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It is generally believed that at-Γ bound states in the continuum (BICs) are enclosed by a linearly polarized vortex in momentum space when the structures have mirror (σz) symmetry, in-plane inversion (I) symmetry, and time reversal symmetry (T). Here, we reveal an anomalous situation in which at-Γ BICs can be enclosed by linearly and elliptically polarized far-field even when the σz, I, and T symmetries are all maintained in non-Bravais lattices, which is radically different from previous cognition. Asymmetric, diatomic structures are designed to elaborate this intriguing phenomenon. By controlling the geometric parameters or refractive indexes of the two meta-atoms, the far-field polarization around the at-Γ BICs gradually deviates from linear polarization and approaches circular polarization. Our findings reveal that non-Bravais lattices can provide a novel platform to manipulate the far-field polarization, showing important applications in quantum entanglement, structured light, and radiation modulation.
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The numerical aperture (NA) of a lens determines its focusing resolution capability and the maximum light collection or emission angle. In this Letter, an ultrathin high NA metalens operating in the microwave band is designed and demonstrated both numerically and experimentally. The proposed element is constructed by a multi-layer complementary split ring resonator, which can cover full 2π phase shift simultaneously with high transmission magnitude by varying its radius gradually. The numerical and experimental results reveal that the designed ultrathin (thickness is only â¼0.23λ) metalens can focus normal incident microwave efficiently to a spot of full width at half-maximum (FWHM) as small as â¼0.54λ with a corresponding high NA exceeding 0.9. Besides, the high NA metalens also possesses a relatively large focusing efficiency with a peak 48% within considered broad frequency range from 7.5 to 10 GHz. The performances of the presented metalens can be comparable or even superior to nowadays high-quality optical metalenses and represent an important step to develop a high-performance metalens in low spectrum. Besides, it can greatly facilitate the development of some novel miniaturized devices like a high-gain low profile scanning antenna, an ultra-compact retroreflector, and cloaks.
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A novel metal matrix composite based on the NbMoCrTiAl high entropy alloy (HEA) was designed by the in-situ formation method. The microstructure, phase evolution, and compression mechanical properties at room temperature of the composite are investigated in detail. The results confirmed that the composite was primarily composed of body-centered cubic solid solution with a small amount of titanium carbides and alumina. With the presence of approximately 7.0 vol. % Al2O3 and 32.2 vol. % TiC reinforced particles, the compressive fracture strength of the composite (1542 MPa) was increased by approximately 50% compared with that of the as-cast NbMoCrTiAl HEA. In consideration of the superior oxidation resistance, the P/M NbMoCrTiAl high entropy alloy composite could be considered as a promising high temperature structural material.
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Random media pose limitations on the imaging capability of photoelectric detection devices. Currently, imaging techniques employed through random media primarily operate within the laser wavelength range, leaving the imaging potential of terahertz waves unexplored. In this study, we present an approach for terahertz bistatic three-dimensional imaging (TBTCI) of hidden objects through random media. By deducing the field distribution of bistatic terahertz time-domain spectroscopy system, and proposing an explicit point spread function of the random media, we conducted three-dimensional imaging of hidden objects obscured by the random media. Our proposed method exhibits promising applications in imaging scenarios with millimeter-wave radar, including non-invasive testing and biological imaging.
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In this paper, both fundamental SSP modes on a roofed metallic grating and its effective excitation of the bounded SSP mode by an injected electron beam on the structure are numerically examined and investigated in the THz regime. Apart from the bounded SSP mode on the metallic grating with open space, the introduced roofed metallic grating can generate a closed waveguide mode that occupies the dispersion region outside the light line. The closed waveguide mode shifts gradually to a higher frequency band with a decreased gap size, while the bounded SSP mode line becomes lower. The effective excitation of the bounded SSP mode on this roofed metallic grating is also implemented and studied by using a particle-in-cell simulation studio. The output SSP power spectrums with various gap sizes by the same electron beam on this roofed metallic grating are obtained and analyzed. The simulation results reveal that the generated SSP spectra show a slight red shift with a decreased gap size. This work on the excitation of the SSP mode using an electron beam can benefit the development of high-power compact THz radiation sources by utilizing the strong near-field confinement of SSPs on metallic gratings.
