Early and Successful Combination Antiretroviral Therapy Normalizes Survival Time in Patients Coinfected With Human Immunodeficiency Virus and Human T-cell Lymphotrophic Virus Type 1.

BACKGROUND: Coinfection with human T-cell lymphotrophic virus type 1 (HTLV-1) is associated with shorter survival for adults and children infected with human immunodeficiency virus (HIV), although the reasons remain a matter of debate. We evaluated the factors associated with survival time in a large cohort of HIV/HTLV-1-coinfected and HIV-monoinfected individuals on combination antiretroviral therapy (cART). METHODS: In a nested, retrospective case-control study (1:1), we reviewed medical records of people with HIV infection on cART in a referral AIDS center in Salvador, Brazil. We matched 149 patients coinfected with HTLV-1 (cases) by age at HIV diagnosis and sex, to an equal number of HTLV-uninfected persons (controls). Death rates, survival time, baseline and current CD4 cell count, last HIV-1 RNA plasma viral load (pVL), and causes of death were compared between groups. RESULTS: The overall mortality rate was 2.1 person-years (76 deaths, 53 among coinfected patients). Survival time for cases (16.7 ± 0.7 years) was significantly shorter than for controls (18.1 ± 0.4 years; P = .001). Among patients with pVL >50 copies/mL, coinfected patients had a shorter survival time (8.4 ± 0.8 years) than monoinfected ones (12.9 ± 1.4 years; P = .02), regardless of pVL magnitude. However, survival time did not differ for HIV-monoinfected (19.0 ± 0.4 years) or coinfected patients (20.2 ± 0.6 years) presenting with pVL <50 copies/mL (P = .5). Deceased coinfected patients had higher initial CD4 count (417 ± 219 cells) than monoinfected ones with the same outcome (177 ± 160 cells; P = .004), while survivors had similar CD4 cell count at baseline, regardless of HTLV status. CONCLUSIONS: Successful cART is able to normalize survival for coinfected patients and should be introduced for all coinfected patients, regardless of CD4 cell count.HIV/human T-cell lymphotrophic virus type 1 coinfection is believed to decrease survival of coinfected patients. In this case-control study, we demonstrate that successful combination antiretroviral therapy (last HIV viral load <50 copies/mL) is able to improve survival of coinfected patients to levels observed for those monoinfected.

Should Focal Nodular Hyperplasia Still be Operated Upon? Analysis of a Case Series.

BACKGROUND: Focal nodular hyperplasia (FNH) is a frequent benign liver lesion. Its course is considered benign, and there is no recommendation for its treatment. Nevertheless, the literature presents a high incidence of surgery. AIM: To evaluate the results of conservative treatment in a series of patients with presumed FNH. METHODS: The study included patients diagnosed with FNH from May 2007 to July 2017 based on conventional imaging or magnetic resonance imaging with liver-specific contrast (MRI-LSC) or lesion biopsy (histology/immunohistochemical analysis). Patients were followed clinically and using imaging exams. RESULTS: In a total of 54 patients, the diagnosis was obtained by typical findings on computed tomography scan and gadolinium MRI in 48.1% of the patients, by MRI-LSC in 31.5%, and by histological examination in 20.4% of cases. The mean follow-up time was 35.5 months. The initially asymptomatic patients remained symptom-free, and none of those with HNF-related pain had to worsen of the initial symptom. Conservative treatment was effective in 94.4% of the cases. In only 3 cases, there was a need for some therapeutic approach (5.5%); 2 cases for pain and 1 case for lesion growth during follow-up. CONCLUSION: The present study suggests that it is safe to conservatively manage patients with FNH presumed by highly accurate imaging tests. Similar to hepatic hemangiomas, surgery for FNH should be an exception.

Development of a theoretical-practical script for clinical simulation.

