Asunto(s)
Aciltransferasas/sangre , Colesterol/metabolismo , Errores Innatos del Metabolismo Lipídico/metabolismo , Errores Innatos del Metabolismo/metabolismo , Fosfolípidos/metabolismo , Triglicéridos/metabolismo , Adulto , Autopsia , Biopsia , Femenino , Humanos , Riñón/patología , Corteza Renal/análisis , Fallo Renal Crónico/cirugía , Glomérulos Renales/análisis , Glomérulos Renales/patología , Trasplante de Riñón , Hígado/análisis , Lisofosfatidilcolinas/análisis , Fosfatidilcolinas/análisis , Fosfatidiletanolaminas/análisis , Fosfatidilinositoles/análisis , Esfingomielinas/análisis , Bazo/análisis , Trasplante HomólogoRESUMEN
Selective renal artery injections of large single doses of the ionic contrast medium metrizoate produced an irregular nephrographic phase, 'patchy contrast medium retention', in 14 of 16 dogs. The irregular nephrographic phase was associated with a transient accumulation of platelets and fibrinogen in the kidney and with microscopically demonstrable transient thrombi in afferent arterioles and glomerular capillary tufts. These effects were followed by tubular damage, which was demonstrated in 4 of 6 dogs examined 48 hours after injection. Formation of thrombi was not demonstrated in 6 dogs given small single doses, which produced a homogeneous nephrographic phase. It is suggested that contrast medium induced endothelial damage is a pathogenetic mechanism in the development of thrombi and patchy contrast medium retention.
Asunto(s)
Yodobenzoatos , Riñón/diagnóstico por imagen , Ácido Metrizoico , Agregación Plaquetaria/efectos de los fármacos , Animales , Plaquetas , Radioisótopos de Cromo , Perros , Femenino , Fibrinógeno/análisis , Inyecciones Intraarteriales , Riñón/patología , Enfermedades Renales/inducido químicamente , Enfermedades Renales/diagnóstico por imagen , Enfermedades Renales/patología , Masculino , Ácido Metrizoico/administración & dosificación , Ácido Metrizoico/efectos adversos , Radiografía , Arteria RenalRESUMEN
A 25-year-old man presented with severe hypertension associated with hypokalemia, elevated plasma renin level and secondary hyperaldosteronism. Malignant phase hypertension and renal artery stenosis were ruled out, and a preoperative diagnosis of renin-secreting renal tumour was made on the basis of higher concentrations of renin in the left than in the right renal venous plasma in spite of normal findings on selective renal arteriography. By removal of the affected kidney the tumour was found and it had a very high content of renin. Following the operation the plasma renin level, serum aldosterone concentration and BP became normal. We present a histopathological description and an ultrastructural study of the tumour.
Asunto(s)
Hipertensión Renal/complicaciones , Neoplasias Renales/metabolismo , Renina/metabolismo , Adulto , Aldosterona/sangre , Gránulos Citoplasmáticos/ultraestructura , Retículo Endoplásmico/ultraestructura , Humanos , Hiperaldosteronismo/etiología , Aparato Yuxtaglomerular/ultraestructura , Neoplasias Renales/complicaciones , Neoplasias Renales/patología , Masculino , Renina/sangreRESUMEN
A patient with dermatitis herpetiformis, proteinuria and reduced renal function is described. A renal biopsy studied by light and immunofluorescence microscopy revealed a glomerulonephritis with deposits of predominantly IgA and complement C3. Deposits of IgA and C3 were also demonstrated in a biopsy from normal skin, and a common pathway for the skin and renal lesions is suggested.
Asunto(s)
Dermatitis Herpetiforme/complicaciones , Glomerulonefritis/complicaciones , Complemento C3/análisis , Femenino , Técnica del Anticuerpo Fluorescente , Humanos , Inmunoglobulina A/análisis , Riñón/patología , Glomérulos Renales/inmunología , Persona de Mediana Edad , Piel/patologíaRESUMEN
REnal biopsies were performed on 14 patients with active rheumatoid arthritis an proteinuria of whom 7 patients had reduced creatinine clearance. Glomerular hypercellularity was found in six and amyloid in seven biopsies. Immunofluorescence microscopy revealed glomerula deposits of immunoglobulins and complement in 10 of 12 biopsies, indicating an active immunologic process causing the impaired renal function.