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BACKGROUND: Economic evaluation is assuming increasing importance as an integral component of health services research. AIM: To conduct a systematic review of the literature and assess the evidence from studies presenting orthodontic treatment outcomes and the related costs. MATERIALS/METHODS: The literature review was conducted in four steps, according to Goodman's model, in order to identify all studies evaluating economic aspects of orthodontic interventions. The search covered the databases Medline, Cinahl, Cochrane, Embase, Google Scholar, National Health Service Economic Evaluation Database, and SCOPUS, for the period from 1966 to September 2014. The inclusion criteria were as follows: randomized controlled trials or controlled clinical trials comparing at least two different orthodontic interventions, evaluation of both economic and orthodontic outcomes, and study populations of all ages. The quality of each included study was assessed as limited, moderate, or high. The overall evidence was assessed according to the GRADE system (The Grading of Recommendations Assessment, Development and Evaluation). RESULTS: The applied terms for searches yielded 1838 studies, of which 989 were excluded as duplicates. Application of the inclusion and exclusion criteria identified 26 eligible studies for which the full-text versions were retrieved and scrutinized. At the final analysis, eight studies remained. Three studies were based on cost-effectiveness analyses and the other five on cost-minimization analysis. Two of the cost-minimization studies included a societal perspective, i.e. the sum of direct and indirect costs. The aims of most of the studies varied widely and of studies comparing equivalent treatment methods, few were of sufficiently high study quality. Thus, the literature to date provides an inadequate evidence base for economic aspects of orthodontic treatment. CONCLUSION: This systematic review disclosed that few orthodontic studies have presented both economic and clinical outcomes. There is currently insufficient evidence available about the health economics of orthodontic interventions. Further investigation is warranted.
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Costos de la Atención en Salud/estadística & datos numéricos , Ortodoncia/economía , Análisis Costo-Beneficio , Medicina Basada en la Evidencia/métodos , Humanos , Ortodoncia Correctiva/economía , Resultado del TratamientoRESUMEN
OBJECTIVE: Economic evaluations provide an important basis for allocation of resources and health services planning. The aim of this study was to evaluate and compare the costs of correcting anterior crossbite with functional shift, using fixed or removable appliances (FA or RA) and to relate the costs to the effects, using cost-minimization analysis. DESIGN, SETTING, AND PARTICIPANTS: Sixty-two patients with anterior crossbite and functional shift were randomized in blocks of 10. Thirty-one patients were randomized to be treated with brackets and arch wire (FA) and 31 with an acrylic plate (RA). Duration of treatment and number and estimated length of appointments and cancellations were registered. Direct costs (premises, staff salaries, material, and laboratory costs) and indirect costs (the accompanying parents' loss of income while absent from work) were calculated and evaluated with reference to successful outcome alone, to successful and unsuccessful outcomes and to re-treatment when required. Societal costs were defined as the sum of direct and indirect costs. INTERVENTIONS: Treatment with FA or RA. RESULTS: There were no significant differences between FA and RA with respect to direct costs for treatment time, but both indirect costs and direct costs for material were significantly lower for FA. The total societal costs were lower for FA than for RA. LIMITATIONS: Costs depend on local factors and should not be directly extrapolated to other locations. CONCLUSION: The analysis disclosed significant economic benefits for FA over RA. Even when only successful outcomes were assessed, treatment with RA was more expensive. TRIAL REGISTRATION: This trial was not registered. PROTOCOL: The protocol was not published before trial commencement.