OBJECTIVE: To develop a theoretical-practical script based on the opinion of experts to be used in simulated clinical activities. METHOD: Qualitative study through analysis of content of interviews with experts on the theme in order to develop the proposed script. Of the 24 invited experts, 12 specialists from educational institutions in Brazil and abroad participated in the study in compliance with the ethical precepts. The experts responded to questions on the characterization of their study attributes and described the items required for the development of a simulated scenario. In view of the responses obtained, data content was analyzed and classified into units and subunits of significance. RESULTS: The items mentioned for the development of the script generated seven units of significance. The units and subunits of significance were gathered in three stages of the main components of the simulated scenario: prior, preparation, and finals. CONCLUSION: This study enables an innovative, stimulating teaching experience, making it easier for professors to use the simulation resource as a learning process in an effective and objective manner, as a guide to professors and researchers in the area of clinical simulation. OBJETIVO: Construir, com base na opinião de peritos, roteiro teórico-prático para uso em atividade clínica simulada. MÉTODO: Trata-se de um estudo qualitativo por meio de análise de conteúdo de entrevistas de peritos no assunto para construção do roteiro proposto. Seguido os preceitos éticos, entre os 24 peritos convidados pertencentes a instituições de ensino do Brasil e do exterior. Os peritos responderam a questões sobre a caracterização dos seus atributos de estudo e descreveram os itens imprescindíveis à construção de um cenário simulado. Diante das respostas obtidas, os dados foram analisados em relação ao seu conteúdo e organizados em unidades e subunidades de significância. RESULTADOS: Participaram 12 especialistas. Os itens mencionados para construção do roteiro originaram sete unidades de significância. As unidades e suas subunidades de significância foram ainda reunidas em três fases dos componentes principais do cenário simulado: prévios, preparo e finais. CONCLUSÃO: Este estudo permite um ensino inovador, estimulante e possibilita a facilidade ao professor, quanto à utilização do recurso de simulação, como processo de aprendizagem de maneira eficiente e objetiva, sendo um norteador aos docentes e pesquisadores na área de simulação clínica.

Absenteeism due to mental disorders in health professionals at a hospital in southern Brazil. / Absenteísmo por transtornos mentais em trabalhadores de saúde em um hospital no sul do Brasil.

Objective To describe the health profile of mental and behavioral disorders in health professionals at a teaching hospital in southern Brazil. Methods This was a quantitative, retrospective cross-sectional epidemiological study whose data were collected through institutional documents used to feed the Health Monitoring System for Nursing Professionals and involved all absenteeism occurred in 2011. Results We found 55 records of absenteeism due to mental and behavioral disorders, a total of 317 days absent. Nursing technicians were the most absentee, with 29.09% of the records. The intensive care unit represented the sector with the highest number of days absent, 81%, and depressive episodes were the most frequent, representing 52.72% of mental disorders. Conclusion The results showed that mental disorders in health professionals are a cause for concern and urgently need intervention.

Generalized Resistance Deficits in inmates with hypertension: missing resources that limit health.

OBJECTIVE: to understand the Generalized Resistance Deficits of people deprived of liberty with hypertension in a Brazilian prison unit. METHOD: qualitative research, anchored in Salutogenesis, carried out with 38 people with hypertension from a Brazilian prison unit, from February to July 2022, with a semi-structured interview with open-ended questions, whose analysis was thematic, explaining the limitations to health in prison. RESULTS: 13 Generalized Resistance Deficits were reported, mostly related to the prison environment and, to a lesser extent, to the social group and the individual, respectively. Living in prison for people with hypertension implies living with a high number of Generalized Resistance Deficits, accentuating the movement towards the disease pole. FINAL CONSIDERATIONS: knowing Generalized Resistance Deficits allows directing health promotion to support the use of available Generalized Resistance Resources and contributes to the expansion of intersectoral policies.

Impact of reading intervention on the phonological awareness of children with autism spectrum disorder: a systematic review and meta-analysis.

