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1.
J Genet Eng Biotechnol ; 16(1): 105-113, 2018 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-30647712

RESUMEN

The present work illustrates eco-friendly, rapid and cost effective method of AgNPs synthesis using C. pulcherrima stem extract. Initially, various physico chemical factors were optimized. Characterization was done by different spectroscopic and microscopic analysis. AgNPs were spherical in shape with an average size of 8 nm. AgNPs showed good synergistic antimicrobial, antibiofilm and antioxidant activity. The cytotoxicity effect against HeLa cancer cell line was dose dependent while genotoxic study revealed the non toxic nature of AgNPs at lower concentration. The results suggest that AgNPs from C. pulcherrima stem extract have great potential in biomedical applications.

2.
Artif Cells Nanomed Biotechnol ; 45(8): 1556-1567, 2017 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-27900878

RESUMEN

Caesalpinia pulcherrima flower extract mediated synthesis of silver nanoparticles was attempted in the present work including optimization of some procedure parameters. Characterization of synthesized silver nanoparticles was done by various spectral analyses. The size of synthesized silver nanoparticles was 12 nm and they were spherical in shape. The green synthesized silver nanoparticles were further evaluated for antimicrobial, antioxidant, cytotoxic, and genotoxic activities; they showed good antimicrobial, antioxidant, and cytotoxic effects. Genotoxic study revealed non-toxic nature at lower concentration. Overall results suggest that the synthesized silver nanoparticles have pronounced applicability in pharmaceutical and biomedical field.


Asunto(s)
Caesalpinia/química , Flores/química , Nanopartículas del Metal/química , Extractos Vegetales/química , Plata/química , Plata/farmacología , Antiinfecciosos/síntesis química , Antiinfecciosos/química , Antiinfecciosos/farmacología , Antiinfecciosos/toxicidad , Antioxidantes/síntesis química , Antioxidantes/química , Antioxidantes/farmacología , Antioxidantes/toxicidad , Técnicas de Química Sintética , Aberraciones Cromosómicas/efectos de los fármacos , Tecnología Química Verde , Células HeLa , Humanos , Leucocitos Mononucleares/efectos de los fármacos , Pruebas de Sensibilidad Microbiana , Mutágenos/síntesis química , Mutágenos/química , Mutágenos/farmacología , Mutágenos/toxicidad , Nanotecnología , Tamaño de la Partícula , Plata/toxicidad
3.
J Genet Eng Biotechnol ; 15(2): 505-513, 2017 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-30647693

RESUMEN

In this work, we report for the first time, synthesis of silver nanoparticles using Cassia roxburghii leaf extract and evaluate its synergistic antibacterial efficacy and antioxidant potential. The synergistic antimicrobial activity of silver nanoparticles with commercial antibiotics against Gram-positive, Gram-negative bacteria and fungi was evaluated. The antioxidant potential of synthesized silver nanoparticles was evaluated by FRAP and ABTS radical scavenging antioxidant assays. UV-Vis spectra peak at 473 and color change from colorless to brown color confirmed the formation of AgNPs. X-ray diffraction (XRD) and selected area electron diffraction (SAED) pattern confirmed the crystalline nature of synthesized nanoparticles. Transmission electron microscopy (TEM) analysis revealed the average size of particles to be 15-20 nm. Fourier transform infrared spectroscopy (FTIR) revealed the functional groups C. roxburghii leaf that was responsible for the reduction and capping process of nanoparticles. C. roxburghii leaf extract synthesized AgNPs showed good synergistic antimicrobial against Gram-negative bacteria even better than some of the antibiotics used as positive control; they also showed antioxidant potential. The results suggest that the synthesized nanoparticles can be used to treat multidrug resistant microorganisms and stress related diseases and disorders.

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