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Maloclusión/terapia , Diseño de Aparato Ortodóncico/economía , Aparatos Ortodóncicos/economía , Citas y Horarios , Niño , Costo de Enfermedad , Costos y Análisis de Costo , Costos Directos de Servicios , Femenino , Estudios de Seguimiento , Humanos , Renta , Masculino , Maloclusión/economía , Aparatos Ortodóncicos Removibles/economía , Soportes Ortodóncicos/economía , Alambres para Ortodoncia/economía , Retratamiento , Factores de Tiempo , Resultado del TratamientoRESUMEN
At a national level, planning and management of dental services should be based on assess- ments of equity, effectiveness and costs. In Sweden, data for the adult population are now acces- sible through The Swedish dental health register, at The National Board of Health and Welfare. This study, on two large cohorts of Swedish adults, is based on longitudinal follow-up data, retrieved from the Swedish dental health register.The aims were twofold: to assess frequencies and costs of fillings and crowns, including subsequent repair; secondly to study the relationship between preventive and restorative dental treatment.The Swedish dental health register pro- vides data on the adult population which offers a new perspective on public health aspects of management of dental care at the national level. A longitudinal, prospective study model was used to follow-up two large cohorts for over four years. In the first cohort, data on 1,088,923 adult patients were analysed with reference to provision of single crowns and fillings over a period of 42 -48 months.The second cohort comprised 1,703,147 adult patients: the data were analysed with reference to preventive interventions over a period of 48 - 54 months. Frequencies of distribution of dental care by age group showed that the cohorts were representative for the whole patient group.With respect to equity, the average number of dentist appointments per i,ooo inhabitants for all 21 regions of Sweden was 140 to 160, despite major variations in geographic conditions and population densities. With respect to effectiveness, about 76% of the teeth with index interven- tions required no additional intervention over four consecutive years of follow-up. For the remain- ing 24% of the teeth 77% had only one additional intervention. When differences of case-mix were taken into account, the costs of repairs to earlier ihterventions were basically similar, regardless of age-group.There were no gender differences. However, there were pronounced differences, of up to three intact teeth, among patients from different regions of Sweden. Follow-up of effects of caries prevention showed no gender differences. However, costs for reparative interventions increased with higher costs for preventive treatment. Moreover, the longer the interval between preventive interventions, the lower the costs for reparative interventions.The national dental health register is a potentially valuable source of data for dental research. In this study, longitu- dinal registry data on restorative and preventive treatment were retrieved and analysed, with reference to efficacy, costs and equity. The results have potential application in improving mana- gement of public dental health.
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INTRODUCTION: Multiple sclerosis (MS) is associated with reduced work capacity, but there is limited knowledge about MS patients' sources of income. OBJECTIVES: The purpose of this study was to elucidate MS patients' earnings and social benefits compared to those of the general population. METHODS: From nationwide registers of all residents in Sweden aged 21-64 years in 2010 (n=5,291,764), those with an MS diagnosis (n=13,979) were compared to a propensity score matched reference group (n=69,895). Descriptive statistics and regression models were used to estimate the percentage difference between the MS patients and the matched references regarding the following annual incomes: earnings, disability pension, sickness absence, disability allowance, unemployment compensation and social assistance. RESULTS: Both MS patients and the matched references received most of their income from earnings followed by disability pension and sickness absence. MS patients that were diagnosed in 2010 had 15% lower earnings than the matched references, while MS patients diagnosed before 2005 had 38% lower earnings. Corresponding figures regarding summed social benefits were 33% and 130% higher for MS patients, respectively. CONCLUSION: The results indicate that MS patients are overrepresented, in relative and absolute terms, regarding health-related benefits and have lower levels of earnings. However, the redistributing welfare systems appear to financially compensate the MS patients considerably.
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Renta , Esclerosis Múltiple/economía , Seguridad Social , Adulto , Personas con Discapacidad , Femenino , Humanos , Masculino , Persona de Mediana Edad , Pensiones , Sistema de Registros , Salarios y Beneficios , Suecia , Desempleo , Adulto JovenRESUMEN
OBJECTIVE: To assess the diagnostic accuracy of adjunct methods used to detect and quantify dental caries. STUDY DESIGN: A systematic literature search for relevant papers was conducted with pre-determined inclusion and exclusion criteria. Abstracts and full text articles were assessed independently by two reviewers. The study characteristics were compiled in tables and quality graded according to the QUADAS tool. The level of evidence for each diagnostic technology (fiber-optic methods, fluorescence methods, electrical methods) was based on studies of high or moderate quality according to the GRADE approach. RESULTS: Twenty-five reports fulfilled the inclusion criteria. One study was of high quality, 10 were graded as moderate, while the remaining 14 reports were of low quality. Electrical methods (ECM) and laser fluorescence (DIAGNOdent) displayed sensitivities and specificities around 70-80% regarding occlusal dentin lesions with a mean Youden's index of 0.52-0.54. The mean accuracy of laser fluorescence for detecting enamel and dentin lesions was 0.68 and 0.91, respectively. The heterogeneity of the published reports hampered the analysis. CONCLUSIONS: There was insufficient scientific evidence for diagnostic accuracy regarding fiber-optic methods and quantitative light-induced fluorescence (+OOO). The electrical methods and laser fluorescence could be useful adjuncts to visual-tactile and radiographic examinations, especially on occlusal surfaces in permanent and primary molars, but evidence was graded as limited (++OO). No conclusions could be drawn regarding the cost-effectiveness of the methods. There is an obvious need to standardize study designs for in vitro and in vivo validation of the different methods.
