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1.
Kardiologiia ; 42(2): 39-44, 2002.
Artículo en Ruso | MEDLINE | ID: mdl-12494206

RESUMEN

Effect of 9-12 month treatment with captopril on dopplerographic parameters of intrarenal blood flow and renal function was studied in 30 hypertensive diabetics without clinical signs of nephroangiopathy. There was an interrelationship between strict blood pressure (BP) control (average 24-hour BP below 135/83) and improvement of parameters of intrarenal hemodynamics. BP normalization and most pronounced positive changes of renal perfusion during therapy with captopril were achieved in patients with mild hypertension and initially high intrarenal resistance yet at the stage of normo- or microalbuminuria. In moderate hypertension with microalbuminuria treatment with captopril was associated with stabilization of parameters of renal blood flow and rate of 24-hour albumin excretion at their initial level despite less strict control of BP and unsatisfactory compensation of diabetes. BP response to captopril in patients with hypertension and diabetes was related to initial state of intrarenal hemodynamics. In patients with mild hypertension indexes of resistance of renal and intrarenal arteries could be used for prediction of sensitivity to antihypertensive action of captopril.


Asunto(s)
Inhibidores de la Enzima Convertidora de Angiotensina/uso terapéutico , Velocidad del Flujo Sanguíneo/fisiología , Captopril/uso terapéutico , Complicaciones de la Diabetes , Retinopatía Diabética/complicaciones , Hipertensión/complicaciones , Hipertensión/tratamiento farmacológico , Riñón/irrigación sanguínea , Riñón/diagnóstico por imagen , Arteria Renal/diagnóstico por imagen , Ultrasonografía Doppler , Adulto , Femenino , Humanos , Masculino , Persona de Mediana Edad , Tiempo
2.
Ter Arkh ; 70(12): 35-8, 1998.
Artículo en Ruso | MEDLINE | ID: mdl-10067248

RESUMEN

AIM: The study of efficacy of rehabilitation and clinical-instrumental characteristics of coronary failure in patients with ischemic heart disease (IHD) of high functional classes and moderate dyslipoproteinemia early (1.6 months) and late (1 and 3 years) after coronary by-pass operation. MATERIALS AND METHODS: The examination covered 119 males with IHD (mean age 51.8 +/- 6.9 years) 1.6 months and 3 years after coronary by-pass operation. Lipid spectrum of blood plasma, frequency of anginal attacks, 24-h nitroglycerin requirement, results of bicycle exercise and loading myocardial scintigraphy were assessed. The patients were divided into two groups. In 82 patients of group 1 total cholesterol ranged within 3 years after the surgery from 5.2 to 6.5 mmol/l, 37 patients of group 2 had no lipid disorders. RESULTS: Within 12 months after direct myocardial revascularization, the groups had similar clinical-instrumental characteristics. 3 years after the operation, patients of group 1 exhibited a rise in anginal attacks frequency, nitroglycerin requirement, size of unstable perfusion defects by 84.6, 88.8 and 26.4%, respectively. Exercise tolerance diminished by 18.7%. CONCLUSION: Moderate defects in lipid metabolism influence progression of coronary failure. This becomes especially pronounced within 3 years after coronary by-pass operation.


Asunto(s)
Puente de Arteria Coronaria , Enfermedad Coronaria/cirugía , Hiperlipoproteinemias/complicaciones , Adulto , Colesterol/sangre , Enfermedad Coronaria/diagnóstico , Enfermedad Coronaria/rehabilitación , Prueba de Esfuerzo , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Factores de Tiempo , Triglicéridos/sangre
3.
Probl Endokrinol (Mosk) ; 36(2): 77-80, 1990.
Artículo en Ruso | MEDLINE | ID: mdl-2194205

RESUMEN

The development of emotional pain stress in rats is accompanied by an increase in lipid peroxidation (LPO) products in the pancreas and a decrease in antiradical activity of its lipids. Hypoinsulinemia, of which a degree of expression is inversely proportional to an increase in peroxidation products, is observed. Antioxidant administration prevents LPO process activation in the pancreas and inhibits, to a great extent, a decrease in the level of insulin in stress. It is assumed that a certain role in the development of hypoinsulinemia in stress can be played by LPO processes resulting in the formation of active forms of oxygen and damage of the islands of Langerhans of B-cells.