PURPOSE: To review studies that have intervention in reading with impacts on phonological awareness in children with autism spectrum disorder. RESEARCH STRATEGIES: Searches took place until February 2021 in Cochrane, Embase, ERIC (Education Resources Information Center), LILACS (Latin American and Caribbean Health Sciences Literature), PubMed/Medline, Scopus, Web of Science and gray literature databases. SELECTION CRITERIA: The review included experimental studies with preschoolers and schoolchildren with ASD. Two independent reviewers selected the studies and, in case of disagreement, a third reviewer was consulted. DATA ANALYSIS: Joanna Briggs Institute checklists were used for risk of bias. A random effects meta-analysis was performed and the certainty of the evidence was assessed using the GRADE tool. RESULTS: Eight studies with some impact on phonological awareness were reviewed. The risk of bias was low and moderate. The certainty of the evidence was low for randomized trials and very low for non-randomised trials. Comparison of pre- and post-therapy on the Preschool Literacy Test (TOPEL) showed that children with ASD improved phonological awareness, with a mean difference between baseline and post-therapy of 6.21 (95% CI = 3.75-8.67; I2 = 0%). CONCLUSION: Shared reading and software activities with words and phrases can alter phonological awareness. These results support further research with larger samples and a detailed description of the intervention to observe its effectiveness in phonological awareness.

[Description of workloads and fatigue experienced among health workers in a teaching hospital]. / Cargas e desgastes de trabalho vivenciados entre trabalhadores de saúde em um hospital de ensino.

This is an exploratory, descriptive and quantitative study, based on the following categories: work process, workloads and fatigue in a teaching hospital in Curitiba in the southern region of Brazil. The article characterizes the load and stress experienced in a university hospital, based on a previous study entitled "System for monitoring the health of nursing workers" (SIMOSTE). The results show that females were the most affected (85.9%) and the most affected professionals were nursing assistants (53.1%). The highest number of sick leaves was due to diseases of the osteoarticular system (25.2%) and the most significant loads were mechanical and physiological with 33.06% each. These results may support intervention strategies in the policies directed toward the workers' health to ensure a better quality of life and consequently improve the quality of care provided to the user.

Trait and state anxiety in healthcare professionals of intensive care unit.

OBJECTIVE: To estimate trait and state anxiety levels among intensivecare professionals during the Covid-19 pandemic. METHOD: Cross-sectional, analytical study, conducted from April to July 2022, in a teaching hospital in southern Brazil, using the State-Trait Anxiety Inventory scale. RESULTS: Trait and state anxiety were present in more than half of the sample, being associated with gender, age group, having children, weekly workload, time working in the hospital and ICU (p<0.05) for the state; and associated with gender, having children, profession, daily and weekly workload, and time working in the hospital (p<0.05) for the trait. CONCLUSION: Trait and state anxiety were medium to high level for women, young, without children, non-nurses, with a daily shift of 9 to 18 working hours, a weekly workload of more than 40 hours, with less than five years of experience in intensive care and with more than five years of experience working in the institution.

Factors associated with the SARS-CoV-2 infection among health professionals from university hospitals. / Factores asociados a la infección por SARS-CoV-2 en profesionales de la salud de hospitales universitarios.

to investigate factors associated with the SARS-CoV-2 infection among health professionals from university hospitals. a multicenter, mixed approach study with concomitant incorporated strategy, carried out with 559 professionals in the quantitative stage, and 599 in the qualitative stage. Four data collection instruments were used, applied by means of an electronic form. The quantitative analysis was performed with descriptive and inferential statistics and the qualitative data were processed by means of content analysis. the factors associated with the infection were as follows: performance of the RT-PCR test (p<0.001) and units offering care to COVID-19 patients (p=0.028). Having symptoms increased 5.63 times the prevalence of infection and adhering to social distancing most of the time in private life reduced it by 53.9%. The qualitative data evidenced difficulties faced by the professionals: scarcity and low quality of Personal Protective Equipment, work overload, physical distancing at work, inadequate processes and routines and lack of a mass screening and testing policy. the factors associated with the SARS-CoV-2 infection among health professionals were mostly related to occupational issues.

