Non-invasive prehabilitation to foster widespread fMRI cortical reorganization before brain tumor surgery: lessons from a case series.

PURPOSE: The objective of this prospective, single-centre case series was to investigate feasibility, clinical outcomes, and neural correlates of non-invasive Neuromodulation-Induced Cortical Prehabilitation (NICP) before brain tumor surgery. Previous studies have shown that gross total resection is paramount to increase life expectancy but is counterbalanced by the need of preserving critical functional areas. NICP aims at expanding functional margins for extensive tumor resection without functional sequelae. Invasive NICP (intracranial neuromodulation) was effective but characterized by elevated costs and high rate of adverse events. Non-invasive NICP (transcranial neuromodulation) may represent a more feasible alternative. Nonetheless, up to this point, non-invasive NICP has been examined in only two case reports, yielding inconclusive findings. METHODS: Treatment sessions consisted of non-invasive neuromodulation, to transiently deactivate critical areas adjacent to the lesion, coupled with intensive functional training, to activate alternative nodes within the same functional network. Patients were evaluated pre-NICP, post-NICP, and at follow-up post-surgery. RESULTS: Ten patients performed the intervention. Feasibility criteria were met (retention, adherence, safety, and patient's satisfaction). Clinical outcomes showed overall stability and improvements in motor and executive function from pre- to post-NICP, and at follow-up. Relevant plasticity changes (increase in the distance between tumor and critical area) were observed when the neuromodulation target was guided by functional neuroimaging data. CONCLUSION: This is the first case series demonstrating feasibility of non-invasive NICP. Neural correlates indicate that neuroimaging-guided target selection may represent a valid strategy to leverage neuroplastic changes before neurosurgery. Further investigations are needed to confirm such preliminary findings.

Validation and Normative Data of the Spanish Version of the Face Name Associative Memory Exam (S-FNAME).

OBJECTIVE: The relevance of the episodic memory in the prediction of brain aging is well known. The Face Name Associative Memory Exam (FNAME) is a valued associative memory measure related to Alzheimer's disease (AD) biomarkers, such as amyloid-ß deposition preclinical AD individuals. Previous validation of the Spanish version of the FNAME test (S-FNAME) provided normative data and psychometric characteristics. The study was limited to subjects attending a memory clinic and included a reduced sample with gender inequality distribution. The purpose of this study was to assess S-FNAME psychometric properties and provide normative data in a larger independent sample of cognitively healthy individuals. METHOD: S-FNAME was administered to 511 cognitively healthy volunteers (242 women, aged 41-65 years) participating in the Barcelona Brain Health Initiative cohort study. RESULTS: Factor analysis supported construct validity revealing two underlying components: face-name and face-occupation and explaining 95.34% of the total variance, with satisfactory goodness of fit. Correlations between S-FNAME and Rey Auditory-Verbal Learning Test were statistically significant and confirmed its convergent validity. We also found weak correlations with non-memory tests supporting divergent validity. Women showed better scores, and S-FNAME was positively correlated with education and negatively with age. Finally, we generated normative data. CONCLUSIONS: The S-FNAME test exhibits good psychometric properties, consistent with previous findings, resulting in a valid and reliable tool to assess episodic memory in cognitively healthy middle-aged adults. It is a promising test for the early detection of subtle memory dysfunction associated with abnormal brain aging.

Technologies for Monitoring Lifestyle Habits Related to Brain Health: A Systematic Review.

Brain health refers to the preservation of brain integrity and function optimized for an individual's biological age. Several studies have demonstrated that our lifestyles habits impact our brain health and our cognitive and mental wellbeing. Monitoring such lifestyles is thus critical and mobile technologies are essential to enable such a goal. Three databases were selected to carry out the search. Then, a PRISMA and PICOTS based criteria for a more detailed review on the basis of monitoring lifestyle aspects were used to filter the publications. We identified 133 publications after removing duplicates. Fifteen were finally selected from our criteria. Many studies still use questionnaires as the only tool for monitoring and do not apply advanced analytic or AI approaches to fine-tune results. We anticipate a transformative boom in the near future developing and implementing solutions that are able to integrate, in a flexible and adaptable way, data from technologies and devices that users might already use. This will enable continuous monitoring of objective data to guide the personalized definition of lifestyle goals and data-driven coaching to offer the necessary support to ensure adherence and satisfaction.

