1.
Tetrahedron Lett
; 882022 Jan 05.
Artículo
en Inglés
| MEDLINE
| ID: mdl-35719215
RESUMEN
Nitriles are important organic functional groups, allowing for installation of nitrogen in organic synthesis. The Pinner reaction transforms nitriles into esters via the imidate group, but in general has previously necessitated harsh acid conditions. This work builds on the utility of the Pinner reaction through a stereoselective desymmetrization of dinitriles to form γ- and δ-lactones in good yields and diastereoselectivites.