A wise person plants a tree a day before the end of the world: coping with the emotional experience of climate change in Poland.

It is now widely accepted that we are in a climate emergency, and the number of people who are concerned about this problem is growing. Yet, qualitative, in-depth studies to investigate the emotional response to climate change were conducted either in high-income, western countries, or in low-income countries particularly vulnerable to climate change. To our knowledge, there are no qualitative studies conducted in countries that share great barriers to decarbonization while being significant contributors to carbon emissions. Since climate change affects people globally, it is crucial to study this topic in a variety of socio-political contexts. In this work, we discuss views and reflections voiced by highly concerned residents of Poland, a Central European country that is a major contributor to Europe's carbon emissions. We conducted 40 semi-structured interviews with Polish residents, who self-identified as concerned about climate change. A variety of emotions related to climate change were identified and placed in the context of four major themes: dangers posed by climate change, the inevitability of its consequences, attributions of responsibility, and commonality of concern. Our findings highlight a variety of often ambivalent and conflicting emotions that change along with the participant's thoughts, experiences and behaviours. Furthermore, we describe a wide repertoire of coping strategies, which promoted well-being and sustained long-term engagement in climate action. As such, our work contributes to research on a broad array of climate-related emotions. Supplementary Information: The online version contains supplementary material available at 10.1007/s12144-022-03807-3.

Defects in transcription coupled repair interfere with expression of p90(MDM2) in response to ultraviolet light.

Ultraviolet (UV) irradiation transiently stabilizes p53 through a mechanism that may require a decrease in the activity of the ubiquitin ligase, p90(MDM2). Conversely, the recovery of low levels of p53 following UV exposure may depend on an increase in p90(MDM2). The level of p90(MDM2) is increased by UV light following the p53-dependent induction of an internal mdm2 promoter, P2. If this induction of mdm2 were critical for the recovery of low levels of p53 following UV exposure, defects in mdm2's transcription would result in a prolonged increase in p53. Cells defective in transcription coupled repair (TCR) maintain high levels of p53 for a prolonged period following UV exposure. Such cells also have defects in general transcription after UV irradiation. We investigated whether TCR-deficient cells express diminished levels of mdm2 mRNA and p90(MDM2) following UV exposure. We found that transcription of mdm2 was reduced in TCR-deficient cells. The uninducible mdm2 promoter, P1, was more sensitive to the inhibitory effects of UV irradiation than the P2 promoter. The decrease in transcription from the P1 promoter was sufficient to reduce the level of p90(MDM2) and correlated with a prolonged increase in p53. Thus, p53-independent transcription of mdm2 appears critical to p53's regulation.

Chemiluminescence determination of thioridazine hydrochloride by flow-injection analysis.

Hydrogen peroxide, potassium permanganate, potassium dichromate, potassium hexacyanoferrate(III), cerium(IV) sulphate and sodium peroxidisulphate have been tested as potential reagents for chemiluminescence generation from the oxidation of phenothiazine derivatives. Only with potassium permanganate in acidic medium were satisfying results achieved. A total of 13 different phenothiazine derivatives produce luminescence of different intensities on oxidation. Thioridazine hydrochloride was chosen to develop a rapid and simple method for its determination in pharmaceutical formulations. The limit of detection is 1.2 x 10(-6) mol l(-1), and 110 samples per hour can be determined.

Early postnatal surge of serum Clara cell secretory protein in newborn infants.

BACKGROUND: Clara cell secretory protein (CCSP) is an anti-inflammatory mediator, but its role in neonatal lung adaptation and diseases is uncertain. OBJECTIVE: To characterize postnatal changes in serum CCSP in relation to gestation, respiratory disease (RDS) and bronchopulmonary dysplasia (BPD) in comparison with other anti-inflammatory cytokines (IL-4, -10 and -13). METHODS: Blood was collected from 76 infants (26 of 23-29 weeks' gestation, 33 of 30-36 weeks' gestation and 17 term infants) at birth (preterm cord blood); on admission; at 12, 24 and 48 h; and on days 3-4 and 7 of life. CCSP was assayed by ELISA and cytokines by Bio-Plex. RESULTS: Median serum CCSP in extremely and moderately preterm infants rose from a baseline of 13.6 and 15.9 to 33.4 ng/ml (p = 0.04) and 59.8 ng/ml (p = 0.03) at 12 h of age, respectively. CCSP levels were highest in term infants (80.7 ng/ml at 12 h). CCSP then decreased to 22.5 ng/ml on days 3-4 (p = 0.001). CCSP of 37 RDS infants fell to a lower baseline on days 4 and 7 than that of the 22 non-RDS preterms. The 8 infants who developed BPD had persistently low serum CCSP (12.7 ng/ml at 12 h). In contrast, early postnatal changes were not seen in IL-4, -10 and -13 levels, but low IL-10 and -13 levels were found on day 7 in BPD infants. CONCLUSIONS: Serum CCSP levels were characterized by an early postnatal surge. This apparent gestation-influenced surge may represent an initiation of a protective cascade against postnatal lung injury during extrauterine adaptation.

Mechanical properties of C/C composites processed by wet impregnation and P-CVI methods.

Wet impregnation with phenolic resin and P-CVI methods were used to manufacture C/C composites. The influence of impregnation process of porous 2D carbon fibre substrate with resin and pyrocarbon deposited by CVD technique on mechanical properties of formed composites was studied. The results indicate that using P-CVI method large pores remain in the matrix resulting in lower mechanical strength. This fraction does not undergo any changes during thermal treatment. The flexural modulus of C/C composites depends mainly on the type of reinforcing fibres. The values of moduli measured in composites obtained by both methods do not differ significantly. Comparison of two methods of fabrication of C/C composite show that much better strengths can be achieved by forming the carbon matrix in solid state.