Confined In-Situ Encapsulation of Co/C Composites with Increased Heterogeneous Interface Polarization for Enhanced Electromagnetic Performance.

It is an urgent problem to realize reliable microwave absorption materials (MAMs) with low density. To address this issue, a series of controlled experiments w ere carried out, which indicated that the tubular structure enables excellent microwave absorption properties with a lower powder filling rate. This performance is attributable to the combined dielectric and magnetic loss mechanisms provided by Co/C and the interface polarization facilitated by multiple heterogeneous interfaces. Particularly, Co@C nanotubes, benefiting from the enhanced heterointerface polarization due to their abundant specific surface area and the reduced electron migration barrier induced by their 1D stacked structure, effectively achieved a dual enhancement of dielectric loss and polarization loss at lower powder filling ratios. Furthermore, the magnetic coupling effect of magnetic nanoparticle arrays in tubular structures is demonstrated by micromagnetic simulation, which have been few reported elsewhere. These propertied enable Co@C nanotubes to achieve minimum reflection loss and maximum effective absorption broadband values of 61.0 dB and 5.5 GHz, respectively, with a powder filling ratio of 20 wt% and a thickness of 1.94 mm. This study reveals the significance of designing 1D structures in reducing powder filling ratio and matching thickness, providing valuable insights for developing MAMs with different microstructures.

Alterations in gut and genital microbiota associated with gynecological diseases: a systematic review and meta-analysis.

BACKGROUND: Increasing number of studies have demonstrated certain patterns of microbial changes in gynecological diseases; however, the interaction between them remains unclear. To evaluate the consistency or specificity across multiple studies on different gynecological diseases and microbial alterations at different sites of the body (gut and genital tract), we conducted a systematic review and meta-analysis. METHODS: We searched PubMed, Embase, Web of Science, and Cochrane Library up to December 5, 2022(PROSPERO: CRD42023400205). Eligible studies focused on gynecological diseases in adult women, applied next-generation sequencing on microbiome, and reported outcomes including alpha or beta diversity or relative abundance. The random-effects model on standardized mean difference (SMD) was conducted using the inverse-variance method for alpha diversity indices. RESULTS: Of 3327 unique articles, 87 eligible studies were included. Significant decreases were found in gut microbiome of patients versus controls (observed species SMD=-0.35; 95%CI, -0.62 to -0.09; Shannon index SMD=-0.23; 95%CI, -0.40 to -0.06), whereas significant increases were observed in vaginal microbiome (Chao1 SMD = 1.15; 95%CI, 0.74 to 1.56; Shannon index SMD = 0.51; 95%CI, 0.16 to 0.86). Most studies of different diagnostic categories showed no significant differences in beta diversity. Disease specificity was observed, but almost all the changes were only replicated in three studies, except for the increased Aerococcus in bacterial vaginosis (BV). Patients with major gynecological diseases shared the enrichment of Prevotella and depletion of Lactobacillus, and an overlap in microbes was implied between BV, cervical intraepithelial neoplasia, and cervical cancer. CONCLUSIONS: These findings demonstrated an association between alterations in gut and genital microbiota and gynecological diseases. The most observed results were shared alterations across diseases rather than disease-specific alterations. Therefore, further investigation is required to identify specific biomarkers for diagnosis and treatment in the future.

Reactivities of silane coupling agents in the silica/rubber composites: Theoretical insights into the relationships between energy barriers and electronic characteristics.

