RESUMEN
L-DOPA, which is a metabolic precursor of catecholamines, reduced the manifestations of hyperlipidemia developed in animals after administration of Triton WR-1339, dexametasone or cholesterol. At the same time, L-DOPA decreased the rate of lipolysis, induced by adrenaline injection, as well as the content of 11-hydrocorticosteroids in blood plasma.
Asunto(s)
Levodopa/farmacología , Metabolismo de los Lípidos , Animales , Colesterol/farmacología , Detergentes/farmacología , Dexametasona/farmacología , Epinefrina/farmacología , Cobayas , Hiperlipidemias/metabolismo , Movilización Lipídica/efectos de los fármacos , Masculino , Ratones , Polietilenglicoles/farmacología , RatasRESUMEN
Experiments on rabbits with experimental cholesterol atherosclerosis have shown bisanions :formula: see text.
Asunto(s)
Arteriosclerosis/tratamiento farmacológico , Hipolipemiantes , Animales , Aniones , Clofibrato/uso terapéutico , Evaluación Preclínica de Medicamentos , Hiperlipidemias/tratamiento farmacológico , Masculino , Conejos , Ratas , Sulfitos/uso terapéutico , Factores de TiempoRESUMEN
Experiments on rabbits which received cholesterol in food for 3-4 months showed an inhibitory effect of ethirazol (bis-methylamide-1-ethyl-pyrazol-3,4-bicarbonic acid) and parmidine (piridinolcarbamate, 2,6-bis-hydroxymethylpiridine bis-n-methylcarbamate) on the development of experimental atherosclerosis: there proved to be a reduction of accumulation of total cholesterol in the aorta and of its atherosclerotic affection. At the same time the blood serum cholesterol, triglycerids and phospholipid content was not significantly changed by these drugs.
Asunto(s)
Arteriosclerosis/prevención & control , Carbamatos/uso terapéutico , Pirazoles/uso terapéutico , Piridinolcarbamato/uso terapéutico , Animales , Anticolesterolemiantes/uso terapéutico , Dieta Aterogénica , Masculino , ConejosRESUMEN
Chronic irritation of the falsely operated rats and those with the deafferentated hypothalamus led to reduction of total blood cholesterol and the accumulation of triglycerides in the liver. Dexamethasone administration was accompanied by an increase of blood cholesterol and triglycerides and the triglyceride accumulation in the liver. The action of dexamethasone was more pronounced in the animals with the deafferentated hypothalamus. The rate of 11-oxycorticosteroid secretion into the adrenal vein is reduced in the latter.