Calculation of the liquor system pliability using the mathematical simulation method.

Liquor circulation is a directed flow of the liquor from sites of its secretion to sites of resorption. This slow flow is modulated by pulsation caused by heart work. Phase-contrast magnetic resonance imaging is a method for noninvasive measurements of the linear velocity of these pulses in the cerebral aqueduct. A mathematical model reproducing pulsed flow of the liquor in the cerebral aqueduct is proposed and the procedure of evaluation of these parameters is presented. The pliability liquor system can be calculated from the values of liquor flow linear velocity in the cerebral aqueduct, measured by noninvasive method.

[Immunobiologically active compounds from skin].

This paper describes physiochemical and biological properties of 3 immunologically active compounds extracted by acetone from porcine skin. High pressure gel chromatography confirmed their heterogeneity. RP-HPLC of compound 2 (C2 or K-activin) also characterizes it as a heterogeneous entity. It was shown to inhibit proliferation of cultured fibroblasts from human fetuses and exhibit weak activity in general anaphylactic reaction (anaphylactic shock) and skin anaphylactic reaction. A summary of data on immunologically active compounds are presented with special emphasis laid on acetone-extractable K-activin.

[[Elimination of toxins from the body using electrochemical oxidation]. / Udalenie toksinov iz organizma s pomoshch'iu élektrokhimicheskogo okisleniia.

Potentialities of electrochemical procedures were considered in simulation of liver monooxygenases functions directed to clearance of blood and tissues from toxic and ballast substances by means of hydroxylating oxidation. Electrooxidation of specific endogenous toxin bilirubin, catalyzed by platinum electrode, was studied in model physiological solutions, blood, lymph and blood plasma. Three problems developed during direct electrooxidation of toxins in blood: efficiency of electrochemical cell, "protein protection" of the toxin, compatibility of electrochemical cell and blood. Influences of electrochemical oxidation on various patterns of intact animal homeostasis were studied as well as efficiency of the oxidation in a body was shown. Artificial detoxicating system was elaborated for clinical purpose using these experimental data.

[Indirect electrochemical oxidation using active oxygen carriers in a model of detoxicating function of the liver]. / Nepriamoe élektrokhimicheskoe okislenie s ispol'zovaniem perenoschikov aktivnogo kisloroda v modeli detoksitsiruiushchei funktsii pecheni.

As development of the electrochemical model of liver tissue monooxygenase system met with a serious problem of compatibility between electrochemical unit and blood, a procedure of indirect electrochemical oxidation of blood was proposed where carriers of active oxygen were used. Blood did not contact with the electrochemical system and electrolysis occurred in solution of oxygen carrier (0.89% NaCl), which accumulated active oxygen in the form of sodium hypochlorite. Sodium hypochlorite, administered into patients, enabled to bypass "the effect of protein protection" of toxic metabolites; it simulated both liver tissue monooxygenase functions and phagocytosis molecular mechanisms.

[Sodium hypochlorite in the detoxification therapy of postresuscitation states]. / Gipokhlorit natriia v detoksikatsionnoi terapii postreanimatsionnykh sostoianii.

The experiments on dogs recovered after a 10-min clinical death of acute blood loss have shown possible effective use of 300-500 mg/l sodium hypochlorite solution at a dose of 7-10 ml/kg for detoxication in the early postresuscitation period. A significant reduction in the level of toxemia within 3 hours of postresuscitation period, as compared to the control, promotes an increase in the percent of the animals survived and a more complete recovery of the neurological status. It has been shown in vitro than detoxication of lymph in septic patients was more effective using electrochemical oxidation, as compared to sorption on a carbon CKH sorbent, with lymph protein loss being significantly less. The technique of electrochemical liquid oxidation can be recommended as an alternative detoxicating technique in critical conditions.

[Sodium hypochlorite in the treatment of suppurative wounds]. / Gipokhlorit natriia v lechenii gnoinykh ran.

Under observation there were 174 patients with purulent wounds, 54 of them were treated with application of 0.06% solution of sodium hypochlorite, and 20 patients made up a control group and were treated by traditional methods. It was found that the application of the solution of sodium hypochlorite results in sharp elevation of susceptibility of wound microflora to antibiotics and facilitates more rapid debridement of the wounds and makes the treatment at the hospital 3.7 and 2.4 times shorter correspondingly (as compared with the control group).

Some pharmacological properties of immunotropic preparation from porcine skin.

We studied pharmacological properties of immunotropic preparation from porcine skin (skin resorption effect and acute and chronic toxicity). It was demonstrated that the preparation did not damage the skin during evaluation of skin-resorption effect; evaluation of acute and chronic toxicity revealed no changes in the general state of experimental animals and histological structure of visceral organs and skin; evaluation of chronic toxicity showed that the preparation induced no changes in blood biochemical parameters compared to the control.

New aspects of technical testing of intravascular stents.

Maximum magnetic resonance artifacts from stents are often determined by the presence of ferromagnetic compounds in the delivery system. We propose a mathematic model describing artifacts caused by nitinol stents. A method for evaluation of critical radial rigidity of the stents was developed.