Si69 and Si75, typical commodities of silane coupling agents, are often employed in tire recipes to work as the bridges connecting silica and polymers, with which rolling resistance and wet traction are enhanced without loss in abrasion resistance. In this article, the reactivities of Si69 and Si75 with silica and various rubbers were theoretically investigated by using density functional theory (DFT). When the agents were coupled with silica, not only the acid+water condition but also the pure acid condition was confirmed to readily trigger the condensation reactions. The corresponding Gibbs free energy barriers were related to the charge distributions of reaction regions. As the agents suffered from the homolysis of central SS bonds, the generated single-S-tailer radicals (RS·) showed significantly higher reactivities of both the radical addition and the α-H transfer reactions with rubbers, due to the stronger radical philicities of the terminal sulfur radicals with larger condensed local softnesses [s0 (S)]. When the agents underwent the heterolysis of central SS bonds, the terminal sulfur anions with smaller s- (S) indices, however, facilitated the nucleophilic addition reactions with rubbers. Several derivative indices based on the condensed local softnesses were also proposed here to shed light on the reactivities from the viewpoint of the relationship between energy barriers and electronic characteristics. The above findings pave the way for the design of new kinds of silane coupling agents using computer-aided techniques, and meanwhile, provide references for the practical application of Si69 and Si75 to the silica/rubbers systems.

Indirect regulation of HIPPO pathway by miRNA mediates high-intensity intermittent exercise to ameliorate aging skeletal muscle function.

Exercise-induced microRNA (miRNA) and HIPPO pathways participate in the regulation of skeletal muscle plasticity but their underlying mechanisms remain unclear. We aimed to investigate the effect of high-intensity interval training (HIIT) on miRNA expression and the HIPPO pathway in the skeletal muscle of aging rats to determine its role in the amelioration of muscle aging. Thirty-six 18-month-old female rats were randomly divided into sedentary control (SED, n = 12), moderate-intensity continuous training (MICT, n = 12), and HIIT (n = 12) groups, with continuous exercise for 8 months. Quantitative reverse transcription-polymerase chain reaction, immunoblotting, KEGG enrichment, and dual-luciferase assays were performed on the target skeletal muscle. Compared with the SED group, the MICT and HIIT groups showed a significant trend of improvement in Lee's index and grip strength and a marked increase in skeletal muscle mitochondrial function, apoptosis, antioxidant, and lipolysis-related protein expression. They also exhibited PI3K/AKT pathway activation and a decrease in expression of HIPPO pathway-related proteins; 20 miRNAs were differentially expressed and enriched in the exercise group compared with the SED group, including the HIPPO pathway and metabolic pathways. Further analysis of L6 cells confirmed that miR-182 may target PTEN, which indirectly regulates HIPPO signaling, but not Mob1. the combined application of HIIT and MICT increased the antioxidant and lipolytic capacities of skeletal muscle and improved atrophy of aging skeletal muscle; HIIT was more effective than MICT. This may be related to HIIT-mediated AKT pathway activation and HIPPO pathway inhibition by miRNAs (miR-486 and miR-182).

A New Assistance Navigation Method for Substation Inspection Robots to Safely Cross Grass Areas.

With the development of intelligent substations, inspection robots are widely used to ensure the safe and stable operation of substations. Due to the prevalence of grass around the substation in the external environment, the inspection robot will be affected by grass when performing the inspection task, which can easily lead to the interruption of the inspection task. At present, inspection robots based on LiDAR sensors regard grass as hard obstacles such as stones, resulting in interruption of inspection tasks and decreased inspection efficiency. Moreover, there are inaccurate multiple object-detection boxes in grass recognition. To address these issues, this paper proposes a new assistance navigation method for substation inspection robots to cross grass areas safely. First, an assistant navigation algorithm is designed to enable the substation inspection robot to recognize grass and to cross the grass obstacles on the route of movement to continue the inspection work. Second, a three-layer convolutional structure of the Faster-RCNN network in the assistant navigation algorithm is improved instead of the original full connection structure for optimizing the object-detection boxes. Finally, compared with several Faster-RCNN networks with different convolutional kernel dimensions, the experimental results show that at the convolutional kernel dimension of 1024, the proposed method in this paper improves the mAP by 4.13% and the mAP is 91.25% at IoU threshold 0.5 in the range of IoU thresholds from 0.5 to 0.9 with respect to the basic network. In addition, the assistant navigation algorithm designed in this paper fuses the ultrasonic radar signals with the object recognition results and then performs the safety judgment to make the inspection robot safely cross the grass area, which improves the inspection efficiency.

A Small Object Detection Method for Oil Leakage Defects in Substations Based on Improved Faster-RCNN.

