten.

In a double blind designed treatment trial with three randomized groups of patients the effect of a fixed betablocker diuretic combination (Torrat, Boehringer Mannheim GmbH) was compared with the effect of the single components. 66 patients with essential and renal hypertension stage I and II according to the WHO definition were evaluated. 27 patients were treated with 1 tablet, 32 with 2 X 1 tablet, and 7 patients with 3 X 1 tablet daily. Besides of the blood pressure lowering effect over an observation period of 10 weeks the influence on pulse rate, potassium, blood sugar and uric acid were investigated. It could be shown that the blood pressure lowering effect was highest under the combination-drug. The treatment with the single components showed a less pronounced influence on the blood pressure, thus hinting at an additive effect of the 2 components metipranolol and butizide when given together. The combination exerts few side effects and does not influence the investigated parameters of metabolism over a longer period of time.