[Magnetic foreign bodies of the gastrointestinal tract in pediatric practice]. / Magnitnye inorodnye tela zheludochno-kishechnogo trakta v pediatricheskoi praktike.

OBJECTIVE: To analyze the pediatric patients with multiple magnetic foreign bodies of the gastrointestinal tract undergoing surgical intervention; to present the treatment and diagnostic algorithm in pediatric practice; to compare surgical interventions for these lesions and determine the most optimal one. MATERIAL AND METHODS: A retrospective single-center study included 9 patients diagnosed with multiple magnetic foreign bodies of the gastrointestinal tract. Exclusion criteria: outpatient cases and endoscopic removal of magnetic foreign bodies. All patients underwent laparoscopy and/or laparotomy. We analyzed postoperative data and determined the preferable approach. RESULTS: All patients were discharged without complications. Length of hospital-stay was shorter after laparoscopy (7 vs. 12 days). Patients after laparoscopy didn't need for intensive care while laparotomy required ICU stay for 4.5±2.2 days. Enteral feeding started after 1 and 3 days, respectively. CONCLUSION: Laparoscopy is preferable for multiple magnetic foreign bodies of the gastrointestinal tract due to shorter hospital-stay, no need for ICU-stay, lower surgical trauma and earlier enteral feeding.

Measurement of 24-h continuous human CH4 release in a whole room indirect calorimeter.

We describe the technology and validation of a new whole room indirect calorimeter (WRIC) methodology to quantify volume of methane (VCH4) released from the human body over 24 h concurrently with the assessment of energy expenditure and substrate utilization. The new system extends the assessment of energy metabolism by adding CH4, a downstream product of microbiome fermentation that could contribute to energy balance. Our new system consists of an established WRIC combined with the addition of off-axis integrated-cavity output spectroscopy (OA-ICOS) to measure CH4 concentration ([CH4]). Development, validation, and reliability of the system included environmental experiments to measure the stability of the atmospheric [CH4], infusing CH4 into the WRIC and human cross-validation studies comparing [CH4] quantified by OA-ICOS and mid-infrared dual-comb spectroscopy (MIR DCS).Our infusion data indicated that the system measured 24-h [CH4] and VCH4 with high sensitivity, reliability, and validity. Cross-validation studies showed good agreement between OA-ICOS and MIR DCS technologies (r = 0.979, P < 0.0001). Human data revealed 24-h VCH4 was highly variable between subjects and within/between days. Finally, our method to quantify VCH4 released by breath or colon suggested that over 50% of the CH4 was eliminated through the breath. The method allows, for the first time, measurement of 24-h VCH4 (in kcal) and therefore the measurement of the proportion of human energy intake fermented to CH4 by the gut microbiome and released via breath or from the intestine; also, it allows us to track the effects of dietary, probiotic, bacterial, and fecal microbiota transplantation on VCH4.NEW & NOTEWORTHY This is the first time that continuous assessment of CH4 is reported in parallel with measurements of O2 consumption and CO2 production inside a whole room indirect calorimeter in humans and over 24 h. We provide a detailed description of the whole system and its parts. We carried out studies of reliability and validity of the whole system and its parts. CH4 is released in humans during daily activities.

Vacuum breakdown in magnetic dipole wave by 10-PW class lasers.

The vacuum breakdown by 10-PW-class lasers is studied in the optimal configuration of laser beams in the form of an m-dipole wave, which maximizes the magnetic field. Using 3D PIC simulations we calculated the threshold of vacuum breakdown, which is about 10 PW. We examined in detail the dynamics of particles and identified particle trajectories which contribute the most to vacuum breakdown in such highly inhomogeneous fields. We analyzed the dynamics of the electron-positron plasma distribution on the avalanche stage. It is shown that the forming plasma structures represent concentric toroidal layers and the interplay between particle ensembles from different spatial regions favors vacuum breakdown. Based on the angular distribution of charged particles and gamma photons a way to experimentally identify the process of vacuum breakdown is proposed.

Particle trajectories, gamma-ray emission, and anomalous radiative trapping effects in magnetic dipole wave.