Since substations are key parts of power transmission, ensuring the safety of substations involves monitoring whether the substation equipment is in a normal state. Oil leakage detection is one of the necessary daily tasks of substation inspection robots, which can immediately find out whether there is oil leakage in the equipment in operation so as to ensure the service life of the equipment and maintain the safe and stable operation of the system. At present, there are still some challenges in oil leakage detection in substation equipment: there is a lack of a more accurate method of detecting oil leakage in small objects, and there is no combination of intelligent inspection robots to assist substation inspection workers in judging oil leakage accidents. To address these issues, this paper proposes a small object detection method for oil leakage defects in substations. This paper proposes a small object detection method for oil leakage defects in substations, which is based on the feature extraction network Resnet-101 of the Faster-RCNN model for improvement. In order to decrease the loss of information in the original image, especially for small objects, this method is developed by canceling the downsampling operation and replacing the large convolutional kernel with a small convolutional kernel. In addition, the method proposed in this paper is combined with an intelligent inspection robot, and an oil leakage decision-making scheme is designed, which can provide substation equipment oil leakage maintenance recommendations for substation workers to deal with oil leakage accidents. Finally, the experimental validation of real substation oil leakage image collection is carried out by the intelligent inspection robot equipped with a camera. The experimental results show that the proposed FRRNet101-c model in this paper has the best performance for oil leakage detection in substation equipment compared with several baseline models, improving the Mean Average Precision (mAP) by 6.3%, especially in detecting small objects, which has improved by 12%.

Twist2 Reduced NLRP3-Induced Inflammation of Infantile Pneumonia via Regulation of Mitochondrial Permeability Transition by FOXO1.

BACKGROUND: Infantile pneumonia is an acute inflammatory lesion of the lung caused by mycoplasma pneumonia. Indeed, Twist2 signaling pathway controls inflammatory reaction, oxidative stress, and other biological reaction. However, the regulation of Twist2 on the inflammation in infantile pneumonia remains unclear. This study explained that the function and mechanism of Twist2 in infantile pneumonia. METHODS: The subjects included the serum samples of 12 patients with infantile pneumonia and normal healthy volunteers from Hunan Children's Hospital. Besides, mice were given with lipopolysaccharide (LPS) into the lung. Moreover, RAW264.7 macrophages were stimulated with LPS for 4 h and added to the culture medium. RESULTS: In present study, in serum of patients with infantile pneumonia or lung tissue of mice model with infantile pneumonia, TWIST2 expression was lessened. Apart from that, TWIST2 protein could reduce the inflammatory reaction in mice model with infantile pneumonia, resulting in an inhibition in lung injury. Conversely, over-expression of TWIST2 also decreased inflammatory reaction in macrophages model via the regulation of FOXO1/NLRP3 pathway. Downregulation of TWIST2 promoted the inflammation in macrophages model by the regulation of FOXO1/NLRP3 pathway. CONCLUSION: According to the findings, present study have identified that the TWIST2 could reduce the inflammation of infantile pneumonia by NLRP3 inflammasome through the regulation of mitochondrial permeability transition and the induction of FOXO1 expression.

Alterations in mitochondrial biogenesis and respiratory activity, inflammation of the senescence-associated secretory phenotype, and lipolysis in the perirenal fat and liver of rats following lifelong exercise and detraining.

