RESUMEN
The effects of composite fibroin-gelatin microparticles (100-250 µ) on the rate of wound healing and regeneration under conditions of contraction prevention were studied on the model of splinted full-thickness skin wound in a mouse. Subcutaneous injection of these particles into the defect area accelerated wound healing and promoted re-epithelialization and recovery of normal structure of the epidermis. In addition, the composite microparticles promoted the formation of connective tissue of characteristic structure, replacing the derma over the entire defect, and stimulated regeneration of subcutaneous muscle (panniculus carnosus) and skin appendages (sebaceous glands and hair follicles).
Asunto(s)
Fibroínas/química , Fibroínas/farmacología , Gelatina/química , Gelatina/farmacología , Enfermedades de la Piel/tratamiento farmacológico , Piel/metabolismo , Animales , Masculino , Ratones , Ratones Endogámicos C57BL , Regeneración/efectos de los fármacos , Piel/efectos de los fármacos , Cicatrización de Heridas/efectos de los fármacosRESUMEN
The distribution of ABO blood groups and rhesus factor was studied in patients with myasthenia as compared with the control. There was a statistically significant association of the diseases with the rhesus-negative phenotype and that of generalized myasthenia concurrent with thymoma with the B (III) blood group. The examination revealed no other determinants of the significant association with the disease. The values of a disease risk were obtained for persons having myasthenia-associated signs. It is concluded that the Rh-negative phenotype shows a 1.3-fold increase in the risk of the disease as compared with those having Rh-positive persons.
Asunto(s)
Sistema del Grupo Sanguíneo ABO , Miastenia Gravis/sangre , Sistema del Grupo Sanguíneo Rh-Hr , Humanos , Modelos Teóricos , Miastenia Gravis/etiología , Fenotipo , Factores de RiesgoRESUMEN
The authors describe the course of myasthenia in children whose mean age of the disease onset is 10.1 years (7.9 years in boys and 11.2 years in girls). All the children had generalized myasthenia. The use of plasmapheresis produced a beneficial effect in all the cases, especially in children with grave myasthenia.
Asunto(s)
Hipotonía Muscular/diagnóstico , Miastenia Gravis/diagnóstico , Oftalmoplejía/diagnóstico , Plasmaféresis , Insuficiencia Respiratoria/diagnóstico , Adolescente , Niño , Terapia Combinada , Diagnóstico Diferencial , Femenino , Humanos , Masculino , Hipotonía Muscular/etiología , Hipotonía Muscular/terapia , Miastenia Gravis/complicaciones , Miastenia Gravis/terapia , Oftalmoplejía/etiología , Oftalmoplejía/terapia , Insuficiencia Respiratoria/etiología , Insuficiencia Respiratoria/terapiaRESUMEN
The article deals with the experience in the treatment of 220 children with generalized forms of purulent peritonitis of various origin (appendicular, posttraumatic, consequence of destructive pancreatitis and other inflammatory processes in the abdominal cavity). A scheme of therapeutic measures which were applied for the control of infection and endotoxicosis is given. They include homeostasis by means of extracorporeal detoxification, differentiated immunocorrection, quantum therapy, and other modern methods of treatment. Mortality among the patients was 5.9%, while before the introduction of the described methods into practice it was 13.2%.
