RESUMEN
The term Big Data has come to encompass a number of concepts and uses within medicine. This paper lays out the relevance and application of large collections of data in the radiation oncology community. We describe the potential importance and uses in clinical practice. The important concepts are then described and how they have been or could be implemented are discussed. Impediments to progress in the collection and use of sufficient quantities of data are also described. Finally, recommendations for how the community can move forward to achieve the potential of big data in radiation oncology are provided.
Asunto(s)
Bases de Datos Factuales , Informática Médica/métodos , Neoplasias/terapia , Oncología por Radiación/estadística & datos numéricos , Minería de Datos , Humanos , Almacenamiento y Recuperación de la Información , Motivación , Estadificación de Neoplasias , Neoplasias/diagnóstico , Neoplasias/patologíaRESUMEN
An in situ immunoassay technique is described which is sensitive to specific binding to surface immobile antigen or antibody. The phenomena of surface plasmon oscillations are shown to be sensitive to antigen-antibody binding on a substrate. An advantage of the technique is that no molecular labeling is required. The technique allows the detection of the presence of approximately 6 X 10(8) molecules on the approximately 1 mm2 area of detection (approximately 1.5 X 10(-8) g/cm2). An elementary apparatus is described which allows the kinetics of the antigen-antibody binding to be accurately recorded in real time. A detailed example is presented. A second version of the apparatus of similar accuracy with improved temporal resolution is described.
Asunto(s)
Reacciones Antígeno-Anticuerpo , Técnicas de Inmunoadsorción/instrumentación , Adsorción , Cinética , Plata , Propiedades de SuperficieRESUMEN
A method is presented for checking the treatment time calculation for high dose rate (HDR) vaginal cylinder treatments. The method represents an independent check of the HDR planning system and can take into account nonuniform isodose line coverage around the cylinder. Only the air kerma strength of the source and information that is available from the written directive are required. The maximum discrepancy for a representative set of cylinder plans done on a Nucletron unit was 5%. A working HTML JavaScript program is included in the Appendix.