The primary aims of this study were to determine the effects of lifelong exercise and detraining on age-related alterations in mitochondrial function, inflammation associated with senescence-associated secretory phenotype (SASP), and lipolysis in the perirenal fat and liver of rats. Female Sprague-Dawley rats were randomly assigned to four groups: young control (n = 12), old control (n = 12), detraining (n = 12), and lifelong exercise (n = 12). We then investigated mitochondrial function, SASP-associated inflammation, and lipolysis in the perirenal fat and liver using qRT-PCR and western blotting to assess the expression of AKT, hypoxia-inducible factor 1α (HIF-1α), nuclear factor-kappa B (NF-κB), c-jun kinase (JNK), and p38 mitogen-activated protein kinase (p38MAPK). In the tissues of both the perirenal fat and liver, lifelong exercise significantly improved mitochondrial function, SASP-associated inflammation, and lipolysis. Meanwhile, pathways associated with inflammatory regulation were inhibited, predominantly via the activation of phosphorylated-AKT (p-AKT) and suppression of HIF-1α in both tissues, and via JNK in the perirenal fat and p38MAPK in the liver. Furthermore, detraining activated NF-κB expression in both tissues and induced the upregulation of serum high-sensitivity C-reactive protein (hsCRP) levels. Collectively, lifelong exercise was found to exert beneficial effects by ameliorating age-related alterations in mitochondrial function, SASP-associated inflammation, and lipolysis in perirenal fat and liver tissues, potentially inhibiting inflammation via the JNK and p38 MAPK pathways, respectively, as well as the HIF-1α and AKT pathways in both tissues. In contrast, detraining induced high levels of circulating hsCRP by activating the NF-κB signaling pathway in both tissues.

Probabilistic Hierarchical Quantum Information Splitting of Arbitrary Multi-Qubit States.

By utilizing the non-maximally entangled four-qubit cluster states as the quantum channel, we first propose a hierarchical quantum information splitting scheme of arbitrary three-qubit states among three agents with a certain probability. Then we generalize the scheme to arbitrary multi-qubit states. Hierarchy is reflected on the different abilities of agents to restore the target state. The high-grade agent only needs the help of one low-grade agent, while the low-grade agent requires all the other agents' assistance. The designated receiver performs positive operator-valued measurement (POVM) which is elaborately constructed with the aid of Hadamard matrix. It is worth mentioning that a general expression of recovery operation is derived to disclose the relationship with measurement outcomes. Moreover, the scheme is extended to multiple agents by means of the symmetry of cluster states.

Tunable Size Dependence of Quantum Plasmon of Charged Gold Nanoparticles.

The quantum behavior of surface plasmons has received extensive attention, benefiting from the development of exquisite nanotechnology and the diverse applications. Blueshift, redshift, and nonshift of localized surface plasmon resonances (LSPRs) have all been reported as the particle size decreases and enters the quantum size regime, but the underlying physical mechanism to induce these controversial size dependences is not clear. Herein, we propose an improved semiclassical model for modifying the dielectric function of metal nanospheres by combining the intrinsic quantized electron transitions and surface electron injection or extraction to investigate the plasmon shift and LSPR size dependence of the charged Au nanoparticles. We experimentally observe that the nonmonotonic blueshift of LSPRs with size for Au nanoparticles is turned into an approximately monotonic blueshift by increasing the electron donor concentration in the reduction solution, and it can also be transformed to an approximately monotonic redshift after surface passivation by ligand molecules. Moreover, we demonstrate controlled blueshift and redshift for the electron and hole plasmons in Cu_{2-x}S@Au core-shell nanoparticles by injecting electrons. The experimental observations and the theoretical calculations clarify the controversial size dependences of LSPR reported in the literature, reveal the critical role of surface electron injection or extraction in the transformation between the different size dependences of LSPRs, and are helpful for understanding the nature of surface plasmons in the quantum size regime.

Design and analysis of refractive index sensors based on slotted photonic crystal nanobeam cavities with sidewall gratings.

We propose and numerically investigate a refractive index sensor based on a one-dimensional slotted photonic crystal nanobeam cavity with sidewall gratings for refractive index sensing in a gaseous environment. By using the three-dimensional finite-difference time-domain method, we demonstrate that our proposed sensor simultaneously possesses a high quality factor of $ 3.71 \times {10^6} $3.71×106 and a high sensitivity of 508 nm/RIU (refractive index unit) at the resonant wavelength near 1583 nm, yielding a detection limit as low as $ 1.97 \times {10^{ - 6}} $1.97×10-6 RIU. Moreover, the mode volume of the cavity's fundamental resonant mode is found to be as small as $ 0.022(\lambda /n)^3 $0.022(λ/n)3, resulting in a very compact effective sensing area. We finally study and assess the effect of fabrication disorder on the performances of our proposed sensor. We believe our proposed sensor will be a promising candidate for applications not only in multiplexed biochemical sensing and multielement mixture detection, but also in optical trapping of single biomolecules or nanoparticles.

