[Lipoprotein metabolism disorders in hypertension with a cerebral syndrome and their diagnostic value for medico-occupational expertise]. / Osobennosti narushenii lipoproteinovogo obmena pri gipertonicheskoi bolezni s tserebral'nym sindromom i ikh diagnosticheskoe znachenie dlia vrachebno-trudovoi ékspertizy

On the basis of a profound clinico-biochemical study of 182 patients with hypertensive disease the authors established that the development of chronic insufficiency of cerebral circulation in this disorder is accompanied by quantitative and physico-chemical changes in the lipoprotein metabolism. These indices do not change significantly following short sessions of heparinotherpy and comprehensive treatment. Their diagnostical significance for medico-occupational examinations is discussed.

[Disorders in lipoprotein metabolism indices in cerebral atherosclerosis, their importance for diagnosis and medical-occupational expertise]. / Osobennosti narushenii pokazatelei lipoproteinovogo obmena pri tserebral'nom ateroskleroze, ikh znachenie dlia diagnostiki i vrachebno-trudovoi ékspertizy.

Using a wide complex of biochemical indices 166 patients with cerebral atherosclerosis were examined. It was shown that in this disease regardless of the period of acute stage a deficiency of the brain circulation of physicochemical changes of the serum proteins, lipoproteins and an oppression of the process of cholesterol exterfication precede quantitative accumulation of total cholesterol in the blood, beta-lipoproteins, a decrease of the lecethin level and changes of protein fractions. Heparin treatment along with improvement of the patients' clinical state, indices of general and brain hemodynamics decreased a free cholesterol level, increased the strength of cholesterol and apoprotein relationship and phosphorolipid content in the blood. In the author's opinion one of the leading causes of lipoprotein metabolic disorders in atherosclerosis can be a change of hormonal regulation of the activity in proteins enzymes of the organs and tissues, including the enzymes regulating an oxidation-reduction process in the organism. The significance of the studied indices for diagnosis and medical labour examination is considered.

[Coagulation properties of the blood and effectiveness of heparin therapy in patients with the cerebral form of hypertension and atherosclerosis]. / Koaguliatsionnye svoistva krovi i klinicheskaia éffektivnost' lecheniia geparinom bol'nykh tserebral'noi formoi gipertonicheskoi bolezni i ateroskleroza

By means of clinical and instrumental diagnosis the authors displayed a high effectiveness in the preventive treatment of patients with atherosclerosis and hypertensive disease by heparin in the period of remission. At the same time following treatment some patients especially with hypertensive disease revealed a marked activation of the hypercoagulative blood properties which exceeded the intial level. The authors discuss the possible mechanisms of this reaction.