Oxidative stress mediates associations between preoperative psychosocial phenotype and pain-related outcomes at 6 months following total knee arthroplasty: a longitudinal cohort study.

OBJECTIVE: Greater preoperative depression, anxiety, and pain catastrophizing are associated with more severe long-term pain following total knee arthroplasty (TKA). In a secondary analysis of previously reported data, we tested the hypothesis that these associations are mediated by oxidative stress (OS). DESIGN: A mixed between/within-subjects longitudinal cohort design. SETTING: A single academic medical center. SUBJECTS: Osteoarthritis patients (n = 91; 62.6% female) undergoing unilateral TKA. METHODS: We assessed depression, anxiety, and catastrophizing, as well as markers of central sensitization (widespread pain, temporal summation of pain) preoperatively. Blood samples were then obtained immediately prior to intraoperative tourniquet placement for quantification of in vivo biomarkers of systemic OS, F2-isoprostanes and isofurans. Post-TKA pain intensity (numeric rating scale worst pain [NRS], McGill Pain Questionnaire-2 [MPQ-2]) and function (PROMIS Pain Interference) were assessed at 6 months following TKA. RESULTS: Greater preoperative depression, catastrophizing, and widespread pain were associated with higher intraoperative combined OS (F2-isoprostanes+isofurans/2), which was in turn associated with higher post-TKA pain intensity and worse function (P < .05). All preoperative phenotype predictors except anxiety were correlated positively with post-TKA pain and/or function (P < .05). Bootstrapped mediation analyses revealed significant (P < .05) indirect (mediated) effects of depression (NRS Worst Pain, MPQ-2, PROMIS Pain Interference), anxiety (MPQ-2, PROMIS Pain Interference), and catastrophizing (PROMIS Pain Interference) on adverse long-term post-TKA outcomes via elevated OS. Central sensitization-related predictors demonstrated only direct effects (P < .05) on post-TKA outcomes that were independent of OS mechanisms. CONCLUSIONS: Results suggest that the adverse impact of depression, anxiety, and pain catastrophizing on post-TKA pain and functional outcomes are mediated in part by elevated OS.

Deciphering pressure-induced nanoarchitectonics in a monolayer of heterocoronene-based discotics at air-water and air-solid interfaces.

Understanding and control of molecular alignment at the nanoscale in self-assembled supramolecular structures is a prerequisite for the subsequent exploitation of molecules in functional devices. Here, we have clarified the surface-pressure induced molecular nanoarchitectures in a monolayer of a heterocoronene-based discotic liquid crystal (DLC) at air-water and air-solid interfaces using surface manometry, real-time Brewster angle microscopy, and real-space atomic force microscopy (AFM). Chloroform-spread DLCs at a concentration of ∼108 µM exhibit floating domains at the air-water interface comprising small aggregates of edge-on stacked molecules interacting via peripheral alkyl chains. Detailed analysis of surface manometry and relaxation measurements reveal that, upon compression, these domains coalesce to form a coherent monolayer which then undergoes irreversible structural transformations via mechanisms such as monolayer loss due to desorption and localized nucleation of defects. AFM images of the films transferred on a hydrophilic substrate reveal that with increasing surface-pressure, the nanoscale structure of the monolayer transforms from randomly oriented nanowires to tightly-packed nanowire domains, and finally to fragmented wire segments which diffuse locally above the film. These results provide a facile method for the preparation of compact, two-dimensional films of ambipolar DLC molecules with a tunable nanoarchitecture which will be crucial for their applications in nanoscale electronic devices.

Unintentional childhood injuries and their association with activity and location at the time of injury - A case-Crossover study in Delhi.

BACKGROUND: Childhood injury has been identified as a grave public health problem globally as well as in India. Most studies have reported injuries to have occurred while the child was at home, though injuries while on road, school, or playground also commonly occurred. OBJECTIVE: The objective of the study is to find the association between unintentional childhood injury and the activity and location of the child at the time of injury. METHODS: The present study is part of a larger study for preventing childhood injuries, conducted from August 2017 to January 2019 in Delhi, and reports the activity and location of the children at the time of injury. A total of 173 injuries that occurred during the total study duration were included in the analysis. Data regarding activity and location of the subjects were collected and analyzed by case-crossover study design, during "case/hazard period" and two "control/reference periods." RESULTS: Majority of the injuries occurred while the subjects were at home and engaged in activities other than normal activity. When various locations and activities were combined, unmatched odds ratios (ORs) were raised for activity other than normal activity (statistically significant) and for location other than at home. Similar results were obtained for matched Mantel-Haenszel OR, with activity other than normal being significantly more risk for injury (P = 0.000). CONCLUSION: Majority of unintentional injuries occurred in children and adolescents, while the subjects were away from home and engaged in any activity other than normal daily activities. This indicates the importance of teaching safety behavior to children so that they can prevent being injured wherever they go and whatever activity they perform.