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Caries Dental/diagnóstico , Fluorescencia , Humanos , Sensibilidad y EspecificidadRESUMEN
OBJECTIVE: To conduct a systematic review and meta-synthesis of qualitative studies addressing patients' perceptions of loss of teeth, edentulism and oral rehabilitation. BACKGROUND: Qualitative studies can complement quantitative studies by achieving deep understanding of patients' subjective experiences of losing teeth and coping with edentulism. They can also explore the perception that the benefits of prosthetic rehabilitation extend far beyond primary clinical treatment goals of restoration of oral function. MATERIALS AND METHODS: The major data bases were searched extensively for relevant qualitative and quantitative studies, followed by manual searching of the reference lists of included publications. Two authors independently read all abstracts. Relevant papers were retrieved in full-text and included or excluded according to a specially designed protocol. The included articles were then appraised and rated for quality: high, moderate or low. Articles of low quality were excluded. RESULTS: The database search yielded 36 abstracts of qualitative studies; manual search disclosed one further article. All were read in full-text by two independent authors: 28 were excluded. Of the remaining nine, two (assessed as of low quality) were excluded for further analysis. Meta-synthesis, based on seven studies, disclosed two major themes: loss of quality-of-life associated with losing teeth and restored quality-of-life after oral rehabilitation. CONCLUSIONS: In this relatively new field of research, there are few published papers. Nevertheless, the studies to date show that loss of teeth is associated not only with compromised oral function, but also loss of social status and diminished self-esteem. Oral rehabilitation has broad positive implications, restoring quality of life and self-worth.
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Prótesis Dental , Boca Edéntula/psicología , Pérdida de Diente/psicología , HumanosRESUMEN
BACKGROUND: This systematic review assesses the effect of methods commonly used to manage the pulp in cases of deep caries lesions, and the extent the pulp chamber remains uninfected and does not cause pulpal or periapical inflammatory lesions and associated tooth-ache over time. STUDY DESIGN: An electronic literature search included the databases PubMed, EMBASE, The Cochrane Central Register of Controlled Trials and Cochrane Reviews from January 1950 to March 2013. In addition, hand searches were carried out. Two reviewers independently evaluated abstracts and full-text articles. An article was read in full if at least one of the two reviewers considered the abstract potentially relevant. Altogether, 161 articles were read in full text. Of these, 24 studies fulfilled established inclusion criteria. Based on studies of at least moderate quality, the quality of evidence of each procedure was rated in four levels according to GRADE. RESULTS: No study reached the high quality level. Twelve were of moderate quality. The overall evidence was insufficient to assess which of indirect pulp capping, stepwise excavation, direct excavation and pulp capping/partial pulpotomy, pulpotomy or pulpectomy is the most effective treatment approach for teeth with deep caries. CONCLUSIONS: Because of the lack of good studies it is not possible to determine whether an injured pulp by deep caries can be maintained or whether it should be removed and replaced with a root canal filling. Both randomized studies and prospective observational studies are needed to investigate whether a pulp exposed to deep caries is best treated by measures intended to preserve it or by pulpectomy and root filling.
