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Eur J Clin Microbiol Infect Dis ; 43(4): 777-784, 2024 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-38277033

RESUMEN

The combination of ceftazidime-avibactam (CAZ-AVI) and aztreonam (ATM) is used to treat MBL-producing Enterobacterales-related infections. The new combination aztreonam-avibactam (AZA) is currently in development. We compared results obtained with the new MIC test strip (MTS) AZA (Liofilchem) with broth microdilution method (BMD) on 41 MBL-producing Enterobacterales from 41 clinical samples. The MTS AZA was also compared to combination testing method using CAZ-AVI and ATM strips. Compared to BMD, categorical agreement (CA) was 100%. Compared with combination testing method, CA was 97.6%. The MTS AZA can be used to determine MICs levels of AZA or CAZ-AVI/ATM combinations.


Asunto(s)
Antibacterianos , Compuestos de Azabiciclo , Aztreonam , Humanos , Aztreonam/farmacología , Antibacterianos/farmacología , Antibacterianos/uso terapéutico , Ceftazidima/uso terapéutico , beta-Lactamasas , Combinación de Medicamentos , Pruebas de Sensibilidad Microbiana
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