investigar los factores asociados a la infección por SARSCoV-2 en los profesionales de la salud de hospitales universitarios. estudio multicéntrico, con abordaje mixto con estrategia incorporada concomitante, realizado con 559 profesionales en la etapa cuantitativa, y 599 en la etapa cualitativa. Fueron utilizados cuatro instrumentos de recolección de datos, aplicados a través un formulario electrónico. El análisis cuantitativo se realizó mediante estadística descriptiva e inferencial y los datos cualitativos mediante análisis de contenido los factores asociados a la infección fueron: realización de la prueba "RT-PCR" (p<0,001) y unidades que atienden a pacientes con COVID-19 (p=0,028). Tener síntomas aumentó la prevalencia de infección 5,63 veces y cumplir la mayor parte del tiempo con el distanciamiento social en la vida privada la redujo un 53,9%. Los datos cualitativos mostraron las dificultades que enfrentaron los profesionales: escasez y baja calidad de equipos de protección personal, sobrecarga de trabajo, distanciamiento físico en el trabajo, procesos y rutinas inadecuados y la ausencia de una política de triage y testeo masivos. los factores asociados a la infección por SARS-CoV-2 en los profesionales de la salud se relacionaron mayormente con cuestiones laborales.

(1) Las cuestiones laborales influyeron en la protección de los profesionales durante la pandemia. (2) La alta adhesión a las precauciones estándar y al distanciamiento no disminuyeron los casos positivos. (3) La baja calidad de los EPP y las fallas en el triage dificultaron la protección en el trabajo. (4) La infraestructura hospitalaria no favoreció el distanciamiento físico entre los equipos.

investigar fatores associados à infecção por SARS-CoV-2 entre profissionais da saúde de hospitais universitários. estudo multicêntrico, de abordagem mista com estratégia incorporada concomitante, realizado com 559 profissionais na etapa quantitativa, e 599 na etapa qualitativa. Foram utilizados quatro instrumentos de coleta de dados, aplicados via formulário eletrônico. A análise quantitativa foi realizada com estatística descritiva e inferencial e os dados qualitativos por meio de análise de conteúdo. os fatores associados à infeção foram: realização de teste "RT-PCR" (p<0,001) e unidades com atendimento a pacientes com COVID-19 (p=0,028). Ter sintomas aumentou em 5,63 vezes a prevalência de infeção e aderir ao distanciamento social na maior parte do tempo na vida particular reduziu em 53,9%. Dados qualitativos evidenciaram dificuldades enfrentadas pelos profissionais: escassez e baixa qualidade de equipamentos de proteção individual, sobrecarga de trabalho, distanciamento físico no trabalho, processos e rotinas inadequadas e ausência de uma política de triagem e testagem em massa. os fatores associados à infecção por SARS-CoV-2 entre profissionais da saúde foram em sua maioria relacionados a questões ocupacionais.

[Characteristics of victims and fatal accidents at the workplace]. / Caracterização das vítimas e dos acidentes de trabalho fatais.

This is a quantitative, descriptive, retrospective documental study on fatal accidents occurred during the period from o2006 to 2010, in which workers were treated at Hospital do Trabalhador, located in Curitiba/Parand. We selected 25 notifications for the outcome death. This study aimed to characterize victims and fatal occupational accidents. Fatal occupational accidents hit workers with a mean age of 35 years (SD = 13.0694), of the male sex, n = 23 (92%). Typical occupational accidents accounted for 52% (n = 13) of cases. One of the preventive measures proposed to reduce the number of fatal occupational accidents is the performance of educational and preventive work at the workplace by nurses. Moreover, it is necessary to rethink transit violence as a relevant factor for the cause of death of workers as well.

Magnitude of the contralateral efferent olivocochlear effect as a function of the frequency.