Lifestyle trajectories in middle-aged adults and their relationship with health indicators.

Introduction: Understanding the impact of different lifestyle trajectories on health preservation and disease risk is crucial for effective interventions. Methods: This study analyzed lifestyle engagement over five years in 3,013 healthy adults aged 40-70 from the Barcelona Brain Health Initiative using K-means clustering. Nine modifiable risk factors were considered, including cognitive, physical, and social activity, vital plan, diet, obesity, smoking, alcohol consumption, and sleep. Self-reported diagnoses of new diseases at different time-points after baseline allowed to explore the association between these five profiles and health outcomes. Results: The data-driven analysis classified subjects into five lifestyle profiles, revealing associations with health behaviors and risk factors. Those exhibiting high scores in health-promoting behaviors and low-risk behaviors, demonstrate a reduced likelihood of developing diseases (p < 0.001). In contrast, profiles with risky habits showed distinct risks for psychiatric, neurological, and cardiovascular diseases. Participant's lifestyle trajectories remained relatively stable over time. Discussion: Our findings have identified risk for distinct diseases associated to specific lifestyle patterns. These results could help in the personalization of interventions based on data-driven observation of behavioral patterns and policies that promote a healthy lifestyle and can lead to better health outcomes for people in an aging society.

Exploring the neural basis of non-invasive prehabilitation in brain tumour patients: An fMRI-based case report of language network plasticity.

Primary brain neoplasms are associated with elevated mortality and morbidity rates. Brain tumour surgery aims to achieve maximal tumour resection while minimizing damage to healthy brain tissue. Research on Neuromodulation Induced Cortical Prehabilitation (NICP) has highlighted the potential, before neurosurgery, of establishing new brain connections and transfer functional activity from one area of the brain to another. Nonetheless, the neural mechanisms underlying these processes, particularly in the context of space-occupying lesions, remain unclear. A patient with a left frontotemporoinsular tumour underwent a prehabilitation protocol providing 20 sessions of inhibitory non-invasive neuromodulation (rTMS and multichannel tDCS) over a language network coupled with intensive task training. Prehabilitation resulted in an increment of the distance between the tumour and the language network. Furthermore, enhanced functional connectivity within the language circuit was observed. The present innovative case-study exposed that inhibition of the functional network area surrounding the space-occupying lesion promotes a plastic change in the network's spatial organization, presumably through the establishment of novel functional pathways away from the lesion's site. While these outcomes are promising, prudence dictates the need for larger studies to confirm and generalize these findings.

"Guttmann Cognitest®," a digital solution for assessing cognitive performance in adult population: A feasibility and usability pilot study.

Background: As the world population continues to age, the prevalence of neurological diseases, such as dementia, poses a significant challenge to society. Detecting cognitive impairment at an early stage is vital in preserving and enhancing cognitive function. Digital tools, particularly mHealth, offer a practical solution for large-scale population screening and prompt follow-up assessments of cognitive function, thus overcoming economic and time limitations. Objective: In this work, two versions of a digital solution called Guttmann Cognitest® were tested. Methods: Two hundred and one middle-aged adults used the first version (Group A), while 132 used the second one, which included improved tutorials and practice screens (Group B). This second version was also validated in an older age group (Group C). Results: This digital solution was found to be highly satisfactory in terms of usability and feasibility, with good acceptability among all three groups. Specifically for Group B, the system usability scale score obtained classifies the solution as the best imaginable in terms of usability. Conclusions: Guttmann Cognitest® has been shown to be effective and well-perceived, with a high potential for sustained engagement in tracking changes in cognitive function.