Spatially Resolved Magnetic Anisotropy of Cobalt Nanostructures on the Au(111) Surface.

Understanding the origin of perpendicular magnetic anisotropy in surface-supported nanoclusters is crucial for fundamental research as well as data storage applications. Here, we investigate the perpendicular magnetic anisotropy energy (MAE) of bilayer cobalt islands on Au(111) substrate using spin-polarized scanning tunneling microscopy at 4.6 K and first-principles theoretical calculations. Au(111) substrate serves as an excellent model system to study the effect of nucleation site and stacking sequence on MAE. Our measurements reveal that the MAE of bilayer islands depends strongly on the crystallographic stacking of the two Co layers and nucleation of the third layer. Moreover, the MAE of Co atoms on Au(111) is enhanced by a factor of 1.75 as compared to that reported on Cu(111). Our first-principles calculations attribute this enhancement to the large spin-orbit coupling of the Au atoms. Our results highlight the strong impact of nanometer-scale structural changes in Co islands on MAE and emphasize the importance of spatially resolved measurements for the magnetic characterization of surface-supported nanostructures.

Controlled Modification of Superconductivity in Epitaxial Atomic Layer-Organic Molecule Heterostructures.

Self-assembled organic molecules can potentially be an excellent source of charge and spin for two-dimensional (2D) atomic-layer superconductors. Here we investigate 2D heterostructures based on In atomic layers epitaxially grown on Si and highly ordered metal-phthalocyanine (MPc, M = Mn, Cu) through a variety of techniques: scanning tunneling microscopy, electron transport measurements, angle-resolved photoemission spectroscopy, X-ray magnetic circular dichroism, and ab initio calculations. We demonstrate that the superconducting transition temperature (Tc) of the heterostructures can be modified in a controllable manner. Particularly, the substitution of the coordinated metal atoms from Mn to Cu is found to reverse the Tc shift from negative to positive directions. This distinctive behavior is attributed to a competition of charge and spin effects, the latter of which is governed by the directionality of the relevant d-orbitals. The present study shows the effectiveness of molecule-induced surface doping and the significance of microscopic understanding of the molecular states in these 2D heterostructures.

Current-Driven Supramolecular Motor with In Situ Surface Chiral Directionality Switching.

Surface-supported molecular motors are nanomechanical devices of particular interest in terms of future nanoscale applications. However, the molecular motors realized so far consist of covalently bonded groups that cannot be reconfigured without undergoing a chemical reaction. Here we demonstrate that a platinum-porphyrin-based supramolecularly assembled dimer supported on a Au(111) surface can be rotated with high directionality using the tunneling current of a scanning tunneling microscope (STM). Rotational direction of this molecular motor is determined solely by the surface chirality of the dimer, and most importantly, the chirality can be inverted in situ through a process involving an intradimer rearrangement. Our result opens the way for the construction of complex molecular machines on a surface to mimic at a smaller scale versatile biological supramolecular motors.

Randomized controlled trial comparing stabilization of fresh close femoral shaft fractures in children with titanium elastic nail system versus stainless steel elastic nail system.

In vitro mechanical studies have demonstrated equal or superior fixation of pediatric femoral fractures with use of titanium elastic nails (TENS) as compared with stainless steel elastic nails (SSEN). SSEN are less expensive as compared to TENS. However, there are only two studies in the English literature which have compared the results of TENS and SSEN in paediatric femoral shaft fracture. The present study compares the clinical and radiological outcomes of femoral shaft fracture in patients 6-12 years of age, operatively stabilised either by TENS or SSEN. 35 children (6-12 years) with closed, post traumatic femoral shaft fractures were randomized into two treatment groups. Both groups underwent closed reduction internal fixation (CRIF) by either of the implants (TENS OR SSENS) as per randomization protocol and followed up for six months. Comparison of clinical and radiological outcomes in both the groups was done in terms of time to union of fracture and radiological angulations in coronal and sagittal plane. There was no significant difference in both groups with respect to fracture site tenderness and presence of bridging callus at fracture site at 3 weeks, 6 weeks and 6 months follow up (p-value = 1.000). There was no significant difference in radiological angulation rate in both groups in the sagittal (p-value = 0.661) as well as in the coronal plane (p-value = 0.219) at six month follow up. Both groups showed a similar rate of complication, most common being prominent hardware. TENS and SSENS are equally effective treatment modalities for paediatric femoral shaft fracture with similar rate of complications. However, SSENS is less costly as compared to TENS and can be considered as an alternative in a resource constrained setup.

