RESUMEN
Prostate carcinoma is the most common non-dermatological malignancy in men and only second to lung cancer as the leading cause of cancer related deaths in America. Moreover, metastasis to the skin is even more uncommon following apparently successful treatment of a preexisting prostate cancer. We present an 87-year-old man previously diagnosed with prostate cancer treated with brachytherapy, who presented with a metastatic prostate adenocarcinoma of the scalp mimicking a basal cell carcinoma. Herein, we present a patient with an NKX 3.1 positive cutaneous metastatic prostate carcinoma identified through NKX3.1 stain rather than the typical PSA/PSAP stain.
Asunto(s)
Adenocarcinoma/metabolismo , Neoplasias de Cabeza y Cuello/metabolismo , Proteínas de Homeodominio/metabolismo , Neoplasias de la Próstata/metabolismo , Cuero Cabelludo , Neoplasias Cutáneas/metabolismo , Factores de Transcripción/metabolismo , Adenocarcinoma/diagnóstico , Adenocarcinoma/radioterapia , Adenocarcinoma/secundario , Anciano de 80 o más Años , Braquiterapia , Carcinoma Basocelular/diagnóstico , Diagnóstico Diferencial , Neoplasias de Cabeza y Cuello/diagnóstico , Neoplasias de Cabeza y Cuello/secundario , Humanos , Masculino , Neoplasias de la Próstata/diagnóstico , Neoplasias de la Próstata/patología , Neoplasias de la Próstata/radioterapia , Neoplasias Cutáneas/diagnóstico , Neoplasias Cutáneas/secundarioRESUMEN
Subacute radiodermatitis is a rare cutaneous disease induced by ionizing radiation. It often is mistaken for contact dermatitis, fixed drug eruption, or connective-tissue disease. Routine use of fluoroscopy has flourished in many types of medical procedures. We present a case of subacute radiodermatitis stemming from prolonged fluoroscopic exposure during angiography; the lesion appeared only at the site of contact for the ground plate, remote from the field of radiation.
Asunto(s)
Enfermedades del Tejido Conjuntivo/diagnóstico , Dermatitis por Contacto/diagnóstico , Erupciones por Medicamentos/diagnóstico , Radiodermatitis/patología , Piel/patología , Biopsia , Diagnóstico Diferencial , Humanos , Masculino , Persona de Mediana Edad , Radiodermatitis/diagnósticoRESUMEN
We hereby report a case of a reticulated acanthoma with sebaceous differentiation (RASD), a rare and often mislabeled benign lesion that is characterized by epidermal acanthosis and clusters of sebocytes in a reticulated seborrheic keratosis-like pattern. The presence of multiple sebaceous tumors, most notably cystic sebaceous adenomas and keratoacanthomas, has been associated with Muir-Torre syndrome (MTS). Although very rare, cases of RASD have been reported with MTS, which potentially offers profound clinical significance to this neoplasm. This case further supports the lack of association of MTS with RASD.
Asunto(s)
Acantoma/patología , Síndrome de Muir-Torre , Glándulas Sebáceas/patología , Neoplasias Cutáneas/patología , Anciano de 80 o más Años , Biopsia , Diferenciación Celular , Humanos , MasculinoRESUMEN
Hansen disease, also known as leprosy, is a chronic granulomatous infectious disease that is caused by Mycobacterium leprae. We report an unusual case of a 65-year-old man who presented with multiple anesthetic, annular, erythematous, scaly plaques with a raised border without any known exposures to leprosy. Histologic examination revealed a perineural lymphohistiocytic infiltrate and rare bacilli demonstrated on Fite staining. After confirmation with polymerase chain reaction (PCR) and consultation with the National Hansen's Disease Program (Baton Rouge, Louisiana), the patient was placed on a regimen of rifampicin 600 mg once monthly and dapsone 100 mg once daily for 6 months, which showed considerable improvement. This case demonstrates the identification of leprosy in central Florida, a region that is not known to be endemic to the disease. Leprosy, however rare, must be part of a practitioner's differential diagnosis even without history of traditional exposures.