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Caries Dental , Pulpa Dental , Tratamiento Restaurativo Atraumático Dental , Caries Dental/terapia , Recubrimiento de la Pulpa Dental , Humanos , Estudios Prospectivos , Materiales de Recubrimiento Pulpar y Pulpectomía , Pulpotomía , Caries RadicularRESUMEN
This study comprises a survey of Swedish dentists'treatment preferences in cases of carious exposure of the dental pulp in adults.The survey was conducted as part of a comprehensive report on methods of diagnosis and treatment in endodontics, published in 2010 by the Swedish Council on Health Technology Assessment. A questionnaire was mailed to a random subsample of 2012 dental offices where one dentist at each office was requested to answer all questions. Each questionnaire contained one of three sets of questions about endodontic practice routines.Thus around one-third of the subsample received case-specific questions about treating carious exposure. Only general practitioners aged below 70 years were included.The final study sample comprised 412 participants.The dentists were presented with two case scenarios. In Case 1 a 22-year old patient had a deep carious lesion in tooth 36 and in Case 2 a 50-year old patient had a deep carious lesion in tooth 14.The participants were asked to nominate their treatment of choice: pulp capping, partial pulpotomy or pulpectomy. For Case 1, 17 per cent of the respondents selected pulpectomy; the corresponding rate for Case 2 was 47 per cent. Female gender and age group 25-49 years were predictive of selection of less invasive treatment options. However, according to recent guidelines (2011) from the National Board of Health and Wellfare, Swedish dentists are recommended to elect pulpectomy prior to pulp capping/partial pulpotomy when confronted with a tooth having a cariously exposed pulp in adults.
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Recubrimiento de la Pulpa Dental/estadística & datos numéricos , Exposición de la Pulpa Dental/terapia , Pautas de la Práctica en Odontología , Pulpectomía/estadística & datos numéricos , Pulpotomía/estadística & datos numéricos , Adulto , Distribución de Chi-Cuadrado , Femenino , Adhesión a Directriz , Humanos , Modelos Logísticos , Masculino , Persona de Mediana Edad , Pautas de la Práctica en Odontología/estadística & datos numéricos , Obturación del Conducto Radicular/estadística & datos numéricos , Consejos de Especialidades , Encuestas y Cuestionarios , Suecia , Adulto JovenRESUMEN
OBJECTIVE: To evaluate the scientific evidence regarding laser technology for removal of carious tissue. MATERIAL AND METHODS: A search for literature on the effect of treatment and on economic aspects of laser technology identified 23 papers. No relevant studies on economic aspects were found. Regarding the effect of treatment, 16 papers were selected for assessment according to established criteria. RESULTS: Cavity preparation and caries excavation by erbium laser were evaluated in three studies of medium quality. The time required to remove carious tissue was evaluated in five studies assessed as being of medium quality for this outcome. In four studies the effect of laser treatment on the dental pulp was included as an outcome but, due to the short follow-up time, the quality was assessed as low. Two studies that included the longevity of the restoration as an outcome were also assessed as being of low quality because the follow-up time was inadequate. Patient response was evaluated in three studies, which were assessed as being of medium quality with respect to this outcome. CONCLUSIONS: There is limited scientific evidence that laser treatment is as effective as a rotary bur for removing carious tissue. Treatment time is prolonged. There is limited scientific evidence that adults prefer laser treatment. No conclusions can be drawn regarding biological or technical complications, children's perception of laser treatment or the cost-effectiveness of the method.
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Caries Dental/terapia , Terapia por Láser/métodos , Láseres de Estado Sólido/uso terapéutico , Ensayos Clínicos Controlados como Asunto , Preparación de la Cavidad Dental/métodos , Humanos , Factores de Tiempo , Resultado del TratamientoRESUMEN
OBJECTIVE: The aim of this study was to make estimates from a dental care and societal perspective on costs of mandibular third molar surgery. MATERIAL AND METHODS: A total of 64 patients were recruited from three Swedish oral and maxillofacial specialist clinics. Calculations were made prospectively on utilization of labor time, specific medical services and materials, and standardized utilization of other direct costs. Indirect costs were identified from patient surveys. RESULTS: The base case average direct cost of surgery was 217 Euro. Adding the patient's average cost due to absence from work and transportation of 333 Euro increased overall costs to 550 Euro per patient. About 86% of the patients reported some absence following surgery. CONCLUSIONS: The indirect costs were on average higher than the direct costs, i.e. the patient's loss of time caused higher costs than the intervention per se. Appropriate indications for mandibular third molar removal can minimize the risks of complications and individual or societal costs.
