Association of Glasgow coma scale and endotracheal intubation in predicting mortality among patients admitted to the intensive care unit.

BACKGROUND: We assessed predictors of mortality in the intensive care unit (ICU) and investigated if Glasgow coma scale (GCS) is associated with mortality in patients undergoing endotracheal intubation (EI). METHODS: From February 2020, we performed a 1-year study on 2,055 adult patients admitted to the ICU of two teaching hospitals. The outcome was mortality during ICU stay and the predictors were patients' demographic, clinical, and laboratory features. RESULTS: EI was associated with a decreased risk for mortality compared with similar patients (adjusted odds ratio [AOR], 0.32; P=0.030). This shows that EI had been performed correctly with proper indications. Increasing age (AOR, 1.04; P<0.001) or blood pressure (AOR, 1.01; P<0.001), respiratory problems (AOR, 3.24; P<0.001), nosocomial infection (AOR, 1.64; P=0.014), diabetes (AOR, 5.69; P<0.001), history of myocardial infarction (AOR, 2.52; P<0.001), chronic obstructive pulmonary disease (AOR, 3.93; P<0.001), immunosuppression (AOR, 3.15; P<0.001), and the use of anesthetics/sedatives/hypnotics for reasons other than EI (AOR, 4.60; P<0.001) were directly; and GCS (AOR, 0.84; P<0.001) was inversely related to mortality. In patients with trauma surgeries (AOR, 0.62; P=0.014) or other surgical categories (AOR, 0.61; P=0.024) undergoing EI, GCS had an inverse relation with mortality (accuracy=82.6%, area under the receiver operator characteristic curve=0.81). CONCLUSIONS: A variety of features affected the risk for mortality in patients admitted to the ICU. Considering GCS score for EI had the potential of affecting prognosis in subgroups of patients such as those with trauma surgeries or other surgical categories.

Management of Hemorrhagic Fever Viruses: Intervention of Natural and Synthetic Products.

BACKGROUND: Viral hemorrhagic fevers (VHFs) are a group of clinical syndromes caused by several different RNA virus families, including several members of the arenavirus, bunyavirus, filovirus, and flavivirus families. VHFs have high mortality rates, and they have been associated with vascular permeability, malaise, fever, variable degrees of hemorrhage, reduced plasma volume, and coagulation abnormalities. To treat such conditions, antigen-presenting cells target dysregulated immune reactions and productive infections. Monocytes and macrophages produce inflammatory cytokines that damage adaptive immunity, while infected dendritic cells fail to mature correctly, compromising adaptive immunity. Inflammation and uncontrolled virus replication are associated with vascular leakage and coagulopathy. OBJECTIVE: VHF infects both humans and animals and if not treated, causes hemorrhagic manifestations and lethal platelet dysfunction. Besides pharmacological and immunological solutions, the intervention of natural products for VHF management is of great interest. In this review, we gathered current data about the effectiveness of natural products for VHF management. METHODS: Data were extracted from Scopus, Google Scholar, PubMed, and Cochrane library in terms of clinical and animal studies published in English between 1981 to February 2022. RESULTS: Several plants from diverse families and species were identified with antiviral activity against VHF. The combination of botanical therapeutics and multitarget synergistic therapeutic effects is now the widely accepted explanation for the treatment of VHF. Most of these herbal therapeutics have shown promising immunomodulatory effects in vivo and in vitro VHF models. They can probably modulate the immune system in VHF-infected subjects mainly by interfering with certain inflammatory mediators involved in various infectious diseases. CONCLUSION: Natural, in particular, herbal sources can be valuable for the management of various VHFs and their related complications.

A comprehensive review of the articles published in the field of health in emergencies and disasters in Iran.

Introduction: Iran is one of the most disaster-prone countries in the world. A research-based approach is essential to reduce the effects of disasters and provide effective responses. This study aims to review the articles published in the field of emergencies and disasters in Iran. Methods: a combination of descriptive and qualitative content analysis using Hsieh and Shannon´s method was done. Since the first and most well-known specialized journal in the field of emergencies and disasters in Iran is the Health in emergencies and Disasters Quarterly (HDQ), all articles published in this journal were examined in terms of theme and scientometric indicators. Results: regarding the type of research, 103 were quantitative (66.5%), 18 were qualitative (11.6%), and 4 (2.6%) were performed by mixed method. Most of the articles (n=116, 76.3%) were original research. The most frequently studied risk was traffic accidents (n=17, 10.96%) followed by earthquakes (n=10, 6.45%) and floods (n=8, 5.16%). In terms of theme and content, 103 published articles were related to one of the 4 main phases of the disaster risk management cycle where most of them were related to preparedness (n=48, 46.6%) followed by mitigation (n=26, 25.24%), response (n=20, 19.42%), and recovery (n=9, 8.47%) phases. Conclusion: although there are studies related to the four phases of disaster risk management cycle in Iran, most of them are related to assessing preparedness followed by mitigation. In addition, qualitative and mixed studies could have more significant contribution to this field of research, accelerating this process requires the development of disaster research methodology training and researcher training programs as well as their organized and financial support.