Impact of repetitive negative thinking on subjective cognitive decline: insights into cognition and brain structure.

Introduction: Individuals with subjective cognitive decline (SCD) express concern about self-perceived cognitive decline despite no objective impairment and are at higher risk of developing Alzheimer's disease. Despite documented links between SCD and repetitive negative thinking (RNT), the specific impact of RNT on brain integrity and cognition in exacerbating the SCD condition remains unclear. We aimed to investigate the influence of RNT on global cognition and brain integrity, and their interrelationships among healthy middle-aged and older adults experiencing SCD. Methods: Out of 616 individuals with neuroimaging and neuropsychological data available, 89 (mean age = 56.18 years; 68.54% females) met SCD criteria. Eighty-nine non-SCD individuals matched by age, sex, and education were also selected and represented the control group (mean age = 56.09 years; 68.54% females). Global cognition was measured using the preclinical Alzheimer's cognitive composite (PACC5), which includes dementia screening, episodic memory, processing speed, and category fluency tests. RNT was calculated through three questionnaires assessing intrusive thoughts, persistent worry, and rumination. We generated cortical thickness (CTh) maps and quantified the volume of white matter lesions (WML) in the whole brain, as grey and white matter integrity measures, respectively. Results: SCD individuals exhibited higher RNT scores, and thinner right temporal cortex compared to controls. No differences were observed in PACC5 and WML burden between groups. Only the SCD group demonstrated positive associations in the CTh-PACC5, CTh-RNT, and WML-RNT relationships. Discussion: In this cross-sectional study, RNT was exclusively associated with brain integrity in SCD. Even though our findings align with the broader importance of investigating treatable psychological factors in SCD, further research may reveal a modulatory effect of RNT on the relationship between cognition and brain integrity in SCD.

Neuromodulation-induced prehabilitation to leverage neuroplasticity before brain tumor surgery: a single-cohort feasibility trial protocol.

Introduction: Neurosurgery for brain tumors needs to find a complex balance between the effective removal of targeted tissue and the preservation of surrounding brain areas. Neuromodulation-induced cortical prehabilitation (NICP) is a promising strategy that combines temporary inhibition of critical areas (virtual lesion) with intensive behavioral training to foster the activation of alternative brain resources. By progressively reducing the functional relevance of targeted areas, the goal is to facilitate resection with reduced risks of neurological sequelae. However, it is still unclear which modality (invasive vs. non-invasive neuromodulation) and volume of therapy (behavioral training) may be optimal in terms of feasibility and efficacy. Methods and analysis: Patients undertake between 10 and 20 daily sessions consisting of neuromodulation coupled with intensive task training, individualized based on the target site and neurological functions at risk of being compromised. The primary outcome of the proposed pilot, single-cohort trial is to investigate the feasibility and potential effectiveness of a non-invasive NICP protocol on neuroplasticity and post-surgical outcomes. Secondary outcomes investigating longitudinal changes (neuroimaging, neurophysiology, and clinical) are measured pre-NICP, post-NICP, and post-surgery. Ethics and dissemination: Ethics approval was obtained from the Research Ethical Committee of Fundació Unió Catalana d'Hospitals (approval number: CEI 21/65, version 1, 13/07/2021). The results of the study will be submitted to a peer-reviewed journal and presented at scientific congresses. Clinical trial registration: ClinicalTrials.gov, identifier NCT05844605.

Brain Connectivity Correlates of Cognitive Dispersion in a Healthy Middle-Aged Population: Influence of Subjective Cognitive Complaints.