Long noncoding RNA SOX2-OT facilitates laryngeal squamous cell carcinoma development by epigenetically inhibiting PTEN via methyltransferase EZH2.

Long noncoding RNAs (lncRNAs) play important roles in the initiation and progression of various cancers, including laryngeal squamous cell carcinoma (LSCC). Recently, lncRNA Sox2 overlapping transcript (SOX2-OT) has been identified as an oncogene in various cancers. However, the functional role and the regulatory mechanism of SOX2-OT in LSCC remains unclear. In this study, we found that SOX2-OT expression was increased and negatively correlated with PTEN expression in LSCC tissues. Furthermore, SOX2-OT overexpression promoted LSCC cell proliferation, migration, invasion, and suppressed cell apoptosis in vitro, as well as facilitated the in vivo tumorigenicity. By contrast, SOX2-OT silencing exerted the opposite effect. Mechanically, SOX2-OT interacted with EZH2 and recruited EZH2 to induce H3K27me3 and epigenetically inhibited PTEN expression in LSCC cells. Additionally, EZH2 silencing and PTEN overexpression significantly abrogated the SOX2-OT overexpression-mediated promotion of LSCC cell malignant behavior. Collectively, our findings demonstrate that SOX2-OT inhibits PTEN expression to facilitate LSCC development through EZH2-mediated H3K27me3. © 2019 IUBMB Life, 71(9):1230-1239, 2019.

Topological phase transition and highly tunable topological transport in topological crystalline insulator Pb1-x Sn x Te (111) thin films.

We report the magneotransport studies on the topological crystalline insulator (TCI) Pb1-x Sn x Te (111) single crystal thin films grown by molecular beam epitaxy. By decreasing Sn content, an enhanced sheet resistance and decreased hole density are observed in Pb1-x Sn x Te (111) thin films. A weak antilocalization likely related to the topological surface states is observed in transport of Pb1-x Sn x Te (x > 0.4) thin films, whereas a weak localization is displayed in Pb1-x Sn x Te (x < 0.4) thin films. This tunable weak antilocalization to weak localization transition is attributed to the open of Dirac gap because of the topological phase transition in TCI Pb1-x Sn x Te. Our research has a potential application in the tunable electronic and spintronic devices and is very significant to the fundamental research based on TCI Pb1-x Sn x Te thin film.

Pure magnetic-quadrupole scattering and efficient second-harmonic generation from plasmon-dielectric hybrid nano-antennas.

We theoretically demonstrate that pure magnetic quadrupole (MQ) scattering is achieved via the excitation of anapole modes and Fano resonance in noble metal (Au or Ag) and high refractive index dielectric (AlGaAs) hybrid nano-antennas. In Au-AlGaAs hybrid nano-antennas, electric anapole and magnetic anapole modes are observed, leading to the suppressions of electric and magnetic dipoles. Introducing gain material to AlGaAs nanodisk to increase the strength of electric quadrupole (EQ) Fano resonance leads to the suppression of EQ scattering. Then, ideal MQ scattering is achieved at the wavelength of total scattering cross-section dip. The increase of signal-to-noise ratio of MQ results in the great enhancement of near-field inside AlGaAs nanodisk. Additionally, the strong MQ resonance exhibits great capability for boosting second-harmonic generation by proper mode matching. These findings achieved in subwavelength geometries have important implications for functional metamaterials and nonlinear photonic nanodevices.

Adjacent segment motion following multi-level ACDF: a kinematic and clinical study in patients with zero-profile anchored spacer or plate.