Background: The activation of the medial olivocochlear reflex reduces the cochlear gain, which is manifested perceptually as decreased auditory sensitivity. However, it has remained unclear whether the extent of this suppression varies according to the cochlear region involved. Here we aims to assess the magnitude of contralateral efferent suppression across human cochlea, at low levels, and its impact on hearing sensitivity. Methods: Assuming that acoustic stimulation activates the contralateral medial olivocochlear reflex, we evaluated the magnitude of the suppressive effect as a function of frequency in 17 subjects with normal hearing. Absolute thresholds were measured for bursts tones of various durations (10, 100, and 500 ms) and frequencies (250, 500, 1000, 4000, and 8000 Hz) in the presence or absence of contralateral white noise at 60 dB SPL. Results: We found that contralateral noise raised the absolute threshold for the burst tones evaluated. The effect was greater at lower than higher frequencies (3.85 dB at 250 Hz vs. 2.22 dB at 8000 Hz). Conclusions: Our findings suggest that in humans, the magnitude of this suppression varies according to the cochlear region stimulated, with a greater effect towards the apex (lower frequencies) than the base (higher frequencies) of the cochlea.

Lung cancer and occupational exposure: hospital-based case-control study.

OBJECTIVE: To analyze the relationship between occupation and lung cancer in patients at a national referral hospital for cancer care in southern Brazil. METHOD: Hospital-based case-control study conducted between February and October 2019. Occupational histories were coded according to international classifications and translated into occupations associated with lung cancer (List A and B). The odds ratios were adjusted for smoking, with a 95% confidence interval, calculated by conditional logistic regression. RESULTS: 99 cases and 227 controls were included. Among men, the occupation of painters (list A) was associated with lung cancer (OR = 14.3; 95% CI: 1.8-116.5), there were no occupations in list B associated with lung cancer. In women, no increased risks were found. CONCLUSIONS: It has been shown that exposure to occupational carcinogens among repair and construction painters increases the risk of lung cancer.

Occupational characterization of workers exposed to asbestos: an integrative review.

Asbestos is a mineral fiber abundant in nature and classified as a carcinogen since 1987. The present study aimed to identify, in the scientific literature, what are the occupation and activities developed by sick workers and which categories would be affected with asbestos-related diseases. Through a literature review performed in the following databases: PubMed, CINAHL (Cumulative Index to Nursing and Allied Health Literature), Web of Science, and Regional Portal of the Virtual Health Library, 23 studies published from 2015 to 2020 were selected and evaluated. The occupations that showed greater illness due to exposure to asbestos were general asbestos workers (40%), miners (22%), and textile workers (9%), followed by naval, automotive, carpentry, doll-making, construction, and upholstery workers, as well as workers involved in the rescue, recovery, cleaning, and restoration of the World Trade Center (4%). Of the disease associated with exposure to asbestos, the most described is malignant mesothelioma (43%). Evidence found corroborate pre-existing information in the literature showing that exposure to asbestos may be harmful to health. Moreover, the importance of using personal protective equipment was emphasized, in order to prevent the development of asbestos-related diseases.

O asbesto é uma fibra mineral abundante na natureza, classificado como substância cancerígena desde 1987. Objetivou-se identificar, na literatura científica, quais são as ocupações e atividades desenvolvidas por trabalhadores adoecidos e quais categorias seriam afetadas com doenças relacionadas ao asbesto. O presente estudo trata-se de uma revisão de literatura realizada mediante a busca nas bases de dados PubMed, CINAHL (Cumulative Index to Nursing and Allied Health Literature), Web of Science e Portal Regional da Biblioteca Virtual em Saúde, sendo selecionados e avaliados 23 estudos publicados entre 2015 e 2020. As ocupações que demonstraram maior adoecimento pela exposição ao asbesto foram trabalhadores gerais de indústrias de asbesto (40%), mineradores (22%) e do setor têxtil (9%), seguidos por trabalhadores da indústria naval, do setor automotivo, carpinteiros, do setor de fabricação de bonecas, da construção civil, estofadores e trabalhadores que participaram do resgate, recuperação, limpeza e restauração do local do World Trade Center (4%). Entre as patologias associadas à exposição ao asbesto, a principal descrita é o mesotelioma maligno (43%). As evidências encontradas corroboram as informações preexistentes na literatura de que a exposição ao asbesto pode ser prejudicial à saúde. Ainda, ressalta-se a importância da utilização de equipamentos de proteção individual, a fim de evitar o desenvolvimento de doenças relacionadas ao asbesto.