Dual layer energy management model for optimal operation of a community based microgrid considering electric vehicle penetration.

This work develops a dual-layer energy management (DLEM) model for a microgrid (MG) consisting of a community, distributed energy resources (DERs), and a grid. It ensures the participation of all these energy entities of MG in the market and their interaction with each other. The first layer performs the scheduling operation of the community with the goal of minimizing its net-billing cost and sends the obtained schedule to the DER operator and grid. Further, the second layer formulates a power scheduling algorithm (PSA) to minimize the net-operating cost of DERs and takes into account the load demand requested by the community operator (COR). This PSA aims to achieve optimal operation of MG by considering solar PV power, requested demand, per unit grid energy prices, and state of charge of the battery energy storage system of the DER layer. Moreover, to study the impact of electric vehicles (EVs) load programs on DLEM, the advanced probabilistic EV load profile model is developed considering practical and uncertain events. The EV load is modelled for grid to vehicle mode, and a new mode of EV operation is introduced, i.e., vehicle to grid with EV demand response strategy (V2G_DRS) mode. The solar PV and load demand data are obtained from the MG setup installed and buildings present at the university campus. However, a scenario reduction technique is used to deal with the uncertainties of the obtained data. In order to evaluate the efficacy of the developed DLEM, its results are compared to previously reported energy management models. The results reveal that DLEM is superior to the existing models as it decreases the net-billing cost of COR by 13% and increases the profit of the DER operator by 17%. Further, it is found that for the highest EV penetration, i.e., 30 EVs, the V2G_DRS mode of EV operation reduces the total energy imported by COR by 11.39% and the net-billing cost of COR by 7.88%. Therefore, it can be concluded that the proposed model with the introduced V2G_DRS mode of EV makes the operation of all the entities of MG more economical and sustainable.

Quantifying Hydrogen-Bonding Interactions in the Self-Assembly of Photoresponsive Azobenzene Amphiphiles at the Air-Water Interface.

Amphiphilic azobenzene molecules offer ample scope to design functional supramolecular systems in an aqueous medium that can be controlled by light. Despite their widespread applications in photopharmacology and optoelectronics, the self-assembly pathways and energy landscapes of these systems are not well understood. Here, we report combined molecular dynamics (MD) simulation and surface manometry studies on a specially designed alkylated, meta-substituted azobenzene derivative to quantify the hydrogen-bonding interactions in the self-assembled monolayers of its photoisomers. The z-density profile, radial distribution function, order parameters, and hydrogen bond analyzed using MD simulations corroborated the experimental observations of changes in surface pressure, dipole moment, and thickness of the monolayers. Even a small change in the number of hydrogen bonds in the molecule-molecule and molecule-water interactions causes significant changes in the monolayer properties. These results are fundamentally important for engineering photoresponsive molecules with tailored properties for applications in targeted drug delivery and other industrial applications.

Liquid-Liquid Interface-Assisted Self-Assembly of Ag-Doped ZnO Nanosheets for Atomic Switch Application.

Developing facile and inexpensive methods for obtaining large-area two-dimensional semiconducting nanosheets is highly desirable for mass-scale device application. Here, we report a method for producing uniform and large-area films of a Ag-doped ZnO (AZO) nanosheet network via self-assembly at the hexane-water interface by controlling the solute/solvent ratio. The self-assembled film comprises of uniformly tiled nanosheets with size ∼1 µm and thicknesses∼60-100 nm. Using these films in a Pt/AZO/Ag structure, an atomic switch operation is realized. The switching mechanism is found to be governed by electrochemical metallization with nucleation as the rate-limiting step. Our results establish the protocol for large-scale device applications of AZO nanosheets for exploring advanced atomic switch-based neuromorphic systems.

Near-infrared spectroscopy to quantify overall thermal process intensity during high-moisture extrusion of soy protein concentrate.

