1.
J Org Chem
; 89(13): 9298-9302, 2024 Jul 05.
Artículo
en Inglés
| MEDLINE
| ID: mdl-38877984
RESUMEN
A silver-catalyzed protocol for the intermolecular radical umpolung cross-coupling protocol of silyl enol ethers with activated methylene compounds is disclosed. The protocol exhibits excellent functional group tolerance, enabling the expedient preparation of a variety of tricarbonyl compounds. Preliminary mechanistic investigations suggest that the reaction proceeds through a process involving free radicals in which silver oxide has a dual role, acting as both a catalyst and a base.