Influence of neuropeptides on the processes of higher nervous activity in primates. The action of cyclic analogs of enkephalins on the behavior of the lower monkeys.

The effect of two cyclic enkephalin analogs (IVS-43 and IVS-46) on the group and individual behavior of rhesus macaques and hamadryas baboons has been studied. A pronounced influence of IVS-46 on competitive and operant goal-directed behavior of the monkeys was identified.

[The comparative action of relanium and oxytocin on higher nervous activity in lower monkeys]. / Sravnitel'noe deistvie relaniuma i oksitotsina na vysshuiu nervnuiu deiatel'nost' nizshikh obez'ian.

Effects of relanium and oxytocin on higher nervous activity was studied in four rhesus monkeys (Macaca mulatta) and two baboons (Papio hamadryas). During observation of the animals in enclosure tranquilizing effect was seen only after relanium administration. Under the same conditions oxytocin practically did not change the general behaviour pattern of monkeys. However, steady behavioural transformations were observed under the conditions of competitive food-procuring behaviour and during the operant goal-directed reaction. Decreasing aggressiveness of dominants oxytocin in contrast to relanium had no negative effect upon their general motor activity and sensory perception. Differences in effects of the tranquilizer and the peptide were seen also at the unit activity level of the neurons. The first drug lowered the unit activity level and the degree of the functional connections in neuronal populations in a number of cortical structures. Administration of the second one led to selective shifts of the unit activity mainly in the frontal cortex of the monkeys.

[The effect of neuropeptides on the processes of higher nervous activity in primates. The action of cyclic analogs of enkephalins on the behavior of lower monkeys]. / Vliianie neiropeptidov na protsessy vysshei nervnoi deiatel'nosti u primatov. Deistvie tsiklicheskikh analogov énkefalinov na povedenie nizshikh obez'ian.

The influence of 2 cyclic enkephaline analogues (IVS-43 and IVS-46) on group and individual behaviour of rhesus and baboon monkeys was studied. The effect of IVS-46 on competitive and operant goal-directed behaviour of the monkeys was expressed. Possible mechanisms of functional reorganization of the higher nervous activity of primates under the influence of neuropeptides are discussed.

[Behavioral effects of thyroliberin on animals of various species]. / Povedencheskie éffekty tireoliberina u zhivotnykh raznykh vidov.

It has been shown that there are some significant differences in behavioural effects of exogenous thyroliberin for different mammals (mice, rats, dogs, monkeys). The necessity of a careful preclinical trial of peptide drugs is discussed.