High-moisture extrusion (HME) is widely used to produce meat analogues. During HME the plant-based materials experience thermal and mechanical stresses. It is complicated to separate their effects on the final products because these effects are interrelated. In this study we hypothesize that the intensity of the thermal treatment can explain a large part of the physicochemical changes that occur during extrusion. For this reason, near-infrared (NIR) spectroscopy was used as a novel method to quantify the thermal process intensity during HME. High-temperature shear cell (HTSC) processing was used to create a partial least squares (PLS) regression curve for processing temperature under controlled processing conditions (root mean standard error of cross-validation (RMSECV) = 4.00 °C, coefficient of determination of cross-validation (R2CV) = 0.97). This PLS regression model was then applied to HME extrudates produced at different screw speeds (200-1200 rpm) and barrel temperatures (100-160 °C) with two different screw profiles to calculate the equivalent shear cell temperature as a measure for thermal process intensity. This equivalent shear cell temperature reflects the effects of changes in local temperature conditions, residence time and thermal stresses. Furthermore, it can be related to the degree of texturization of the extrudates. This information can be used to gain new insights into the effect of various process parameters during HME on the thermal process intensity and extrudate quality.

Current state of the pain medicine match: perspective and an eye to the future.

The National Resident Matching Program (NRMP) for pain medicine fellowships marked its 10th anniversary in 2023, coinciding with growing discussions within the Association of Pain Program Directors (APPD) regarding the program's future in the context of a recent decline of applicants into pain medicine. This letter explores the rationale behind reassessing the NRMP's utility for pain medicine, examining historical and current trends, and considering the implications of withdrawing from the match. Despite a recent decline in applicants and an increase in unfilled positions, the APPD advocates for continued participation in the match. The match ensures equitable and stable recruitment, preventing the chaotic pre-match environment of competitive, early offers. Data from similar specialties highlight the pitfalls of non-match systems, such as increased applicant pressure and reduced program visibility. The APPD supports maintaining the NRMP match while implementing reforms like preference signaling to address evolving challenges. The APPD aims to preserve the match's benefits and ensure a stable future for pain medicine fellowship recruitment.

Visible and near-infrared spectral imaging combined with robust regression for predicting firmness, fatness, and compositional properties of fresh pork bellies.

Belly is a widely consumed pork product with very variable properties. Meat industry needs real-time quality assessment for maintaining superior pork quality throughout the production. This study explores the potential of using visible and near-infrared (VNIR,386-1015 nm) spectral imaging for predicting firmness, fatness and chemical compositional properties in pork belly samples, offering robust spectral calibrations. A total of 182 samples with wide variations in firmness and compositional properties were analysed using common laboratory analyses, whereas spectral images were acquired with a VNIR spectral imaging system. Exploratory analysis of the studied properties was performed, followed by a robust regression approach called iterative reweighted partial least-squares regression to model and predict these belly properties. The models were also used to generate spatial maps of predicted chemical compositional properties. Chemical properties such as fat, dry matter, protein, ashes, iodine value, along with firmness measures as flop distance and angle, were predicted with excellent, very good and fair models, with a ratio prediction of standard deviation (RPD) of 4.93, 3.91, 2.58, 2.54, 2.41, 2.53 and 2.51 respectively. The methodology developed in this study showed that a short wavelength spectral imaging system can yield promising results, being a potential benefit for the pork industry in automating the analysis of fresh pork belly samples. VNIR spectral imaging emerges as a non-destructive method for pork belly characterization, guiding process optimization and marketing strategies. Moreover, future research can explore advanced data analytics approaches such as deep learning to facilitate the integration of spectral and spatial information in joint modelling.

Temperature-Induced Nanoarchitectonics of Monolayer Self-Assembly of Heterocoronene-Based Discotic Liquid Crystals.

Enhancing molecular self-assembly at the monolayer level offers significant potential for various applications. For monolayers made of π-conjugated discotic liquid crystal (DLC) molecule nanowires, achieving precise separation and alignment of these nanowires has been a long-standing challenge. This research explores an approach using the manipulation of subphase temperature and surface pressure within a Langmuir trough to control molecular nanowire separation. We observe notable temperature-dependent behavior: as the temperature increases from 5 to 30 °C, the monolayer collapse pressure rises steadily. In contrast, temperatures from 35 to 50 °C exhibit an initial small plateau with a nonzero slope that becomes more distinct with rising temperature. Our study of Langmuir-Blodgett (LB) films provides crucial insights into the monolayer's structure. At lower temperatures, the LB films show coalesced molecular nanowires, whereas at higher temperatures, the DLC nanowires separate and form an interconnected network. Remarkably, upon compression, this network transforms into a compact, highly uniform monolayer. To explain these temperature-dependent behaviors, we examine the area relaxation curves, which indicate a two-step molecular loss mechanism involving desorption and monolayer collapse due to the nucleation and growth of critical nuclei. This extensive study offers valuable insights into the dynamic interaction of the temperature, surface pressure, and molecular assembly, enhancing our understanding of the fundamental processes in monolayer self-assembly.