PURPOSE: To investigate the adjacent segment kinematics, including the instantaneous axis of rotation (IAR) and range of motion (ROM), after anterior cervical discectomy and fusion (ACDF), and to compare between ACDF with zero-profile anchored spacer (ACDF-Z) and ACDF with plate (ACDF-P). METHODS: Eighty-seven patients (ACDF-Z = 63; ACDF-P = 24) were included. Flexion, extension and neutral cervical radiographs were obtained before operation and at 1-year follow-up. C2-C7 ROM, adjacent segment ROMs, and IARs were measured. Clinical evaluation was based on the Visual Analogue Scale, Neck Disability Index, and Japanese Orthopaedic Association score. RESULTS: After ACDF-Z, location of the superior IAR-AP reduced 1.60 mm, which represents 8% of the vertebral body (P < 0.001), and location of the inferior IAR-SI reduced 2.19 mm, 17% of the vertebral body (P = 0.02). After ACDF-P, location of the superior IAR-AP increased 0.8 mm, which means 6% of the vertebral body (P = 0.008), location of the inferior IAR-AP increased 3.34 mm, 22% of the vertebral body (P = 0.03), and location of the inferior IAR-SI reduced 3.14 mm, 25% of the vertebral body (P = 0.002). C2-C7 ROM significantly decreased after both ACDF-Z and ACDF-P (P < 0.001). Neither ACDF-Z nor ACDF-P significantly affected the adjacent segment ROMs (P > 0.05). CONCLUSIONS: Both ACDF-Z and ACDF-P significantly impacted cervical kinematics, although both procedures obtained satisfactory clinical results in the treatment of cervical spondylosis. After both ACDF-Z and ACDF-P, C2-C7 ROM decreased significantly, while adjacent segment ROMs were preserved. ACDF-Z and ACDF-P impact the location of adjacent segment IAR-SI in similar way, while impact the location of adjacent segment IAR-AP in diverse ways. These slides can be retrieved under Electronic Supplementary Material.

Non-Drude Magneto-Transport Behavior in a Topological Crystalline Insulator/Band Insulator Heterostructure.

The Drude model is one of the most fundamental models used to understand the electronic carrier transport in materials, including recently discovered topological materials. Here, we present a magneto-transport study revealing the non-Drude transport behavior in a heterostructure of topological crystalline insulator (TCI) SnTe and band insulator PbTe which exhibits a nonsaturating linear magneto-resistance (MR) effect, a novel phenomenon widely observed in topological materials with gapless dispersion. It is shown that in the van der Pauw geometry in which the longitudinal and transverse magneto-resistances are measured to extract the magneto-conductivity, the two-band Drude model is not sufficient to self-consistently describe both the longitudinal and transverse magneto-conductivities. Furthermore, in the Corbino geometry, which directly measures the longitudinal magneto-conductivity σ xx( B) for a straightforward comparison with the Drude model, the MR, 1/σ xx( B), still reveals a large linear MR effect, in direct discrepancy with the Drude model. While shining further light on the multiple-carrier transport in TCI, this study highlights an unusual magneto-transport character of topological materials that challenges the standard Drude picture of electron transport.

Upregulation of CX3CL1 mediated by NF-κB activation in dorsal root ganglion contributes to peripheral sensitization and chronic pain induced by oxaliplatin administration.

Painful peripheral neuropathy is a severe side effect in oxaliplatin therapy that compromises cancer patients' quality of life. However, its underlying pathogenic mechanisms remain largely unknown. Here, we found that intraperitoneal consecutive administration of oxaliplatin significantly increased excitability of small diameter dorsal root ganglion neurons and induced thermal hyperalgesia in rats. Furthermore, the CX3CL1 expression was significantly increased after oxaliplatin treatment, and intrathecal injection of a neutralizing antibody against CX3CL1 markedly attenuated the enhanced excitability of dorsal root ganglion neurons and thermal hyperalgesia. Importantly, the upregulated CX3CL1 is mediated by the NF-κB signaling pathway, as inhibition of NF-κB p65 activation with pyrrolidine dithiocarbamate or p65 siRNA inhibited the upregulation of CX3CL1, the enhanced excitability of dorsal root ganglion neurons, and thermal hyperalgesia induced by oxaliplatin. Further studies with chromatin immunoprecipitation found that oxaliplatin treatment increased the recruitment of NF-κB p65 to the CX3Cl1 promoter region. Our results suggest that upregulation of CX3CL1 in dorsal root ganglion mediated by NF-κB activation contributes to the peripheral sensitization and chronic pain induced by oxaliplatin administration.

