Effects of prefrontal cortex damage on emotion understanding: EEG and behavioural evidence.

Humans are highly social beings that interact with each other on a daily basis. In these complex interactions, we get along by being able to identify others' actions and infer their intentions, thoughts and feelings. One of the major theories accounting for this critical ability assumes that the understanding of social signals is based on a primordial tendency to simulate observed actions by activating a mirror neuron system. If mirror neuron regions are important for action and emotion recognition, damage to regions in this network should lead to deficits in these domains. In the current behavioural and EEG study, we focused on the lateral prefrontal cortex including dorsal and ventral prefrontal cortex and utilized a series of task paradigms, each measuring a different aspect of recognizing others' actions or emotions from body cues. We examined 17 patients with lesions including (n = 8) or not including (n = 9) the inferior frontal gyrus, a core mirror neuron system region, and compared their performance to matched healthy control subjects (n = 18), in behavioural tasks and in an EEG observation-execution task measuring mu suppression. Our results provide support for the role of the lateral prefrontal cortex in understanding others' emotions, by showing that even unilateral lesions result in deficits in both accuracy and reaction time in tasks involving the recognition of others' emotions. In tasks involving the recognition of actions, patients showed a general increase in reaction time, but not a reduction in accuracy. Deficits in emotion recognition can be seen by either direct damage to the inferior frontal gyrus, or via damage to dorsal lateral prefrontal cortex regions, resulting in deteriorated performance and less EEG mu suppression over sensorimotor cortex.

Brightness perception changes related to pupil size.

Dilating the pupils allow more quanta of light to impact the retina. Consequently, if one pupil is dilated with a pharmacological agent (Tropicamide), the brightness of a surface under observation should increase proportionally to the pupil dilation. Little is known about causal effects of changes in pupil size on perception of an object's brightness. In a psychophysical procedure of brightness adjustment and matching, we presented to one eye geometrical patterns with a central square (the reference pattern) that differed in physical brightness within backgrounds of constant luminance. Subsequently, with the other eye, participants (n = 30) adjusted to the same luminance a similar pattern (target) whose central square luminance was randomly set higher or lower in brightness than the reference. As only one eye was treated with Tropicamide, we assessed whether the subjective brightness of the target square shifted in a consistent direction when viewed with the dilated pupil compared to the untreated (control) eye. We found that, as the pupil increased post drug administration, so significantly did the sense of brightness of the pattern (i.e., higher brightness adjustments followed viewing the reference pattern with the treated (Tropicamide) eye). A reversed effect was observed when the control eye viewed the reference pattern first. The results confirm that even slight pupil dilations can result in an enhanced perceptual experience of brightness of the attended object, corresponding to an average increase of 2.09 cd/m2 for each 1 mm increase in pupil diameter.

The "face race lightness illusion": An effect of the eyes and pupils?

In an internet-based, forced-choice, test of the 'face race lightness illusion', the majority of respondents, regardless of their ethnicity, reported perceiving the African face as darker in skin tone than the European face, despite the mean luminance, contrast and numbers of pixels of the images were identical. In the laboratory, using eye tracking, it was found that eye fixations were distributed differently on the African face and European face, so that gaze dwelled relatively longer onto the locally brighter regions of the African face and, in turn, mean pupil diameters were smaller than for the European face. There was no relationship between pupils' size and implicit social attitude (IAT) scores. In another experiment, the faces were presented either tachistoscopically (140 ms) or longer (2500 ms) so that, when gaze was prevented from looking directly at the faces in the former condition, the tendency to report the African face as "dark" disappeared, but it was present when gaze was free to move for just a few seconds. We conclude that the presence of the illusion depends on oculomotor behavior and we also propose a novel account based on a predictive strategy of sensory acquisition. Specifically, by differentially directing gaze towards to facial regions that are locally different in luminance, the resulting changes in retinal illuminance yield respectively darker or brighter percepts while attending to each face, hence minimizing the mismatch between visual input and the learned perceptual prototypes of ethnic categories.