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Mandíbula/cirugía , Tercer Molar/cirugía , Extracción Dental/economía , Absentismo , Adolescente , Adulto , Costos y Análisis de Costo/economía , Atención Odontológica/economía , Materiales Dentales/economía , Costos Directos de Servicios , Femenino , Humanos , Masculino , Persona de Mediana Edad , Modelos Económicos , Administración de la Práctica Odontológica/economía , Estudios Prospectivos , Suecia , Factores de Tiempo , Transporte de Pacientes/economía , Adulto JovenRESUMEN
The aim was to calculate the total and the net costs per child included in a 3-year caries preventive program for preschool children and to make estimates of expected lowest and highest costs in a sensitivity analysis. The direct costs for prevention and dental care were applied retrospectively to a comprehensive oral health outreach project for preschool children conducted in a low-socioeconomic multi-cultural urban area. The outcome was compared with historical controls from the same area with conventional dental care. The cost per minute for the various dental professions was added to the cost of materials, rental facilities and equipment based on accounting data. The cost for fillings was extracted from a specified per diem list. Overhead costs were assumed to correspond to 50% of salaries and all costs were calculated as net present value per participating child in the program and expressed in Euro. The results revealed an estimated total cost of 310 Euro per included child (net present value) in the 3-year program. Half of the costs were attributed to the first year of the program and the costs of manpower constituted 45% of the total costs. When the total cost was reduced with the cost of conventional care and the revenue of avoided fillings, the net cost was estimated to 30 Euro. A sensitivity analysis displayed that a net gain could be possible with a maximal outcome of the program. In conclusion, the estimated net costs were displayed and available to those considering implementation of a similar population-based preventive program in areas where preschool children are at high caries risk.
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Atención Dental para Niños/economía , Caries Dental/prevención & control , Odontología Preventiva/economía , Preescolar , Ciudades/etnología , Análisis Costo-Beneficio , Costos y Análisis de Costo , Diversidad Cultural , Humanos , Salud Bucal , Evaluación de Programas y Proyectos de Salud , Factores de Riesgo , Factores Socioeconómicos , Suecia/etnologíaRESUMEN
OBJECTIVE: To evaluate the cost of true-positive occlusal dentine caries detection in permanent molars assessed by: (I) visual-tactile examination, (II) visual-tactile examination combined with bitewing radiographs, and (III) selective radiographic examination of patients with lesions detected clinically. A second aim was to analyse the different strategies when the costs of the subsequent restorative care are considered. METHODS: A model analysis was applied owing to the lack of original articles. Sensitivity and specificity were calculated from a systematic review and included in vitro and in vivo studies of medium and high quality. The direct costs for examinations and restorative care were extracted from the costs of the Public Dental Service in Sweden (2006). RESULTS: The diagnostic costs per true-positive finding were dependent on the occurrence of occlusal caries and increased with decreasing prevalence. The strategy by which radiographs were exposed selectively on the basis of findings from visual-tactile examination resulted in higher initial costs compared with the first and second strategies. When the costs of the subsequent restorative care were added, the selective strategy was most beneficial by up to 26% savings per true-positive diagnosis. However, with this selective strategy, more cases of true-positive dentine caries were assumed would remain undetected as compared with the combined strategy with visual-tactile examination and radiographs for all. CONCLUSIONS: The cost for a true-positive caries diagnosis was inversely related to caries occurrence, and different diagnostic strategies may display contrasting outcomes when subsequent restorative care is taken into account.