Asunto(s)
Insulina/deficiencia , Peroxidación de Lípido , Dolor/metabolismo , Estrés Psicológico/metabolismo , Animales , Antioxidantes/farmacología , Hidroxitolueno Butilado/farmacología , Insulina/sangre , Anticuerpos Insulínicos/sangre , Peroxidación de Lípido/efectos de los fármacos , Peróxidos Lipídicos/análisis , Peróxidos Lipídicos/metabolismo , Masculino , Malondialdehído/análisis , Malondialdehído/metabolismo , Páncreas/análisis , Páncreas/efectos de los fármacos , Páncreas/metabolismo , Ratas
4.
Probl Endokrinol (Mosk) ; 40(3): 39-41, 1994.
Artículo en Ruso | MEDLINE | ID: mdl-8073002

RESUMEN

Rates of basal and glucose-stimulated insulin and glutathione secretion were studied in experiments with isolated rat pancreas, as were prooxidant effects on these values. The rate of oxidized and recovered glutathione release was found increased at glucose concentration increase to 16.7 mmoles in perfusion solution. Addition of prooxidants (tert-butyl hydroperoxide and Fe2+) in concentrations 10(-4) mole did not change basal insulin secretion but resulted in reduction of glucose-stimulated hormone release. Under such conditions a reduction of the rate of oxidized and recovered glutathione release by the pancreas was observed which was adequate to changed GSH/GSSG ratio in isolated Langerhans' islets. It may be supposed that lipid peroxidation results in changed thiol-disulfide ratio in Langerhans' islets B cells and in reduction of their sensitivity to secretogen effect.


Asunto(s)
Glutatión/metabolismo , Insulina/metabolismo , Peroxidación de Lípido/efectos de los fármacos , Oxidantes/farmacología , Páncreas/metabolismo , Animales , Metabolismo Basal , Compuestos Ferrosos/farmacología , Glucosa/farmacología , Técnicas In Vitro , Secreción de Insulina , Masculino , Perfusión , Peróxidos/farmacología , Ratas , Ratas Wistar , terc-Butilhidroperóxido
5.
Biull Eksp Biol Med ; 116(8): 165-7, 1993 Aug.
Artículo en Ruso | MEDLINE | ID: mdl-8274692

RESUMEN

The effect of pro-oxidants (tert-butyl peroxide and FeSO4) on rats perfusing isolated pancreas insulin secretion was studied. Pro-oxidants (10(-4) M) preperfusion during 20 minutes did not change significantly the basal insulin secretion and decreased glucose-stimulated secretion of the one. The content of pancreas TBA-active products increased twice after pro-oxidants effect and ratio of reduced and oxidized glutathiones liberation rates decreased from 2 to 0.5. The disturbance of hormone secretion as a result of decrease of Langerhans islets B-cells reduced glutathione pool is suppose to be one of the mechanisms of hypoinsulinemia development at host's states characterizing with lipids peroxidation activation.


Asunto(s)
Insulina/metabolismo , Islotes Pancreáticos/efectos de los fármacos , Islotes Pancreáticos/metabolismo , Especies Reactivas de Oxígeno/farmacología , Animales , Compuestos Ferrosos/farmacología , Técnicas In Vitro , Secreción de Insulina , Peroxidación de Lípido/efectos de los fármacos , Masculino , Oxidantes/farmacología , Perfusión/métodos , Peróxidos/farmacología , Ratas , Ratas Wistar , Factores de Tiempo , terc-Butilhidroperóxido
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