LDH-A promotes malignant progression via activation of epithelial-to-mesenchymal transition and conferring stemness in muscle-invasive bladder cancer.

Lactate dehydrogenase-A(LDH-A) is an important rate-limiting enzyme in the Warburg effect. Survival analysis indicated poor clinical outcomes in MIBC with high LDH-A expression. The results of in vitro experiment indicated that LDH-A promotes MIBC cells proliferation, invasion and migration. The positive relationship between LDH-A expression and CSC/EMT markers was confirmed both in invasive bladder cell line and in 136 MIBC specimens. Thus, we conclude that LDH-A may be a promising target for MIBC.

An ultra-compact mechanical antenna based on PTFE highly charged electret for extremely low frequency communications.

-Extremely-Low Frequencies (ELF, 30∼300Hz) transmitting antennas in wireless communications are often limited by antenna size and complex impedance matching networks. In this paper, we propose an ultra-small Artificial Electret Type Mechanical Antenna (AETMA), which is composed of a single charge electret and a driving structure, with high radiation efficiency and small size. In order to improve the electric dipole moment of the mechanical antenna, we employ a pin-plate corona polarization technique and a unidirectional stretching treatment to obtain a porous thin-film electret that can stably store a large amount of charge. Its surface charge density can reach 5.355 mC/m2 and we analyze its surface potential stability. To assess the radiation capability of AETMA, the radiation field models of three kinds of mechanical antennas are established and verified by simulation. Additionally, we simulate and compare the planar electret and curved electret configurations to determine the optimal form of AETMA. The radiation intensity of the planar electret is found to be superior under the same moment of inertia. Finally, a 1m-scale artificial electret antenna is designed based on the optimal model. Comparative analysis with existing rotary mechanical antenna schemes confirms the great potential of the proposed AETMA for portable, miniaturized and high-performance wireless communication devices.

Effectiveness and economic evaluation of rhTPO and rhIL-11 in the treatment of cancer therapy induced thrombocytopenia based on real-world research.

Objective: Based on real-world research, we aimed to evaluate the effectiveness and economy of recombinant human thrombopoietin (rhTPO) and recombinant human interleukin 11 (rhIL-11) in the treatment of cancer therapy induced thrombocytopenia (CTIT). Methods: We retrospectively collected clinical data of patients with CTIT who were treated with rhTPO or rhIL-11 in a single cancer hospital from January 2020 to December 2021. Propensity score matching (PSM) was applied to eliminate confounding factors. The measurements of effectiveness analysis were the platelet compliance rate, days of medication, days of compliance, highest platelet count after medication, platelet count elevation before and after medication, and the lowest platelet count after next-cycle cancer therapy. The economic evaluation was performed according to the results of the effectiveness evaluation. At the same time, patients were stratified according to type of tumor and grade of thrombocytopenia for subgroup analysis. Results: A total of 262 patients were collected and 174 patients were enrolled after PSM, 87 in the rhTPO group and 87 in the rhIL-11 group. In all patients, there were no significant differences in the platelet compliance rate, mean days of medication, median days of compliance, median highest platelet count after medication, and the median platelet count elevation before and after medication between the two groups (p > 0.05), but the median lowest platelet count after next-cycle cancer therapy in the rhTPO group was lower than that in the rhIL-11 group (p = 0.014). The subgroup analysis showed that the rhTPO group had longer mean days of medication than the rhIL-11 group in patients with hematological malignancies (p = 0.042), and a lower median lowest platelet count after next-cycle cancer therapy in patients with grade I/II thrombocytopenia than rhIL-11 group (p = 0.022), with no significant difference in other outcome indicators (p > 0.05). As there was no statistically significant difference in platelet compliance rate between the two groups, the cost-minimization analysis showed that the rhIL-11 group had lower treatment costs than the rhTPO group. Conclusion: RhTPO and rhIL-11 showed similar effectiveness in the treatment of CTIT, but rhIL-11 was more advantageous in economic cost.