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Caries Dental/diagnóstico , Modelos Económicos , Radiografía de Mordida Lateral/economía , Análisis Costo-Beneficio , Caries Dental/diagnóstico por imagen , Caries Dental/economía , Diagnóstico Bucal/economía , Economía en Odontología , Humanos , Examen Físico/economíaAsunto(s)
Dispepsia , Gastroscopía , Helicobacter pylori/aislamiento & purificación , Adulto , Anciano , Análisis Costo-Beneficio , Vías Clínicas , Dispepsia/economía , Dispepsia/microbiología , Dispepsia/terapia , Infecciones por Helicobacter/diagnóstico , Infecciones por Helicobacter/tratamiento farmacológico , Humanos , Persona de Mediana Edad , Atención Primaria de Salud , SueciaRESUMEN
OBJECTIVE: From a dental care perspective, we analyze whether the prevention of approximal caries by fluoride varnish treatment (FVT) or by fluoride mouth rinsing (FMR) could contain costs in an extended period of follow-up after the end of school-based prevention programs. MATERIAL AND METHODS: It is assumed in a model that, after 3 years of prevention with either FVT or FMR according to published studies, the "natural course" of approximal caries progression would follow for 5 consecutive years, as described in a Swedish longitudinal study. The outcome and costs of FVT, FMR and controls were modelled from years 4 to 8. RESULTS: The FVT program had a better outcome in reducing approximal caries than FMR, and costs were lower. The FVT was expected to result in cost containment compared to controls 3 years after the end of the preventive FVT program. The ratio benefits to costs were 1.8: 1 for FVT and 0.9: 1 for FMR. CONCLUSIONS: Prevention of approximal caries by FVT may result in cost containment, at a benefit cost ratio of 1.8: 1, given that the program can be administered at school.
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Cariostáticos/administración & dosificación , Caries Dental/prevención & control , Restauración Dental Permanente/economía , Fluoruros Tópicos/administración & dosificación , Odontología Preventiva/economía , Servicios de Odontología Escolar/economía , Cariostáticos/economía , Niño , Análisis Costo-Beneficio , Árboles de Decisión , Caries Dental/epidemiología , Fluoruros Tópicos/economía , Humanos , Incidencia , Modelos Económicos , Antisépticos Bucales/economía , Fluoruro de Sodio/administración & dosificación , Fluoruro de Sodio/economía , Suecia/epidemiologíaRESUMEN
BACKGROUND: Multiple sclerosis (MS) causes work disability and healthcare resource use, but little is known about the distribution of the associated costs to society. OBJECTIVES: We estimated the cost of illness (COI) of working-aged individuals with MS, from the societal perspective, overall and in different groups. METHODS: A population-based study was conducted, using data linked from several nationwide registers, on 14,077 individuals with MS, aged 20-64 years and living in Sweden. Prevalence-based direct and indirect costs in 2010 were calculated, including costs for prescription drug use, specialized healthcare, sick leave, and disability pension. RESULTS: The estimated COI of all the MS patients were SEK 3950 million, of which 75% were indirect costs. MS was the main diagnosis for resource use, causing 38% of healthcare costs and 67% of indirect costs. The distribution of costs was skewed, in which less than 25% of the patients accounted for half the total COI. CONCLUSIONS: Indirect costs contributed to approximately 75% of the estimated overall COI of MS patients of working age in Sweden. MS was the main diagnosis for more than half of the estimated COI in this patient group. Further studies are needed to gain knowledge on development of costs over time during the MS disease course.
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Costo de Enfermedad , Costos de la Atención en Salud , Esclerosis Múltiple/economía , Ausencia por Enfermedad , Adulto , Femenino , Humanos , Masculino , Persona de Mediana Edad , Pensiones , Suecia/epidemiología , Adulto JovenRESUMEN
The high prevalence of dementia has a great impact on the formal care systems as well as on the situation for informal caregivers. Thus the question of cost effectiveness is crucial. This paper is based on the health-economic portion of the dementia project of the Swedish Council on Technology Assessment in Healthcare. After a database search and quality judgment of papers, 35 papers were included (22 were pharmacoeconomic studies, and 13 focused on programs, such as daycare, caregiver support, and living arrangements). No empirical drug study was regarded as a complete health-economic study. Of the four prospective, randomized, controlled trials, three yielded a nonsignificant difference regarding costs (all for donepezil), whereas there was a significant cost reduction in the Memantine study (favoring Memantine treatment), mainly due to reduction in caregiver time. The majority of the complete pharmacoeconomic modeling studies showed a dominance for drug treatment, indicating cost effectiveness. In conclusion, as regards the cost effectiveness of treatment for Alzheimer's disease, no evidence could be stated in terms of empirical studies, mainly because of a lack of studies. Although most models indicated cost effectiveness, the Swedish Council on Technology Assessment in Healthcare did not regard this as sufficient evidence of cost effectiveness. There is a need for larger and longer empirical studies, and for enlarged sensitivity analyses, in terms of model studies.