Curcumin induces peripheral antinociception by opioidergic and cannabinoidergic mechanism: Pharmacological evidence.

BACKGROUND: Curcumin is one of the compounds present in plants of the genus Curcuma sp., being very used not only as condiment but also with medicinal purposes. As an analgesic, papers highlight the efficacy of curcumin in the treatment of various types of pain. AIMS: In this study we evaluated the peripheral antinociceptive effect of curcumin and by which mechanisms this effect is induced. MAIN METHODS: The mice paw pressure test was used on animals which had increased pain sensitivity by intraplantar injection of carrageenan. All the drugs were administered in the right hind paw. KEY FINDINGS: Curcumin was administered to the right hind paw animals induced antinociceptive effect. Non -selective antagonist of opioid receptors naloxone reverted the antinociceptive effect induced by curcumin. Selective antagonists for µ, δ and κ opioid receptors clocinnamox, naltrindole and nor- binaltorphimine, respectively, reverted the antinociceptive effect induced by curcumin. Bestatin, enkephalinases inhibitor that degrade peptides opioids, did not change the nociceptive response. Selective antagonists for CB1 and CB2 cannabinoid receptors, AM251 and AM630, respectively, reversed the antinociceptive effect induced by curcumin. The MAFP inhibitor of the enzyme FAAH which breaks down anandamide, JZL184, enzyme inhibitor MAGL which breaks down the 2-AG, as well as the VDM11 anandamide reuptake inhibitor potentiated the antinociceptive effect of curcumin. SIGNIFICANCE: These results suggest that curcumin possibly peripheral antinociception induced by opioid and cannabinoid systems activation and possibly for endocannabinoids and opioids release.

[A contribution to occupational health: a guide on the exposure to biological fluids]. / Uma contribuição à saúde dos trabalhadores: um guia sobre exposição aos fluídos biológicos.

Health workers are exposed to occupational hazards at the workplace, among which we highlight the biological risk. Information and orientation should be provided regarding the conduct that workers are expected to follow in the case becoming exposed. Thus, this guide is intended to provide the elements to orient workers' conduct in cases of biological exposure, improving adherence to the monitoring protocol.

Competences in the training of nurses to assist the airway of adult patients in urgency and emergency situations.

OBJECTIVE: construction and validation in appearance and content of the competence frameworks and of the Entrustable Professional Activities to develop skills in the training of nurses to assist the airway of adult patients in urgency and emergency situations. METHOD: a descriptive and methodological study developed in four phases: in the first, a workshop was held, composed of experts, for the construction of the competence frameworks; in the second, the material was validated using the Snowball Technique and the Delphi Technique, in the third, content analysis and calculation of the Content Validation Index were conducted; and in the fourth phase, the Entrustable Professional Activities were built, validated in simulated workshops. RESULTS: the competence frameworks were built and validated, with a resulting CVI≥0.85 in all the items. The Entrustable Professional Activities were validated by experts regarding their applicability; of these, 44% stated they were applicable in simulated environments, 100% that they were useful content and with appropriate language, 22% suggested the insertion of new items to assess competence, 11% reported the difficulty of assessing competence individually in the clinical settings, and 11% of the experts referred to the need for prior training of the teacher/facilitator to use it. CONCLUSION: the study resulted in the construction of competence frameworks and six Entrustable Professional Activities relating them to the domains of essential competences in the training of nurses to assist the airway of adult patients in urgency and emergency situations. The participation of experts in the construction and validation of this material was essential to guarantee the theoretical and practical relevance of the result.

Psychosocial risks and the health of health workers: reflections on Brazilian labor reform.