OBJECTIVES: Cognitive dispersion, representing intraindividual fluctuations in cognitive performance, is associated with cognitive decline in advanced age. We sought to elucidate sociodemographic, neuropsychological, and brain connectivity correlates of cognitive dispersion in middle age, and further consider potential influences of the severity of subjective cognitive complaints (SCC). METHODS: Five hundred and twenty healthy volunteers from the Barcelona Brain Health Initiative (aged 40-66 years; 49.6% females, 453 with magnetic resonance imaging acquisitions) were included and stratified into high and low SCC groups. Two analysis steps were undertaken: (1) for the whole sample and (2) by groups. Generalized linear models and analysis of covariance were implemented to study associations between cognitive dispersion and performance (episodic memory, speed of processing, and executive function), white matter integrity, and resting-state functional connectivity (rs-FC) of the default mode network (DMN) and dorsal attentional networks (DAN). RESULTS: Across-domain dispersion was negatively related to cognitive performance, rs-FC within the DMN, and between the DMN and the DAN, but not to white matter integrity. The rs-FC values were not explained by cognitive performance. When considering groups, the above findings were significant only for those with high SCC. DISCUSSION: In healthy middle-aged individuals, high cognitive dispersion was related to poorer cognition and DMN dysregulation, being these associations stronger among subjects with high SCC. The present results reinforce the interest in considering dispersion measures within neuropsychological evaluations, as they may be more sensitive to incipient age-related cognitive and functional brain changes than traditional measures of performance.

GLP1 analogues among patients with overweight or obesity during lockdown. / Análogos de GLP1 en los pacientes con sobrepeso u obesidad durante el confinamiento.

BACKGROUND AND OBJECTIVES: One of the potential negative effects of a lockdown are changes in dietary and lifestyle patterns, which can lead to weight gain. Our objective was to assess the changes on dietary habits and eating patterns in a lockdown situation and their impact on weight. We aimed to determine whether the treatment with GLP1 analogues (aGLP1) could impact on these parameters. MATERIAL AND METHODS: 100 overweight/obese patients were consecutively recruited for a review at the end of the lockdown. A structured interview was designed to see changes in dietary habits, routines and exercise. RESULTS: 52% patients gained weight during lockdown. The percentage of subjects with an active history of depression or anxiety was higher among the group of patients who gained weight. The percentage of patients who worsened their hyperphagia was higher in those who gained weight (71.2% vs. 10.6%; P<0.0001); similar results were observed with binge eating (92% vs. 10.6%; p<0.0001) and cravings, both sweet and salty (69.2% vs. 21.3% and 69.2% vs. 14.9%; p<0.0001 and p<0.0001 respectively). Of the 48 patients who did not gain weight, 30 were under aGLP1 treatment (61.7%). The worsening of abnormal eating patterns was lower among patients treated with aGLP-1. CONCLUSIONS: A lockdown is a vulnerable period to gain weight, especially in those patients with a psychopathological history. aGLP1 manage to control emotional eating, making them a valuable therapeutic option.

"Guttmann Cognitest"®, preliminary validation of a digital solution to test cognitive performance.

Thanks to technological advances, the administration of cognitive assessments via digital solutions continues to increase, both in research and clinical practice. "Guttmann Cognitest"°ledR is a digital solution for cognitive assessment which includes seven computerized tasks designed to assess main cognitive functions requiring approximately 20 min to be completed. The purpose of the present study was to validate it against standard and more extensive in-person neuropsychological assessments in the context of the Barcelona Brain Health Initiative (BBHI) cohort study. We studied 274 participants of the BBHI (126 women, mean age = 56.14, age range 44-69), who underwent an extensive in-person assessment, including a classical paper-and-pencil neuropsychological assessment and a cognitive assessment via the "Guttmann Cognitest"°ledR. Principal component analysis indicated that "Guttmann Cognitest"°ledR measures four main cognitive domains and convergent validity analysis demonstrated that cognitive performance was associated with gold standard paper and pencil tests. Results also showed an expected negative correlation with age, a relation with educational level as well as a gender effect. Regression-based norming equations for the sample tested are also reported. Performing a cognitive assessment with this digital solution is feasible and potentially useful to gather information about cognitive functioning in large samples and experimental settings.

Sibship Size, Height and Cohort Selection: A Methodological Approach.