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Non-Hermitian quantum metrology, an emerging field at the intersection of quantum estimation and non-Hermitian physics, holds promise for revolutionizing precision measurement. Here, we present a comprehensive investigation of non-Hermitian quantum parameter estimation in the quantum regime, with a special focus on achieving Heisenberg scaling. We introduce a concise expression for the quantum Fisher information (QFI) that applies to general non-Hermitian Hamiltonians, enabling the analysis of estimation precision in these systems. Our findings unveil the remarkable potential of non-Hermitian systems to attain the Heisenberg scaling of 1/t, where t represents time. Moreover, we derive optimal measurement conditions based on the proposed QFI expression, demonstrating the attainment of the quantum Cramér-Rao bound. By constructing non-unitary evolutions governed by two non-Hermitian Hamiltonians, one with parity-time symmetry and the other without specific symmetries, we experimentally validate our theoretical analysis. The experimental results affirm the realization of Heisenberg scaling in estimation precision, marking a substantial milestone in non-Hermitian quantum metrology.
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In this study, we explore the quantum critical phenomena in generalized Aubry-André models, with a particular focus on the scaling behavior at various filling states. Our approach involves using quantum fidelity susceptibility to precisely identify the mobility edges in these systems. Through a finite-size scaling analysis of the fidelity susceptibility, we are able to determine both the correlation-length critical exponent and the dynamical critical exponent at the critical point of the generalized Aubry-André model. Based on the Diophantine equation conjecture, we can determines the number of subsequences of the Fibonacci sequence and the corresponding scaling functions for a specific filling fraction, as well as the universality class. Our findings demonstrate the effectiveness of employing the generalized fidelity susceptibility for the analysis of unconventional quantum criticality and the associated universal information of quasiperiodic systems in cutting-edge quantum simulation experiments.
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As an ideal drug carrier, it should possess high drug loading and encapsulation efficiency and precise drug targeting release. Herein, we utilized a template-guided self-weaving technology of phase-separated silk fibroin (SF) in reverse microemulsion (RME) to fabricate a kind of hyaluronic acid (HA) coated SF nanocage (HA-gNCs) for drug delivery of cancer immunotherapy. Due to the hollow structure, HA-gNCs were capable of simultaneous encapsulation of the anti-inflammatory drug betamethasone phosphate (BetP) and the immune checkpoint blockade (ICB) agent PD-L1 antibody (αPD-L1) efficiently. Another point worth noting was that the thiocarbonate cross-linkers used to strengthen the SF shell of HA-gNCs could be quickly broken by overexpressed glutathione (GSH) to reach responsive drug release inside tumor tissues accompanied by hydrogen sulfide (H2S) production in one step. The synergistic effect of released BetP and generated H2S guaranteed chronological modulation of the immunosuppressive tumor microenvironment (ITME) to amplify the therapeutic effect of αPD-L1 for the growth, metastasis, and recurrence of tumors. This study highlighted the exceptional prospect of HA-gNCs as a self-assistance platform for cancer drug delivery.
