The effect of heat-stable extract from bovine sublingual salivary glands on the carbohydrate metabolism of the rabbit.

This extract (SLF3) caused hyperglycaemia when injected intraperitoneally (i.p.) into rabbits (20 mg/kg body wt) which was maximal at 0.5 h and took 2 h to return to the initial value. SLF3 also produced a two-fold increase in corticosteroid levels compared to controls, so the increase in blood glucose was probably mediated by adrenal cortical hormone stimulation.

The effect of heat-stable extract from bovine sublingual salivary gland on serum cholesterol and triglyceride levels in normal and hypercholesterolemic rabbits.

An extract of bovine sublingual glands (SLF3) reduced the serum cholesterol levels of normal rabbits 34.6% and serum triglyceride levels 19.6% when injected intraperitoneally (i.p.) at 20 mg/kg body wt on alternate days for 7 days. SLF3 also reduced serum cholesterol levels 69.0% and triglyceride levels 46.5% in hypercholesterolemic rabbits, while in similar rabbits injected with a control muscle tissue extract, the rate of decrease in serum cholesterol levels was 33.3% and triglyceride levels 26.7%.