This article deals with the historical relationship between the number of siblings in a family or household and height, a proxy for biological living standards. Ideally, this relationship is better assessed when we have evidence on the exact number of siblings in a family from its constitution onwards. However, this generally requires applying family reconstitution techniques, which, unfortunately, is not always possible. In this latter case, scholars must generally settle for considering only particular benchmark years using population censuses, from which family and household structures are derived. These data are then linked to the height data for the young males of the family or household. Height data are generally obtained from military records. In this matching process, several decisions have to be taken, which, in turn, are determined by source availability and the number of available observations. Using data from late 19th-century Catalonia, we explore whether the methodology used in matching population censuses and military records as described above might affect the relationship between sibship size and biological living standards and, if so, to what extent. We conclude that, while contextual factors cannot be neglected, the methodological decisions made in the initial steps of research also play a role in assessing this relationship.

Aging in the Digital Age: Using Technology to Increase the Reach of the Clinician Expert and Close the Gap Between Health Span and Life Span.

Age-related cognitive impairment (ARCI) has a profound impact on individuals, families, health care systems, and societies at large. Evidence suggests that ARCI is the consequence of underlying brain pathology. Therefore, efforts to minimize the impact of ARCI and thus closing the gap between health span and life span, which has widened in recent years, requires early detection and timely deployment of targeted, personalized interventions. Access to clinical experts is limited and technology screening and assessment methods are thus appealing. However, as traditionally implemented patients were deprived of the benefit of personalized connection with a clinician, which is particularly critical for the prescription and to ensure the adherence to and ultimate success of therapeutic interventions. We present the concept of Intelligent Technology Therapy Assistant (ITA) as a scalable solution that increases the reach of clinical experts while sustaining the personal connection between each patient and their clinician. We illustrate ITA with the "Guttman Neuro Personal Trainer"®, a tele-rehabilitation platform that provides neuropsychological evaluation and care, and the Barcelona Brain Health Initiative (BBHI) multimodal intervention coaching app, a mobile-based platform that provides lifestyle coaching support in domains related to brain health. In addition, we discuss the translation of these models to a large-scale enterprise with Linus Health. To this end, we conclude with a discussion of challenges and opportunities to move the field forward.

Intelligent Coaching Assistant for the Promotion of Healthy Habits in a Multidomain mHealth-Based Intervention for Brain Health.

Brain Health is defined as the development and preservation of optimal brain integrity and neural network functioning for a given age. Recent studies have related healthy habits with better maintenance of brain health across the lifespan. As a part of the Barcelona Brain Health Initiative (BBHI), a mHealth platform has been developed with the purpose of helping people to improve and monitor their healthy habits, facilitating the delivery of health coaching strategies. A decision support system (DSS), named Intelligent Coaching Assistant (ICA), has been developed to ease the work of professional brain health coaches, helping them design and monitor adherence to multidomain interventions in a more efficient manner. Personalized recommendations are based on users' current healthy habits, individual preferences, and motivational aspects. Taking these inputs, an initial user profile is defined, and the ICA applies an algorithm for determining the most suitable personalized intervention plan. An initial validation has been done focusing on assessing the feasibility and usability of the solution, involving 20 participants for three weeks. We conclude that this kind of technology-based intervention is feasible and implementable in real-world settings. Importantly, the personalized intervention proposal generated by the DSS is feasible and its acceptability and usability are high.

[Biological Standards of Living in Rural Catalonia over the Long Run: A Comparison with Urban Areas (1840-1960)]. / Niveles de vida biológicos en la Cataluña rural en el largo plazo: una comparación con las áreas urbanas (1840-1960).