The design and baseline characteristics for the HOPE Consortium Trial to reduce pain and opioid use in hemodialysis.

The HOPE Consortium Trial to Reduce Pain and Opioid Use in Hemodialysis (HOPE Trial) is a multicenter randomized trial addressing chronic pain among patients receiving maintenance hemodialysis for end-stage kidney disease. The trial uses a sequential, multiple assignment design with a randomized component for all participants (Phase 1) and a non-randomized component for a subset of participants (Phase 2). During Phase 1, participants are randomized to Pain Coping Skills Training (PCST), an intervention designed to increase self-efficacy for managing pain, or Usual Care. PCST consists of weekly, live, coach-led cognitive behavioral therapy sessions delivered by video- or tele-conferencing for 12 weeks followed by daily interactive voice response sessions delivered by telephone for an additional 12 weeks. At 24 weeks (Phase 2), participants in both the PCST and Usual Care groups taking prescription opioid medications at an average dose of ≥20 morphine milligram equivalents per day are offered buprenorphine, a partial opioid agonist with a more favorable safety profile than full-agonist opioids. All participants are followed for 36 weeks. The primary outcome is pain interference ascertained, for the primary analysis, at 12 weeks. Secondary outcomes include additional patient-reported measures and clinical outcomes including falls, hospitalizations, and death. Exploratory outcomes include acceptability, tolerability, and efficacy of buprenorphine. The enrollment target of 640 participants was met 27 months after trial initiation. The findings of the trial will inform the management of chronic pain, a common and challenging issue for patients treated with maintenance hemodialysis. NCT04571619.

Sequentially orthogonalized canonical partial least squares for improved multiple responses modeling in multiblock data sets.

Multiblock data sets and modeling techniques are widely encountered in the chemometric community. Although the currently available techniques, such as sequential orthogonalized partial least squares (SO-PLS) regression are mainly focused on the prediction of a single response and deal with the multiple response(s) case using PLS2 type approach. Recently, a new approach called canonical PLS (CPLS) was proposed for extracting the subspaces efficiently for multiple response(s) cases, supporting both regression and classification. 'Efficiently' here means more information in fewer latent variables. This work suggests a combination of SO-PLS and CPLS, sequential orthogonalized canonical partial least squares (SO-CPLS), to model multiple response(s) for multiblock data sets. The cases of SO-CPLS for modeling multiple response(s) regression and classification were demonstrated on several data sets. Also, the capability of SO-CPLS to incorporate meta-information related to samples for efficient subspace extraction is demonstrated. Furthermore, a comparison with the commonly used sequential modeling technique, called sequential orthogonalized partial least squares (SO-PLS), is also presented. The SO-CPLS approach can benefit both the multiple response(s) regression and classification modeling and can be of high importance when meta-information such as experimental design or sample classes is available.

An improved nonlinear deloading approach based on the fuzzy controller for wind turbine generators in an islanded microgrid.

The wind turbine generators (WTG's) incapability of primary frequency support during system contingencies due to its decoupled nature from the system frequency causes profound integration and stability issues. The present study focuses on resolving such issues by enabling the WTGs to participate in long-term frequency support under the derated operation of WTGs. The deloading operation of WTGs can provide a specific reserve power margin by reducing its rotor speed, which can be utilized during system contingencies. In literature, linear and quadratic deloading techniques have been proposed but these fail to replicate the nonlinear characteristics of the WTG accurately, thereby making deloading ineffective. To effectively implement the deloading, this work uses a more-accurate higher-order Newton's interpolation polynomial (HNIP), to cope with the highly nonlinear characteristics of WTG. The proposed deloading approach is also augmented with a fuzzy-based intelligent supplementary control structure to handle the inherent and incorporated nonlinearities in WTG. The microgrid system, consisting of a conventional energy source with WTG, has been considered as system under investigation. The integral time absolute error for step wind profile and variable speed wind profile was found to be improved by 97.65% and 97.29%, respectively, with the proposed novel deloading technique with fuzzy-PID compared to PID. Further, to ensure the implementation viability of the proposed control scheme, real-time validation of the same is carried out on OPAL-RT 4510, having a Xilinx Kintex-7 FPGA board. It was found that for all the scenarios considered for real-time digital simulation purposes, the results unerringly matched with MATLAB/Simulink.