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Antineoplásicos , Sulfuro de Hidrógeno , Nanopartículas , Neoplasias , Humanos , Sulfuro de Hidrógeno/uso terapéutico , Antineoplásicos/uso terapéutico , Sistemas de Liberación de Medicamentos/métodos , Neoplasias/tratamiento farmacológico , Neoplasias/patología , Glutatión , Inmunoterapia , Microambiente Tumoral , Línea Celular Tumoral , Nanopartículas/químicaRESUMEN
Rechargeable aqueous zinc ion batteries with abundant resources and high safety have gained extensive attention in energy storage technology. However, the cycle stability is largely limited by notorious Zn dendrite growth and water-induced interfacial side reactions. Here, a uniform and robust protection layer consisting of metal antimony (Sb) nanoparticles and micrometer-size sheets Zn4(OH)6SO4·5H2O (ZHS) is purposely designed to stabilize Zn anode via an in situ chemical reaction strategy. The two-phase protection layers (Sb/ZHS) induce a reinforcement effect on the Zn anode (Zn@Sb/ZHS). Specifically, Sb nanoparticles play the part of nucleation sites to facilitate uniform Zn plating and homogenize the electric field around the Zn surface. ZHS micrometer-size sheets possess sufficient electrolyte wettability, fast ion transfer kinetics, and anti-corrosion, thus guaranteeing uniform ion flux and inhibiting H2O decomposition. As expected, the symmetric Zn@Sb/ZHS//Zn@Sb/ZHS cells achieve a minimal voltage hysteresis and a reversible cycle of over 2000 h at 1 mA cm-2. By pairing with the MnO2 cathode, the full cell exhibits a significantly improved stability (â¼94.17 % initial capacity after 1500 cycles). This study provides a new strategy to design artificial protection layers.
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We study the explosive percolation with k-mer random sequential adsorption (RSA) process. We consider both the Achlioptas process (AP) and the inverse Achlioptas process (IAP), in which giant cluster formation is prohibited and accelerated, respectively. By employing finite-size scaling analysis, we confirm that the percolation transitions are continuous, and thus we calculate the percolation threshold and critical exponents. This allows us to determine the universality class of the k-mer explosive percolation transition. Interestingly, the numerical simulation suggests that the universality class of the explosive percolation transition with the AP alters when the k-mer size changes. In contrast, the universality class of the transition with the IAP is independent of k, but it differs from that of the RSA without the IAP.
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Surface plasmon polaritons (SPPs) on the graphene metasurfaces (GSPs) are crucial to develop a series of novel functional devices that can merge the well-established plasmonics and novel nanomaterials. Dispersion theory on GSPs is an important aspect, which can provide a basic understanding of propagating waves and further guidance for potential applications based on graphene metamaterials. In this paper, the dispersion theory and its modal characteristics of GSPs on double-layer graphene metasurfaces consisting of the same upper and lower graphene micro-ribbon arrays deposited on the dielectric medium are presented. In order to obtain its dispersion expressions of GSP mode on the structure, an analytical approach is provided by directly solving the Maxwell's equations in each region and then applying periodical conductivity boundary onto the double interfaces. The obtained dispersion expressions show that GSPs split into two newly symmetric and antisymmetric modes compared to that on the single graphene metasurface. Further, the resultant dispersion relation and its propagating properties as a function of some important physical parameters, such as spacer, ribbon width, and substrate, are treated and investigated in the Terahertz band, signifying great potentials in constructing various novel graphene-based plasmonic devices, such as deeply sub-wavelength waveguides, lenses, sensors, emitters, etc.
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Computational imaging makes it possible to reconstruct hidden objects through random media and around corners, which is of fundamental importance in various fields. Despite recent advances, computational imaging has not been studied in certain types of random scenarios, such as tortuous corridors filled with random media. We refer to this category of complex environment as a 'random corridor', and propose a reduced spatial- and ensemble-speckle intensity correlation (RSESIC) method to image a moving object obscured by a random corridor. Experimental results show that the method can reconstruct the image of a centimeter-sized hidden object with a sub-millimeter resolution by a low-cost digital camera. The imaging capability depends on three system parameters and can be characterized by the correlation fidelity (CF). Furthermore, the RSESIC method is able to recover the image of objects even for a single pixel containing the contribution of about 102 speckle grains, which overcomes the theoretical limitation of traditional speckle imaging methods. Last but not least, when the power attenuation of speckle intensity leads to serious deterioration of CF, the image of hidden objects can still be reconstructed by the corrected intensity correlation.