OBJECTIVE: to assess the long-term evolution of biological living standards in rural Catalonia and to compare it with the corresponding figures in urban areas. METHODS: using data from military records of conscripts from six towns in western Catalonia, we construct an annual height series. Height is standardised at the age of 21 years. We also construct a body mass index (BMI) for conscripts born in 1891 and 1934-39. The annual height series for western Catalonia is systematically compared to the series for Reus, Catalonia's second largest city during the second half of the 19th century. RESULTS: comparing the cohorts born in the periods 1840-49 and 1951-60, we find that height increased by 5.7 centimetres over this period. However, the increase was not distributed equally over time. In the second half of the 19th century, rural heights stagnated over the long run and declined relative to urban heights. In the cohorts born in the decades between 1910 and 1950, rural heights rose by more than 5 centimetres, and converged with those of Reus. CONCLUSION: we provide new evidence for the current debate on the rural-urban height gap. Between the 1840s and the 1950s, heights in rural western Catalonia grew at rates similar to those recorded in certain urban areas, but growth rates differed depending on the period of analysis. This study underlines the importance of adopting long-term perspectives, and stresses that rural-urban height differences tend to be time-and space-specific.

Objetivo: analizar la evolución en el largo plazo del nivel de vida biológico en la Cataluña rural y explorar hasta qué punto esta fue diferente a la de las zonas urbanas. Métodos: utilizamos datos de los registros militares de seis localidades rurales del poniente catalán con los que construimos una serie anual de estatura estandarizada a la edad de 21 años con las cohortes nacidas entre 1840 y 1960. También elaboramos un IMC para los reclutas nacidos en 1891 y 1934-1939. La serie rural de estatura se compara sistemáticamente con la de Reus, el segundo mayor centro urbano catalán de la segunda mitad del siglo xix. Resultados: los datos muestran que la estatura aumentó 5,7 centímetros entre las cohortes nacidas entre 1840-1849 y 1951-1960, aunque desigualmente distribuidos a lo largo del tiempo. En la segunda mitad del siglo xix hubo estancamiento en el largo plazo y divergencia con las estaturas urbanas. Entre 1910 y 1950 la talla rural mejoró en más de 5 centímetros y terminó convergiendo con la de Reus. Conclusión: se aporta nueva evidencia al debate sobre la brecha rural-urbana en el nivel de vida biológico. En el periodo analizado, las tasas de crecimiento de la estatura fueron parecidas en ambos ámbitos, aunque con diferencias según el periodo de análisis. Este estudio subraya la importancia de adoptar perspectivas de largo plazo y señala que las diferencias de estatura rural-urbana tienden a ser específicas de tiempo y espacio.

[Nutrition, growth and inequality in the long term: What does anthropometric history teach about Spain?] / Nutrición y desigualdad en el largo plazo: ¿qué enseña la historia antropométrica sobre España?

This article underlines the relevance of anthropometric history among the disciplines concerned with health and nutrition. The examination of changes on the nutritional status and inequality in Spain focused the 4th Anthropometric History Workshop held at the beginning of 2018 where 18 original contributions were presented and discussed. We first show the ability of human stature to approach the impact of socioeconomic processes and environmental changes on the nutritional status over the last centuries. Then it is proceeded to present the main contents and advances achieved in the workshop. The papers coped with diverse dimensions of inequality regarding nutritional health and its determinants since the end of the 18th century until 2015. Aside of height and weight at different ages, principally adult ones, others anthropometric indicators were analyzed such as sexual dimorphism and low weight at birth. The results illustrate the large prevalence of malnutrition and social inequality in past Spain. These problems persisted over a good part of the 20th century (i.e. stunting) and, they acquired a different nature since the 1980s as the increasing prevalence of overweight and obesity reveals. It is concluded that the determinants of nutritional status and health-related inequalities request multidimensional approaches and the dialogue between social sciences and biomedical sciences. Knowing about their dimensions in the past and their evolution over time provides a valuable basis in order to understand current problems in these areas and to address future public policies more adequately on childhood and adolescence.

