RESUMEN
The synthesis of two series of 4'-aza-carbocyclic nucleosides are described in which the 4'-substituent is either a reversed amide, relative to the carboxamide of NECA, or an N-bonded heterocycle. Using established purine substitution patterns, potent and selective examples of agonists of the human adenosine A(2A) receptor have been identified from both series. The propionamides 14-18 and the 4-hydroxymethylpyrazole 32 were determined to be the most potent and selective examples from the 4'-reversed amide and 4'-N-bonded heterocyclic series, respectively.
Asunto(s)
Agonistas del Receptor de Adenosina A2 , Compuestos Aza/síntesis química , Ácidos Carboxílicos/síntesis química , Nucleósidos/síntesis química , Nucleótidos de Pirimidina/síntesis química , Animales , Compuestos Aza/metabolismo , Compuestos Aza/farmacología , Células CHO , Ácidos Carboxílicos/metabolismo , Ácidos Carboxílicos/farmacología , Cricetinae , Cricetulus , Evaluación Preclínica de Medicamentos/métodos , Humanos , Nucleósidos/metabolismo , Nucleósidos/farmacología , Nucleótidos de Pirimidina/metabolismo , Nucleótidos de Pirimidina/farmacología , Ratas , Receptor de Adenosina A2A/metabolismoRESUMEN
The technology behind a large area array of flexible solar cells with a unique design and semitransparent blue appearance is presented. These modules are implemented in a solar tree installation at the German pavilion in the EXPO2015 in Milan/IT. The modules show power conversion efficiencies of 4.5% and are produced exclusively using standard printing techniques for large-scale production.
RESUMEN
Organotin impurities in product mixtures can be reduced from stoichiometric levels to approximately 15 parts per million by column chromatography using 10% w/w anhydrous potassium carbonate-silica as a stationary phase.