RESUMEN
Therapeutic options are limited in cases of autosomal recessive congenital ichthyosis with inadequate response to topical agents. Acitretin is the current standard of care in these patients, but its use is limited by cumulative toxicity when prolonged therapy is needed in children. There is evidence to suggest that high doses of vitamin D can normalize keratinization and suppress inflammatory cytokines. Here, we report a patient with lamellar ichthyosis with a novel mutation in the Nipa-like Domain-Containing 4 (NIPAL4) gene. High dose short-term vitamin D therapy was administered with a dramatic and sustained clinical response.
Asunto(s)
Ictiosis Lamelar , Neoplasias Cutáneas , Niño , Humanos , Ictiosis Lamelar/tratamiento farmacológico , Ictiosis Lamelar/genética , Vitamina D/uso terapéutico , Acitretina/uso terapéuticoAsunto(s)
Hamartoma , Nevo , Anomalías Cutáneas , Neoplasias Cutáneas , Lactante , Humanos , Neoplasias Cutáneas/diagnósticoAsunto(s)
Dermoscopía , Quiste Epidérmico/patología , Enfermedades de la Piel/patología , Adulto , Femenino , HumanosRESUMEN
The clinician's quest for time-saving and technique-insensitive technology has led to the development of simplified self-etch adhesives that are predominantly water or solvent based. Several studies have shown that conventional air-drying procedures are incapable of eliminating all the residual water in the adhesive and that it may even cause collapse of the underlying collagen matrix. We hypothesized that heat from a light source may be effective in removing water from these adhesives. The aim of this study was, therefore, to evaluate the effectiveness of heat vs conventional air drying in eliminating water droplets from self-etch adhesive. A self-etch adhesive was applied to bur-cut dentin surfaces, which were then allotted to one of two treatment procedures for eliminating residual water from the adhesive: conventional air drying or the experimental heat application. Specimens were then prepared and analyzed using SEM. Specimens in the experimental group showed no evidence of water treeing within the adhesive layer. Thus, it was concluded that heat radiation was an effective method to remove residual water from simplified adhesives.