Este artículo destaca la importancia de la historia antropométrica entre las ciencias preocupadas por la nutrición y la salud. La evolución del estado nutricional y de la desigualdad en España medida por indicadores antropométricos es el principal objetivo de un conjunto de 18 contribuciones presentadas y discutidas en el IV Workshop de Historia Antropométrica celebrado a comienzos de 2018.Después de mostrar la capacidad de la estatura humana como representación del impacto de los procesos socioeconómicos y de los cambios ambientales en el estado nutricional durante los últimos siglos, se presentan las principales aportaciones y avances realizados en el taller. Las contribuciones abordan distintas facetas de la desigualdad de la salud nutricional y de sus determinantes desde finales del siglo XVIII hasta 2015. Además de la talla y del peso a diferentes edades (principalmente adultas), se incluyen otros indicadores antropométricos, como el dimorfismo sexual y el bajo peso al nacimiento. Los resultados reflejan graves problemas de malnutrición y de desigualdad en el pasado que persisten con otra naturaleza en la actualidad: retraso en el crecimiento hasta la década de los sesenta y creciente prevalencia de obesidad desde 1980.Se concluye que los determinantes del estado nutricional y de la desigualdad de la salud requieren un enfoque multidimensional y de diálogo entre las ciencias sociales y las biomédicas. Conocer su dimensión en el pasado y su evolución proporciona un valioso aporte de conocimiento para entender con mayor perspectiva los problemas actuales y poder intervenir con atino en las políticas futuras.

Geological characterization of the Prestige sinking area.

The tanker Prestige sank off NW Iberia on the 19th November 2002. The stern and bow of the Prestige wreck are located on the southwestern edge of the Galicia Bank, at 3565 m and 3830 m water depths, respectively. This bank is a structural high controlled by major faults with predominant N-S, NNE-SSW, and NNW-SEE trends. It is characterized by moderate to low seismic activity. The faults have controlled the local depositional architecture, deforming, fracturing, relocating and distributing sediments since the Valangian (early Cretaceous). The Prestige sinking area corresponds to an asymmetric half-graben structure with a N-S trend, which conditions the present-day morphology. The faulted flank outcrops and its activity and erosion have favoured the occurrence of mass-movements (slumps, slump debris, mass-flows and turbidity currents), building valleys and depositional lobes. Nearsurface sediments comprise mostly terrigenous and biogenous turbiditic muds and sands with a minor presence of hemipelagic muds, except on the fault scarp where pelagites predominate. Potential geological hazards resulting from tectonic and sedimentary processes affect almost the entire Prestige sinking area.

Biological Standards of Living in Rural Catalonia over the Long Run: A Comparison with Urban Areas (1840-1960) / Niveles de vida biológicos en la Cataluña rural en el largo plazo: una comparación con las áreas urbanas (1840-1960)

Objective: to assess the long-term evolution of biological living standards in rural Catalonia and to compare it with the corresponding figures in urban areas. Methods: using data from military records of conscripts from six towns in western Catalonia, we construct an annual height series. Height is standardised at the age of 21 years. We also construct a body mass index (BMI) for conscripts born in 1891 and 1934-39. The annual height series for western Catalonia is systematically compared to the series for Reus, Catalonia’s second largest city during the second half of the 19th century. Results: comparing the cohorts born in the periods 1840-49 and 1951-60, we find that height increased by 5.7 centimetres over this period. However, the increase was not distributed equally over time. In the second half of the 19th century, rural heights stagnated over the long run and declined relative to urban heights. In the cohorts born in the decades between 1910 and 1950, rural heights rose by more than 5 centimetres, and converged with those of Reus. Conclusion: we provide new evidence for the current debate on the rural-urban height gap. Between the 1840s and the 1950s, heights in rural western Catalonia grew at rates similar to those recorded in certain urban areas, but growth rates differed depending on the period of analysis. This study underlines the importance of adopting long-term perspectives, and stresses that rural-urban height differences tend to be time-and space-specific