Perioperative oxidative stress predicts subsequent pain-related outcomes in the 6 months after total knee arthroplasty.

ABSTRACT: Total knee arthroplasty (TKA) is effective for pain reduction in most patients, but 15% or more report unsatisfactory long-term pain outcomes. We tested whether oxidative stress (OS) related to extended tourniquet application during TKA and subsequent ischemic reperfusion (IR) contributed to adverse post-TKA pain outcomes. Blood samples were obtained in 91 patients with osteoarthritis (63% female) undergoing TKA before tourniquet placement (T1), 45 minutes after tourniquet inflation (T2), and 15 minutes after tourniquet removal (T3). Plasma levels of F 2 -isoprostanes and isofurans, the most specific measures of in vivo OS, were quantified. Pain intensity and function were assessed at baseline and again at 6 weeks and 6 months after TKA. Results indicated that higher Combined OS (F 2 -isoprostanes + isofurans/2) at T1 baseline and larger increases in Combined OS from T1 to T2 were associated with higher baseline-corrected past 24-hour worst and average pain intensity (numeric rating scale) and higher past week McGill Pain Questionnaire-2 total scores at 6-month follow-up ( P 's < 0.05). Increases in Combined OS from T1 to T3, which should most directly capture OS and IR injury related to tourniquet use, were not associated with short-term or long-term post-TKA pain outcomes. Longer ischemia duration was unexpectedly associated with lower baseline-corrected pain intensity at 6-month follow-up. Combined OS was not linked to functional outcomes at either follow-up. Elevated perioperative OS seems to exert small but significant adverse effects on long-term post-TKA pain outcomes, although this OS seems unrelated to IR injury associated with extended tourniquet use.

Preoperative Predictors of Prolonged Opioid Use in the 6 Months After Total Knee Arthroplasty.

OBJECTIVES: Prolonged postoperative opioid use increases the risk for new postsurgical opioid use disorder. We evaluated preoperative phenotypic factors predicting prolonged postoperative opioid use. METHODS: We performed a secondary analysis of a prospective observational cohort (n=108) undergoing total knee arthroplasty (TKA) for osteoarthritis with 6-week and 6-month follow-up. Current opioid use and psychosocial, pain, and opioid-related characteristics were assessed at preoperative baseline. Primary outcomes were days/week of opioid use at follow-up. RESULTS: At 6 weeks, preoperative opioid use and greater cumulative opioid exposure, depression, catastrophizing, anxiety, pain interference, sleep disturbance, and central sensitization were significantly associated with more days/week of opioid use after controlling for contemporaneous pain intensity. Prior euphoric response to opioids were also significant predictors at 6 months. All 6-week predictors except anxiety remained significant after controlling for preoperative opioid use; at 6 months, cumulative opioid exposure, catastrophizing, pain interference, and sleep disturbance remained significant after this adjustment ( P <0.05). In multivariable models, a psychosocial factor reflecting negative affect, sleep, and pain accurately predicted 6-week opioid use (area under the curve=0.84). A combined model incorporating psychosocial factor scores, opioid-related factor scores, and preoperative opioid use showed near-perfect predictive accuracy at 6 months (area under the curve=0.97). DISCUSSION: Overall, preoperative psychosocial, pain-related, and opioid-related phenotypic characteristics predicted prolonged opioid use after total knee arthroplasty.

Deep generative neural networks for spectral image processing.

An artificial intelligence approach based on deep generative neural networks for spectral imaging processing was proposed. The key idea was to treat different spectral image processing operations such as segmentation, regression, and classification as image-to-image translation tasks. For the image-to-image translation, the conditional generative adversarial networks were used. As a baseline comparison, the traditional chemometric approach based on pixels wise modelling was demonstrated. The analysis was presented with two real data sets related to fruit property prediction and kernel and shell classification of walnuts. The presented artificial intelligence approach for spectral image processing can provide benefits for any field of science where spectral imaging and processing is widely performed.