RESUMEN
Serum and CSF from 48 patients with amyotrophic lateral sclerosis and six patients with late-onset postpoliomyelitis progressive muscular atrophy were investigated for the presence of antibody to poliovirus types 1, 2, and 3, coxsackie viruses B3 and B4, influenza A, measles, rubella, mumps, herpes simplex types 1 and 2, cytomegalovirus, varicella-zoster, and Toxoplasma gondii. These results were compared with those from 53 control patients with neuromuscular disease matched for age, sex, race, and poliovirus vaccine exposure. There was no difference either in distribution of serum or CSF antibody titers or the geometric-mean antibody titers. There was no evidence suggesting the presence of locally produced specific viral antibody within the CNS to any of the agents studied. In particular, there was no serological evidence to suggest an association between persistent infection with any poliovirus type and amyotrophic lateral sclerosis or late-onset postpoliomyelitis progressive muscular atrophy.
Asunto(s)
Esclerosis Amiotrófica Lateral/líquido cefalorraquídeo , Anticuerpos Antivirales/líquido cefalorraquídeo , Atrofia Muscular/líquido cefalorraquídeo , Poliomielitis/complicaciones , Adulto , Citomegalovirus/inmunología , Enterovirus Humano B/inmunología , Femenino , Herpesvirus Humano 3/inmunología , Humanos , Virus de la Influenza A/inmunología , Masculino , Persona de Mediana Edad , Virus de la Parotiditis/inmunología , Atrofia Muscular/complicaciones , Poliovirus/inmunología , Virus de la Rubéola/inmunología , Simplexvirus/inmunología , Toxoplasma/inmunologíaRESUMEN
Several groups have reported a relation between herpesvirus hominis infection and certain psychiatric disorders. We have investigated herpes antibody levels in chronic criminal offenders who were diagnosed as defective delinquents and in criminals who were not defective delinquents. We found no difference in the frequency of titers of herpesvirus type I or type 2 antibody in these groups.
Asunto(s)
Anticuerpos Antivirales/análisis , Trastorno de Personalidad Antisocial/etiología , Infecciones por Herpesviridae/complicaciones , Prisioneros , Simplexvirus/inmunología , Adolescente , Adulto , Trastorno de Personalidad Antisocial/inmunología , Crimen , Humanos , Delincuencia Juvenil , Masculino , Persona de Mediana Edad , PsicopatologíaRESUMEN
The authors present the initial and follow-up MR findings in a patient with subacute combined degeneration of the spinal cord, a complication of vitamin B12 deficiency, and a rare cause of demyelination of the dorsal and lateral columns of the spinal cord. Initial study showed high intensity in the dorsal columns of the cervical and thoracic spinal cord on T2-weighted image. Five months after treatment, the abnormal signal intensity was noted to have decreased.