Objetivo: analizar la evolución en el largo plazo del nivel de vida biológico en la Cataluña rural y explorar hasta qué punto esta fue diferente a la de las zonas urbanas. Métodos: utilizamos datos de los registros militares de seis localidades rurales del poniente catalán con los que construimos una serie anual de estatura estandarizada a la edad de 21 años con las cohortes nacidas entre 1840 y 1960. También elaboramos un IMC para los reclutas nacidos en 1891 y 1934-1939. La serie rural de estatura se compara sistemáticamente con la de Reus, el segundo mayor centro urbano catalán de la segunda mitad del siglo xix. Resultados: los datos muestran que la estatura aumentó 5,7 centímetros entre las cohortes nacidas entre 1840-1849 y 1951-1960, aunque desigualmente distribuidos a lo largo del tiempo. En la segunda mitad del siglo xix hubo estancamiento en el largo plazo y divergencia con las estaturas urbanas. Entre 1910 y 1950 la talla rural mejoró en más de 5 centímetros y terminó convergiendo con la de Reus. Conclusión: se aporta nueva evidencia al debate sobre la brecha rural-urbana en el nivel de vida biológico. En el periodo analizado, las tasas de crecimiento de la estatura fueron parecidas en ambos ámbitos, aunque con diferencias según el periodo de análisis. Este estudio subraya la importancia de adoptar perspectivas de largo plazo y señala que las diferencias de estatura rural-urbana tienden a ser específicas de tiempo y espacio

Nutrición y desigualdad en el largo plazo: ¿qué enseña la historia antropométrica sobre España? / Nutrition, growth and inequality in the long term: What does anthropometric history teach about Spain?

Este artículo destaca la importancia de la historia antropométrica entre las ciencias preocupadas por la nutrición y la salud. La evolución del estado nutricional y de la desigualdad en España medida por indicadores antropométricos es el principal objetivo de un conjunto de 18 contribuciones presentadas y discutidas en el IV Workshop de Historia Antropométrica celebrado a comienzos de 2018. Después de mostrar la capacidad de la estatura humana como representación del impacto de los procesos socioeconómicos y de los cambios ambientales en el estado nutricional durante los últimos siglos, se presentan las principales aportaciones y avances realizados en el taller. Las contribuciones abordan distintas facetas de la desigualdad de la salud nutricional y de sus determinantes desde finales del siglo xviii hasta 2015. Además de la talla y del peso a diferentes edades (principalmente adultas), se incluyen otros indicadores antropométricos, como el dimorfismo sexual y el bajo peso al nacimiento. Los resultados reflejan graves problemas de malnutrición y de desigualdad en el pasado que persisten con otra naturaleza en la actualidad: retraso en el crecimiento hasta la década de los sesenta y creciente prevalencia de obesidad desde 1980. Se concluye que los determinantes del estado nutricional y de la desigualdad de la salud requieren un enfoque multidimensional y de diálogo entre las ciencias sociales y las biomédicas. Conocer su dimensión en el pasado y su evolución proporciona un valioso aporte de conocimiento para entender con mayor perspectiva los problemas actuales y poder intervenir con atino en las políticas futuras

This article underlines the relevance of anthropometric history among the disciplines concerned with health and nutrition. The examination of changes on the nutritional status and inequality in Spain focused the 4th Anthropometric History Workshop held at the beginning of 2018 where 18 original contributions were presented and discussed. We first show the ability of human stature to approach the impact of socioeconomic processes and environmental changes on the nutritional status over the last centuries. Then it is proceeded to present the main contents and advances achieved in the workshop. The papers coped with diverse dimensions of inequality regarding nutritional health and its determinants since the end of the 18th century until 2015. Aside of height and weight at different ages, principally adult ones, others anthropometric indicators were analyzed such as sexual dimorphism and low weight at birth. The results illustrate the large prevalence of malnutrition and social inequality in past Spain. These problems persisted over a good part of the 20th century (i.e. stunting) and, they acquired a different nature since the 1980s as the increasing prevalence of overweight and obesity reveals. It is concluded that the determinants of nutritional status and health-related inequalities request multidimensional approaches and the dialogue between social sciences and biomedical sciences. Knowing about their dimensions in the past and their evolution over time provides a valuable basis in order to understand current problems in these areas and to address future public policies more adequately on childhood and adolescence