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The bound states in the continuum (BICs) have been investigated by simulating the optical reflectivity of a tri-layer photonic crystal slab. We found that optical BICs can occur in a class of photonic crystal systems with [Formula: see text], [Formula: see text] or [Formula: see text] rotational symmetries, which are constructed by three identical photonic crystal slabs. By applying the two mode coupled model, we obtain the reflectivity formula to fit the numerical data and evaluate the lifetime of radiation decay. In vicinity of BIC, the lifetime diverges as a power law form, when approaching the BIC point. The infinity life time of [Formula: see text] in the tri-layer structure indicate that it is a true BIC. The [Formula: see text] occurs robustly in tri-layer structures, but the resonance frequency of the BICs is dependent on the permittivity of slab, air-hole size and hole shape.
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BACKGROUND: Blood-brain barrier (BBB) disruption and ensuing immune activation are central to the pathogenesis of central nervous system (CNS) inflammatory diseases. However, the influence of BBB permeability on the clinical signs and prognosis of newly diagnosed neuromyelitis optica spectrum disorder (NMOSD) has not been examined. We investigate the relationships between BBB permeability as showed by the albumin quotient (qalb) and clinical features of NMOSD. METHODS: Demographic and clinical data of 46 patients, including peripheral blood (PB) measures (serum albumin concentration and total leukocyte, neutrophil, total lymphocyte, CD4+ T cell, and CD8+ T cell counts, complement C3 and C4 concentrations, AQP4-IgG titer),autoimmune antibody titers (ANA/SSA/SSB/Ro-52), and cerebrospinal fluid (CSF) parameters (total leukocyte count, total protein and albumin concentrations, AQP4-IgG titer), were compared between qalb(BBB permeability) increased and normal groups. Complete measures were not obtained from 9 patients, but all other measures were included in the analysis. RESULTS: According to the calculated qalb, 15 patients with albumin quotient (qalb) > (4 + age/15) × 10-3 were assigned to the qalb increased (high BBB permeability) group (33%) and the remainder to the qalb normal group. Compared to the qalb normal group, the qalb increased group exhibited significantly lower serum albumin (P=0.001) and CD4+ T cell count (P=0.044), CD8+ T cell count (P=0.014), and total T lymphocyte count (P=0.016). The qalb increased group proved higher CSF albumin, total protein, leukocyte count, and IgG titer (all P=0.000). Optic neuritis and optic nerve abnormalities on magnetic resonance images were also more frequent in the qalb increased group (P=0.037 and 0.038, respectively). Patients in the qalb increased group showed significantly poorer treatment response as indicated by the lower post-treatment change in Expanded Disability Status Scale (EDSS) score compared to the qalb normal group. CONCLUSIONS: BBB permeability is strongly associated with the clinical features and treatment response of newly diagnosed NMOSD. The qalb is a potentially valuable indicator of disease severity and an index to guide personalized treatment.
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Barrera Hematoencefálica/metabolismo , Inflamación/metabolismo , Neuromielitis Óptica/metabolismo , Índice de Severidad de la Enfermedad , Adolescente , Adulto , Anciano , Anticonvulsivantes/uso terapéutico , Estudios de Casos y Controles , Estudios de Cohortes , Femenino , Humanos , Masculino , Persona de Mediana Edad , Neuromielitis Óptica/sangre , Neuromielitis Óptica/líquido cefalorraquídeo , Neuromielitis Óptica/tratamiento farmacológico , Permeabilidad , Pronóstico , Adulto JovenRESUMEN
An ultrathin tunable absorber for the ultrahigh frequency (UHF) band is presented in this paper. The absorber is a single-layer structure based on the topology of a Salisbury screen, in which the conventional resistive layer is replaced by an active frequency-selective surface (AFSS) loaded with resistors and varactors. The reflectivity response of the absorber can be controlled by adjusting the reverse bias voltage for the varactors, which is verified by both simulated and measured results. The experimental results show that the reflectivity response of the absorber can be modulated below -10 dB over a frequency band ranging from 415 to 822 MHz. The total thickness of the absorber, 10 mm, is equivalent to only λ/72 of the lower limit frequency. The absorbing mechanism for the designed absorber is illustrated by simulating the volume loss density distributions. A detailed analysis is also carried out on the basis of these parameters, such as the AFSS shape, resistor, thickness of the foam, thickness and permittivity of the dielectric substrate, and incident angles, which contribute to the reflectivity of the AFSS absorber.
