RESUMEN
The synthesis of 1,3,3-trimethyl-6-phenyl-2-oxabicyclo[2.2.2]octan-6-ol 2 and 6-benzyl-1,3,3-trimethyl-2-oxabicyclo[2.2.2]octan-6-ol 3 starting from (+)-1,3,3-trimethyl-2-oxabicyclo[2.2.2]octan-6-one and phenylmagnesium bromide or benzylmagnesium chloride, respectively, is described. Alcohols 2 and 3 gave a series of omega-dialkylaminoalkyl ethers 4 by reaction as sodium salts with omega-chloroalkyldialkylamines in toluene solution. Some compounds 4, in particular those derived from alcohol 2, showed a strong platelet antiaggregating activity in vitro, superior to that of acetylsalicylic acid, as well as in general an appreciable local anesthetic activity and a weak sedative effect in mice.
Asunto(s)
Anestésicos Locales/síntesis química , Compuestos Bicíclicos con Puentes/síntesis química , Inhibidores de Agregación Plaquetaria/síntesis química , Anestesia , Anestésicos Locales/farmacología , Animales , Presión Sanguínea/efectos de los fármacos , Compuestos Bicíclicos con Puentes/farmacología , Cloroformo , Humanos , Técnicas In Vitro , Espectroscopía de Resonancia Magnética , Ratones , Actividad Motora/efectos de los fármacos , Agregación Plaquetaria/efectos de los fármacos , Inhibidores de Agregación Plaquetaria/farmacología , Ratas , Espectrofotometría Infrarroja , Fibrilación Ventricular/inducido químicamente , Fibrilación Ventricular/prevención & controlRESUMEN
In their experimental researches the Authors showed that the well-known antihypertensive alpha-adrenergic stimulant drugs (clonidine, flutonidine and guanabenz) were able to antagonize at very high concentrations the platelet aggregation induced by ADP and by thrombin on rabbit PRP.
Asunto(s)
Agonistas alfa-Adrenérgicos/farmacología , Clonidina/farmacología , Guanabenzo/farmacología , Guanidinas/farmacología , Imidazoles/farmacología , Agregación Plaquetaria/efectos de los fármacos , Adenosina Difosfato/antagonistas & inhibidores , Animales , Conejos , Trombina/antagonistas & inhibidores , Toluidinas/farmacologíaRESUMEN
The Authors, thanks to experimental works, have established that piribedil at high concentrations inhibits ADP and thrombin aggregation effect on the rabbit PRP.
Asunto(s)
Piperazinas/farmacología , Piribedil/farmacología , Agregación Plaquetaria/efectos de los fármacos , Adenosina Difosfato/antagonistas & inhibidores , Animales , Ratones , Conejos , Trombina/antagonistas & inhibidoresRESUMEN
The synthesis of three series of 3-acyl-, 3-alkyl- and 3-dialkylaminoacetyl-5,7,7-trimethyl-6-oxa-3-azabicyclo[3.2.2]nonanes, (III), (IV) and (V), respectively, is described. A number of these compounds showed surface anesthesia in rabbits and infiltration anesthesia in mice, and antiarrhythmic activity in guinea pigs and mice, all effects being superior or similar to those of lidocaine. The circulatory, cardiac and respiratory effects in dogs and hens are also described.
Asunto(s)
Anestésicos Locales/síntesis química , Antiarrítmicos/síntesis química , Antihipertensivos/síntesis química , Compuestos Bicíclicos con Puentes/síntesis química , Hidrocarburos Aromáticos con Puentes/síntesis química , Animales , Fenómenos Químicos , Química , Pollos , Femenino , Cobayas , Hemodinámica/efectos de los fármacos , Masculino , Ratones , ConejosRESUMEN
Since we had previously observed the considerable anti-inflammatory activity of imidazo[1,2-a]pyrazine 2-acetic acid, we prepared a series of imidazo[1,2-a]pyrazine derivatives, bearing some substituents on the pyrazine ring and a carboxylic, acetic or alpha-methylacetic moiety on the imidazole ring. These new compounds were tested for antiinflammatory, analgesic, antipyretic and ulcerogenic activities.
Asunto(s)
Antiinflamatorios/síntesis química , Pirazinas/síntesis química , Analgésicos/síntesis química , Animales , Antiinflamatorios/toxicidad , Antiinflamatorios no Esteroideos/síntesis química , Ratones , Pirazinas/farmacología , Pirazinas/toxicidad , Ratas , Úlcera Gástrica/inducido químicamenteRESUMEN
An experimental assessment was made of the analgesic, anti-inflammatory and platelet anticlumping activity of ketoprophene lysine, and its effect on body temperature and prostaglandin synthesis. The drug's pharmacodynamics was very similar to that of ketoprophene and its gastric tolerance was better. It was also well tolerated by the dog joint surfaces and cardiovascular apparatus when given i.m. or i.v., even at doses higher than those advised for man, or when infiltrated in ketoreceptor areas.
Asunto(s)
Antiinflamatorios no Esteroideos , Cetoprofeno/farmacología , Lisina/análogos & derivados , Fenilpropionatos/farmacología , Agregación Plaquetaria/efectos de los fármacos , Prostaglandinas/biosíntesis , Animales , Temperatura Corporal/efectos de los fármacos , Perros , Femenino , Cetoprofeno/análogos & derivados , Lisina/farmacología , Masculino , Malondialdehído/metabolismo , Ratones , Conejos , RatasRESUMEN
Experimental research has shown that inosine in doses of 100-500 mg/kg has a protective effect with respect to various experimentally induced myocardiopathies.
Asunto(s)
Corazón/efectos de los fármacos , Inosina/farmacología , Alanina Transaminasa/análisis , Animales , Aspartato Aminotransferasas/análisis , Columbidae , Creatina Quinasa/análisis , Electrocardiografía , Emetina/farmacología , Cobayas , Isoproterenol/farmacología , L-Lactato Deshidrogenasa/análisis , Masculino , Ratones , Miocardio/análisis , Tamaño de los Órganos/efectos de los fármacos , Ratas , Tiroxina/farmacologíaRESUMEN
In the dog, rat and chick, phosphocreatine-Na has not caused, from an experimental point of view, significative modifications of the cardiovascular- and respiratory-apparatus, of the reactivity of the cardio-regulator centers, of the baroreceptorial carotid-sinus and glomus reactivity, of the gangliar-, muscarinic-, histaminergic-, dopaminergic-, beta-adrenergic- and serotoninergic- vasomotor reactivity; only the vasomotor reactivity of a constrictive-type induced by epinephrine, nor-epinephrine, occlusion of the two common carotid arteries, hypertension and by BaCl2 is moderately reduced. It is interesting to note that the hypotensive response evoked by adenosine was augmented.