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Dolor Musculoesquelético/etiología , Dolor de Cuello/etiología , Enfermedades Profesionales/etiología , Dolor de Hombro/etiología , Trastornos de Traumas Acumulados/etiología , Medicina Basada en la Evidencia , Humanos , Exposición Profesional/efectos adversos , Factores de Riesgo , Carga de Trabajo , Lugar de Trabajo/psicologíaRESUMEN
BACKGROUND: Cost-of-illness (COI) studies of Multiple Sclerosis (MS) are vital components for describing the economic burden of MS, and are frequently used in model studies of interventions of MS. We conducted a systematic review of studies estimating the COI of MS, to compare costs between studies and examine cost drivers, emphasizing generalizability and methodological choices. MATERIAL AND METHOD: A literature search on studies published in English on COI of MS was performed in PubMed for the period January 1969 to January 2014, resulting in 1,326 publications. A mapping of studies using a bottom-up approach or top-down approach, respectively, was conducted for the 48 studies assessed as relevant. In a second analysis, the cost estimates were compared between the 29 studies that used a societal perspective on costs, human capital approach for indirect costs, presenting number of patients included, time-period studied, and year of price level used. RESULTS: The mapping showed that bottom-up studies and prevalence approaches were most common. The cost ratios between different severity levels within studies were relatively stable, to the ratio of 1 to 2 to 3 for disability level categories. Drugs were the main cost drivers for MS-patients with low disease severity, representing 29% to 82% of all costs in this patient group, while the main cost components for groups with more advanced MS symptoms were production losses due to MS and informal care, together representing 17% to 67% of costs in those groups. CONCLUSION: The bottom-up method and prevalence approach dominated in studies of COI of MS. Our findings show that there are difficulties in comparing absolute costs across studies, nevertheless, the relative costs expressed as cost ratios, comparing different severity levels, showed higher resemblance. Costs of drugs were main cost drivers for less severe MS and informal care and production losses for the most severe MS.
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Costo de Enfermedad , Esclerosis Múltiple/economía , HumanosRESUMEN
Our aim was to describe patient flows in mandibular third molar surgery at oral and maxillofacial specialist units. Our hypothesis was that there are variations in how care is delivered and that the variations could be explained by inter-individual variations in surgeons' practice, the quality of the radiographs appended to the referral, and the staffing of the specialist units. A flow chart was constructed to simulate all possible patient flows in the care process. The chart begins with treatment planning, which was drawn up based on documents from the referring dentist or another caregiver; continues with the care process at the oral and maxillofacial surgery unit, including surgical consultations and radiological examinations; and ends with surgery. Surgeons at four oral and maxillofacial surgery units in the National Health Service in southern Sweden participated. The intention was to collect data on at least 100 patients who had undergone mandibular third molar surgery at each unit. Data on 361 patients were collected. The radiographs appended to the referral were judged to be inappropriate for the majority of the patients (61%). For 13% of these patients, supplementary radiographic examinations were made at the radiology clinic included in the unit, whilst 48% were examined at the oral and maxillofacial surgery clinic. There were eight different patient flow patterns. In one unit with three surgeons, eight different flow patterns were recorded, indicating an interindividual variation among the surgeons. In a second unit, six different flow patterns were recorded. In the last two units, the patient flows appeared to be the same at each unit, although the predominant patient flows in these two units differed. The number of patient visits to the specialist units ranged between one and three. In three specialist units, most patients were called twice whilst in one specialist unit most patients were called only once, to have the third molar removed. Differences existed in the care process. Overall, the number of patient visits seemed not to depend on whether the preoperative radiographic examination was judged to be appropriate or whether the additional radiographs were made at the radiology clinic.