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We have theoretically investigated the reflectivity spectrums of single- and double-layer photonic crystal slabs and the dielectric multilayer stack. It is shown that light can be perfectly confined in a single-layer photonic crystal slab at a given incident angle by changing the thickness, permittivity or hole radius of the structure. With a tunable double-layer photonic crystal slab, we demonstrate that the occurrence of tunable bound states in the continuum is dependent on the spacing between two slabs. Moreover, by analytically investigating the Drude lossless multilayer stack model, the spacing dependence of bound states in the continuum is characterized as the phase matching condition that illuminates these states can occur at any nonzero incident angles by adjusting the spacing.
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We experimentally investigate a discharging flux of granular particles through a sieve plate subject to vertical vibrations. The mean mass flux shows a non-monotonic relation with the vibration strength. High-speed photography reveals that two stages, the free flight of the particles' bulk over the plate and the adhesion of the particles' bulk with the plate, alternately appear, where only the adhesion stage contributes to the flow. With two independent methods, we then measure the adhesion time under different vibration conditions, and define an adhesion flux. The adhesion flux monotonically increases with increasing vibration strength. By rescaling the adhesion flux, we find that the adhesion flux is approximately determined by the peak vibration velocity of the shaker. The conclusion is examined with other sieve geometries.
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Periodic segregation behaviors in fine mixtures of copper and alumina particles, including both percolation and eruption stages, are experimentally investigated by varying the ambient air pressure and vibrational acceleration. For the cases with moderate air pressure, the heaping profile of the granular bed keeps symmetrical in the whole periodic segregation. The symmetrical shape of the upper surface of the granular bed in the eruption stage, which resembles a miniature volcanic eruption, could be described by the Mogi model that illuminates the genuine volcanic eruption in the geography. When the air pressure increases, an asymmetrical heaping profile is observed in the eruption stage of periodic segregation. With using the image processing technique, we estimate a relative height difference between the copper and the alumina particles as the order parameter to quantitatively characterize the evolution of periodic segregation. Both eruption and percolation time, extracted from the order parameter, are plotted as a function of the vibration strength. Finally, we briefly discuss the air effect on the granular segregation behaviors.
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We experimentally investigate segregation behaviors of binary granular mixtures consisting of granular chains and spherical grains with different interstitial media under vertical vibrations. A quantitative criterion is proposed to locate the boundaries between different vibrating phases. The water-immersed granular mixture exhibits two interesting types of segregation behaviors: chain-on-top and sandwich patterns. However, the phenomenon of sandwich segregation is absent for the air-immersed mixture. The topological differences of phase diagrams between two different environments indicate that the interstitial fluid plays an important role on the granular demixing. Additionally, the phase behaviors of mixtures for the different chain lengths show a not significant discrepancy. Finally, the vibrating thickness ratio determining the phase boundary characterizes the mixing extent of the granular bed. The estimated ratios for various chain lengths exhibit a monotonically decreasing dependence, when the vibration frequency increases.
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Using finite-size scaling, we have investigated the percolation phase transitions of evolving random networks under a generalized Achlioptas process (GAP). During this GAP, the edge with a minimum product of two connecting cluster sizes is taken with a probability p from two randomly chosen edges. This model becomes the Erdös-Rényi network at p=0.5 and the random network under the Achlioptas process at p=1. Using both the fixed point of the size ratio s{2}/s{1} and the straight line of lns{1}, where s{1} and s{2} are the reduced sizes of the largest and the second-largest cluster, we demonstrate that the phase transitions of this model are continuous for 0.5 ≤ p ≤ 1. From the slopes of lns{1} and ln(s{2}/s{1})' at the critical point, we get critical exponents ß and ν of the phase transitions. At 0.5 ≤ p ≤ 0.8, it is found that ß, ν, and s{2}/s{1} at critical point are unchanged and the phase transitions belong to the same universality class. When p ≥ 0.9, ß, ν, and s{2}/s{1} at critical point vary with p and the universality class of phase transitions depends on p.