OBJECTIVE: to reflect on the psychosocial risks and their impacts on the health of health workers in light of the Brazilian economic context and Labor Reform. METHOD: reflective study on the Brazilian Labor Reform and its impacts on health of health workers. RESULTS: although the changes observed in the labor sphere have contributed to improvements in health and safety policies for, these changes have also contributed to the emergence of new risks arising from work activities, including psychosocial risks, which affect all occupational categories. Final considerations: we understand that the Brazilian Labor Reform carried out in 2017 leads to the weakening of labor relations, increases workers' exposure to risks in the workplace, increases the risk of illness, and opposes the global movement of international organizations aimed at the prevention of aggravation in workers' health and also at preserving their health.

Lung cancer related to occupational exposure: an integrative review.

OBJECTIVE: To identify in the literature the carcinogenic agents found in the work environment, the occupations and the risk for lung cancer. METHOD: A descriptive and analytical study of the Integrative Literature Review type was carried out in national and international databases from the last ten years in the period from 2009 to 2018, concerning 32 studies referring to association between carcinogenic substances to which the worker is exposed and lung cancer. RESULTS: Nine (28.1%) publications originated in China and only one in Brazil. The most exposed workers were from the secondary sector, 50% being from industry and 6.2% from construction, mostly male. Asbestos and silica stood out among the carcinogenic substances most associated with lung cancer risk, accounting for 37.5% and 28.1%, respectively. CONCLUSIONS: The association between occupational exposure and the risk for lung cancer was characterized in this research by the substantial scientific evidence from the described studies that confirm this association.

Radiographic study of the development of the pelvis and hip and the femorotibial joints in domestic cats.

OBJECTIVES: The aims of the present study were to monitor, by radiographic examination, the skeletal development of the pelvis and the femorotibial joints of the domestic cat from the first week of life until the closing of the growth plates. METHODS: Radiographic examinations were collected from 15 domestic cats at weekly intervals during the first month and every 2 weeks from the second to the fourth month of age. After that, examinations were performed monthly until the age of 18 months. RESULTS: The ischiopubic growth plate closed at 2 months of age, followed by the fusion of the iliopubic, ilioischial, proximal femoral, greater trochanter and proximal fibular growth plates. The distal femur and proximal tibial growth plates were the last to close, with fusion occurring at 18 months. The mean time to closure of the iliopubic, ilioischial and distal femoral growth plates was shorter in females. The ossification centers first appeared, in ascending order, beginning with the lesser trochanter, followed by the greater trochanter, proximal fibular epiphysis, tibial tuberosity, patella, ischial tuberosity and lateral sesamoid of the popliteus muscle. CONCLUSIONS AND RELEVANCE: The complete closure of the growth plates of domestic cats occurs at approximately 18 months of age. Skeletal maturation at approximately 18 months of age is an important parameter to be considered in radiographic evaluation of certain skeletal changes, evolution of fractures and nutritional imbalance.

Analysis of an interprofessional education activity in the occupational health field.

OBJECTIVE: to analyze the results of an Interprofessional Education activity in the ​​Occupational Health field. METHOD: this is an Action Research, which encompassed the implementation and evaluation stages of the activity. It was developed in a Public Higher Education Institution through 15 meetings, totaling 60 hours. It had 16 participants, five undergraduate students, three graduate students, five teachers and three health professionals, representing the areas of Nursing, Physical Education, Physiotherapy, Gerontology and Psychology. Data regarding the implementation of the activity were collected in a field diary and analyzed through Thematic Analysis. An evaluation form constructed exclusively for this purpose was applied, whose data were submitted to descriptive statistical analysis. RESULTS: three thematic categories were identified: (1) Comprehensive care; (2) Work as a social determinant of the health-disease process; and (3) Interprofessional teamwork. The activity of Interprofessional Education was positively evaluated by the participants, who pointed out the contributions of this strategy in the construction of knowledge directed to Occupational Health. CONCLUSION: the activity of Interprofessional Education proved to be possible and important in the context of the formation of health professions to strengthen occupational health care.