In studies of interaction of matter with laser fields of extreme intensity there are two limiting cases of a multibeam setup maximizing either the electric field or the magnetic field. In this work attention is paid to the optimal configuration of laser beams in the form of an m-dipole wave, which maximizes the magnetic field. We consider in such highly inhomogeneous fields the advantages and specific features of laser-matter interaction, which stem from individual particle trajectories that are strongly affected by gamma photon emission. It is shown that in this field mode qualitatively different scenarios of particle dynamics take place in comparison with the mode that maximizes the electric field. A detailed map of possible regimes of particle motion (ponderomotive trapping, normal radiative trapping, radial, and axial anomalous radiative trapping), as well as angular and energy distributions of particles and gamma photons, is obtained in a wide range of laser powers up to 300 PW, and it reveals signatures of radiation losses experimentally detectable even with subpetawatt lasers.

Particle dynamics governed by radiation losses in extreme-field current sheets.

Particles moving in current sheets under extreme conditions, such as those in the vicinity of pulsars or those predicted on upcoming multipetawatt laser facilities, may be subject to significant radiation losses. We present an analysis of particle motion in model fields of a relativistic neutral electron-positron current sheet in the case when radiative effects must be accounted for. In the Landau-Lifshitz radiation reaction force model, when quantum effects are negligible, an analytical solution for particle trajectories is derived. Based on this solution, for the case when quantum effects are significant an averaged quantum solution in the semiclassical approach is obtained. The applicability region of the solutions is determined and analytical trajectories are found to be in good agreement with those of numerical simulations which account for radiative effects. Based on these results we demonstrate that radiation reaction itself can provide a mechanism of pinching even within a given field consideration.

Broadband high-resolution molecular spectroscopy with interleaved mid-infrared frequency combs.

Traditionally, there has been a trade-off in spectroscopic measurements between high resolution, broadband coverage, and acquisition time. Originally envisioned for precision spectroscopy of the hydrogen atom in the ultraviolet, optical frequency combs are now commonly used for probing molecular ro-vibrational transitions throughout broad spectral bands in the mid-infrared providing superior resolution, speed, and the capability of referencing to the primary frequency standards. Here we demonstrate the acquisition of 2.5 million spectral data points over the continuous wavelength range of 3.17-5.13 µm (frequency span 1200 cm-1, sampling point spacing 13-21 MHz), via interleaving comb-tooth-resolved spectra acquired with a highly-coherent broadband dual-frequency-comb system based on optical subharmonic generation. With the original comb-line spacing of 115 MHz, overlaying eight spectra with gradually shifted comb lines we fully resolve the amplitude and phase spectra of molecules with narrow Doppler lines, such as carbon disulfide (CS2) and its three isotopologues.

Laser-driven plasma pinching in e

The cascaded production and dynamics of electron-positron plasma in ultimately focused laser fields of extreme intensity are studied by three-dimensional particle-in-cell simulations with the account of the relevant processes of quantum electrodynamics (QED). We show that, if the laser facility provides a total power above 20 PW, it is possible to trigger not only a QED cascade but also pinching in the produced electron-positron plasma. The plasma self-compression in this case leads to an abrupt rise of the peak density and magnetic (electric) field up to at least 10^{28}cm^{-3} and 1/20 (1/40) of the Schwinger field, respectively. Determining the actual limits and physics of this process might require quantum treatment beyond the used standard semiclassical approach. The proposed setup can thus provide extreme conditions for probing and exploring fundamental physics of the matter and vacuum.

Extended particle-in-cell schemes for physics in ultrastrong laser fields: Review and developments.

We review common extensions of particle-in-cell (PIC) schemes which account for strong field phenomena in laser-plasma interactions. After describing the physical processes of interest and their numerical implementation, we provide solutions for several associated methodological and algorithmic problems. We propose a modified event generator that precisely models the entire spectrum of incoherent particle emission without any low-energy cutoff, and which imposes close to the weakest possible demands on the numerical time step. Based on this, we also develop an adaptive event generator that subdivides the time step for locally resolving QED events, allowing for efficient simulation of cascades. Further, we present a unified technical interface for including the processes of interest in different PIC implementations. Two PIC codes which support this interface, PICADOR and ELMIS, are also briefly reviewed.