Asunto(s)
Peritonitis/terapia , Desintoxicación por Sorción/métodos , Niño , Terapia Combinada , Homeostasis , Humanos , Masculino , Peritonitis/etiología , Peritonitis/mortalidad , Peritonitis/patología , Peritonitis/fisiopatología , Cuidados Preoperatorios , Reoperación , Supuración , Procedimientos Quirúrgicos Operativos/métodos , Tasa de Supervivencia , Resultado del TratamientoAsunto(s)
Plasmaféresis , Sepsis/terapia , Formación de Anticuerpos/inmunología , Hemodinámica/fisiología , Humanos , Inmunidad Celular/inmunología , Inmunoglobulina G/inmunología , Inmunoglobulina M/inmunología , Recién Nacido , Monitoreo Fisiológico , Plasmaféresis/efectos adversos , Plasmaféresis/instrumentación , Plasmaféresis/métodos , Sepsis/inmunología , Sepsis/fisiopatología , Síndrome , Resultado del TratamientoRESUMEN
Thymectomy was carried out in 52 children with the generalized form of myasthenia at the Moscow Regional Research Clinical Institute in 1986-1991. The long-term results were studied in 50 patients in follow-up periods of 6 months to 5 years. The follow-up was studied in all patients, the muscular strength in various groups of muscles was measured according to a 5-point scale, and the function of external respiration, neuromuscular conductivity, and cellular and humoral immunity were studied. After thymectomy the symptoms of myasthenia disappeared completely or diminished significantly, the decrement was 11% on the average instead of 37% as was before the operation, the external respiration values improved, the level of circulating immune complexes and immunoglobulins became normal. The long-term results were appraised according to G. Keanes' scale. Group A was made up of 22 patients, group B of 13, group C of 5, group D of 8, and group E of 2 patients. Thus, the study shows that thymectomy is the most effective method for the treatment of myasthenia in children today.
Asunto(s)
Miastenia Gravis/cirugía , Plasmaféresis , Timectomía , Adolescente , Niño , Femenino , Estudios de Seguimiento , Humanos , Masculino , Miastenia Gravis/fisiopatología , Unión Neuromuscular/fisiología , Cuidados Posoperatorios , Cuidados Preoperatorios , Respiración/fisiología , Transmisión Sináptica/fisiología , Factores de TiempoRESUMEN
HLA-phenotype was determined in 59 juvenile patients of Russian nationality and in their 50 relatives by means of lymphocytotoxic test. There was a positive association with HLA-A1, B8 and DR3 and the negative one--with HLA-A2, A9, B5, B7, and DR7. The frequencies of HLA-A1, B8, DR3 were higher in boys than in girls with myasthenia. There were no significant changes of HLA frequencies in ocular form of the disease in comparison with the healthy group. The frequencies of HLA-B8 and DR3 were significantly higher in relatives of the patients with juvenile myasthenia than in control population.
Asunto(s)
Antígenos HLA-DR/inmunología , Miastenia Gravis/inmunología , Niño , Femenino , Humanos , Masculino , Modelos Biológicos , Miastenia Gravis/fisiopatología , Fenotipo , Timo/inmunología , Timo/fisiopatologíaRESUMEN
Twin pairs with one or two myasthenic patients were selected from patients with neuromuscular pathology. 18 couples of twins were included in final selection (9 monozygotic and 9 dizygotic pairs). 4 pairs of monozygotic twins were concordant to myasthenia (MA). All dizygotic pairs were discordant to this disease. Matched concordance of monozygotic twins was 44%. Penetration of pathological gene was 61% assuming the hypothesis about monogenic heredity of MA. The coefficient of heredity was 44%. The conclusion was made about important, but not absolute role of hereditary factors in development of MA. It was necessary the presence of combination of both genetic and environmental factors for MA development.
Asunto(s)
Enfermedades Autoinmunes/genética , Miastenia Gravis/genética , Adolescente , Adulto , Anciano , Enfermedades Autoinmunes/etiología , Femenino , Frecuencia de los Genes , Humanos , Masculino , Persona de Mediana Edad , Miastenia Gravis/etiología , Linaje , Federación de Rusia , Encuestas y Cuestionarios , Gemelos Dicigóticos , Gemelos MonocigóticosRESUMEN
Thymectomy was included in the complex of therapeutic measures in the management of generalized myasthenia in 41 children. Much attention was given to preoperative management in which plasmapheresis was applied along with the traditional methods. As a result, maximum compensation of the myasthenic disorders was achieved and spontaneous respiration was restored in 9 patients who were given artificial ventilation of the lungs before the operation. The authors describe the techniques of thymectomy and the changes found in the thymus during histological study. No complications occurred. All of the children were discharged from the clinic in an improved condition. The late-term results were studied in 38 children in follow-up periods of 6 months to 4 years. Marked stable improvement was recorded in 31 (77.5%) patients.