High-Resolution Mass Spectrometry Screening of Quaternary Ammonium Compounds (QACs) in Dust from Homes and Various Microenvironments in South China.

Despite their ubiquitous use, information regarding the presence of quaternary ammonium compounds (QACs) in various microenvironments remains scarce and only a small subset of QACs has been monitored using targeted chemical analysis. In this study, a total of 111 dust samples were collected from homes and various public settings in South China during the COVID-19 pandemic and were analyzed for traditional and emerging QACs using high-resolution mass spectrometry. The total traditional QAC concentrations in residential dust (∑traditional QAC, sum of 18 traditional QACs) ranged from 13.8 to 150 µg/g with a median concentration of 42.2 µg/g. Twenty-eight emerging QACs were identified in these samples, and the composition of ∑emerging QAC (sum of emerging QACs) to ∑QAC (sum of traditional and emerging QACs) ranged from 19 to 42% across various microenvironments, indicating the widespread existence of emerging QACs in indoor environments. Additionally, dust samples from cinemas exhibited higher ∑QAC concentrations compared to homes (medians 65.9 µg/g vs 58.3 µg/g, respectively), indicating heavier emission sources of QACs in these places. Interestingly, significantly higher ∑QAC concentrations were observed in dust from the rooms with carpets than those without (medians 65.6 µg/g vs 32.6 µg/g, p < 0.05, respectively). Overall, this study sheds light on the ubiquitous occurrence of QACs in indoor environments in South China.

Occurrence, sources, and human exposure assessment of amine-based rubber additives in dust from various micro-environments in South China.

Despite the ubiquitous use and potential health effects of amine-based rubber additives, information regarding their occurrences in indoor environments remains scarce and is basically investigated in traffic-related environments. In this study, a total of 140 dust samples collected from eight indoor micro-environments were analyzed for twelve amine-based rubber additives. Overall, 1,3-diphenylguanidine (DPG), dicyclohexylamine (DCHA), N-(1,3-dimethylbutyl)-N'-phenyl-p-penylenediamine (6PPD), 6PPD-quinone (6PPDQ), and hexa(methoxymethyl)melamine (HMMM) were frequently detected across all micro-environments with detection frequencies of 97 %, 51 %, 71 %, 99 %, and 77 %, respectively. The highest total concentration of amine-based rubber additives was found in parking lots (median 10,300 ng/g), indicating heavier emission sources of these compounds in vehicle-related indoor environments. Despite this, amine-based rubber additives were also frequently detected in various non-vehicle-related environments, such as markets, cinemas, and hotels, probably due to the widespread use of consumer products and more frequent air exchanges with outdoor environments. Further tracking of tire rubber products and paint particles from flooring materials in parking lots revealed that paint particles might be an overlooked contributor to amine-based rubber additives in indoor environments. Finally, the highest estimated daily intakes (EDIs) of all amine-based rubber additives via dust ingestion at home were observed for toddlers (3.48 ng/kg bw/d). This research provides a comprehensive overview of human exposure to a variety of amine-based rubber additives in various indoor environments. ENVIRONMENTAL IMPLICATION: This study highlights the presence of high concentrations of amine-based additives in indoor dust from both traffic-related and non-traffic-related indoor environments. Additional efforts are needed to identify potential sources of amine-based rubber additives indoors, beyond just tire rubber. This is critical because the widespread presence of rubber products in indoor settings could pose a risk to human health.