RESUMEN
OBJECTIVE: The aim of this retrospective study was to analyze the relationship between detection pattern, tumor thickness, patient demographics, and personal and family history of melanoma in the era of noninvasive diagnosis. METHODS: All patients with primary cutaneous melanoma who presented to the Department of Dermatology at the University of Florence between January 2000 and November 2010 were interviewed at the time of their final histopathological diagnoses of melanoma as part of their clinical record. The treating physician specifically questioned all patients about who had first detected or suspected the lesion that resulted in the histological diagnosis of melanoma. RESULTS: A total of 802 melanoma patients were analyzed. The spouse found approximately 16% of the melanomas, and a similar percentage was discovered by the general practitioner. The largest group of melanomas (36%) was discovered during regular annual skin examinations by dermatologists, while another large group (33%) were discovered by the patients themselves. The data that emerged from our study is that self-detection was associated with a greater probability of having a thick melanoma and, therefore, a poor prognosis (odds ratio 1.56). CONCLUSIONS: Because the current mortality of melanoma is still stable, we are convinced that a new message should be introduced to encourage high-risk patients to have an annual skin examination as a rule.
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Melanoma/diagnóstico , Neoplasias Cutáneas/diagnóstico , Adulto , Anciano , Femenino , Conocimientos, Actitudes y Práctica en Salud , Humanos , Italia , Masculino , Tamizaje Masivo , Persona de Mediana Edad , Estudios Retrospectivos , Factores de Riesgo , Autoexamen/métodos , Pruebas Cutáneas , Factores de TiempoRESUMEN
BACKGROUND: Lightless caves can harbour a wide range of living organisms. Cave animals have evolved a set of morphological, physiological, and behavioural adaptations known as troglomorphisms, enabling their survival in the perpetual darkness, narrow temperature and humidity ranges, and nutrient scarcity of the subterranean environment. In this study, we focused on adaptations of skull shape and sensory systems in the blind cave salamander, Proteus anguinus, also known as olm or simply proteus-the largest cave tetrapod and the only European amphibian living exclusively in subterranean environments. This extraordinary amphibian compensates for the loss of sight by enhanced non-visual sensory systems including mechanoreceptors, electroreceptors, and chemoreceptors. We compared developmental stages of P. anguinus with Ambystoma mexicanum, also known as axolotl, to make an exemplary comparison between cave- and surface-dwelling paedomorphic salamanders. FINDINGS: We used contrast-enhanced X-ray computed microtomography for the 3D segmentation of the soft tissues in the head of P. anguinus and A. mexicanum. Sensory organs were visualized to elucidate how the animal is adapted to living in complete darkness. X-ray microCT datasets were provided along with 3D models for larval, juvenile, and adult specimens, showing the cartilage of the chondrocranium and the position, shape, and size of the brain, eyes, and olfactory epithelium. CONCLUSIONS: P. anguinus still keeps some of its secrets. Our high-resolution X-ray microCT scans together with 3D models of the anatomical structures in the head may help to elucidate the nature and origin of the mechanisms behind its adaptations to the subterranean environment, which led to a series of troglomorphisms.
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Proteidae , Animales , Oscuridad , Urodelos , Rayos XAsunto(s)
Receptor beta de Estrógeno/metabolismo , Melanoma/metabolismo , Perimenopausia/metabolismo , Complicaciones Neoplásicas del Embarazo/metabolismo , Neoplasias Cutáneas/metabolismo , Adulto , Factores de Edad , Progresión de la Enfermedad , Receptor alfa de Estrógeno/metabolismo , Femenino , Humanos , Persona de Mediana Edad , EmbarazoRESUMEN
With the improvement in survival after breast cancer there has been increasing interest in the long-term effects of radiotherapy, including the development of tumours. Compared with the general population, breast cancer survivors have a 10-50% higher risk of developing a second cancer. Radiotherapy may play a role in the onset of such lesions. We describe here the case of a 68-year-old woman who developed synchronous cutaneous angiosarcoma, melanoma and morphea of the breast skin and the local area, 14 years after radiotherapy for breast carcinoma. Given the risk of post-radiation secondary primaries in breast cancer patients, long-term surveillance is necessary, with particular attention being paid to skin changes in the irradiation field. Radiation-induced morphea is a rare complication in which immunological abnormalities may stimulate malignant transformation. Long-term studies are required to clarify the pathogenesis of these rare associations.
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Neoplasias de la Mama/radioterapia , Carcinoma/radioterapia , Hemangiosarcoma/etiología , Melanoma/etiología , Neoplasias Inducidas por Radiación/etiología , Neoplasias Primarias Secundarias/etiología , Esclerodermia Localizada/etiología , Neoplasias Cutáneas/etiología , Anciano , Femenino , Hemangiosarcoma/patología , Humanos , Melanoma/patología , Neoplasias Inducidas por Radiación/patología , Neoplasias Primarias Secundarias/patología , Radioterapia/efectos adversos , Esclerodermia Localizada/patología , Piel/patología , Piel/efectos de la radiación , Neoplasias Cutáneas/patología , Factores de TiempoRESUMEN
Leiomyosarcomas are rare malignant tumors of smooth muscles. Superficial leiomyosarcoma is generally a disease of middle age, most frequently encountered between 40 and 60 years of age. It is usually diagnosed late or misdiagnosed, since it is a very rare tumor of the head and neck. Awareness of the particularly misleading features of this tumor, especially in elderly patients, is important, as delayed diagnosis is correlated with larger size and invasiveness into contiguous structures, which influence the practicability of radical resection. We present the case of an 81-year-old man with cutaneous leiomyosarcoma on the forehead.
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Leiomiosarcoma/diagnóstico , Neoplasias Cutáneas/diagnóstico , Anciano de 80 o más Años , Diagnóstico Diferencial , Frente , Humanos , Inmunohistoquímica , Leiomiosarcoma/patología , Leiomiosarcoma/cirugía , Masculino , Neoplasias Cutáneas/patología , Neoplasias Cutáneas/cirugíaRESUMEN
The decomposition of diversity into within site (α) and between site (ß) components is especially interesting in subterranean communities because of their isolated nature and limited dispersal potential The aquatic epikarst fauna, sampled from water drips in caves affords a unique opportunity to provide comparable, quantitative samples of a portion of the obligate subterranean dwelling fauna in multiple hierarchical levels. We focused on three interrelated questions-(1) what is the spatial pattern of epikarst species diversity; (2) how does species diversity partition between local, and regional components (nested and replacement); and (3) whether epikarst hotspots are subterranean hotspots in general. We analyzed the geographic pattern of species richness of 30 species of obligate subterranean copepods found in 81 drips in Slovenian caves in three karst regions-Alpine, Dinaric, and Isolated. Comparison of Chao1 and observed (Mao-tau) estimates of species richness indicated sampling in most drips was complete, but species accumulation curves indicated roughly half of the sites in the Dinaric karst had not reached an asymptote. Overall, within drip diversity accounted for three species, different drips in a cave another three, different caves in a region six species, and different regions accounted for the remaining 18 species. Sites in the Dinaric karst had much higher species richness than the other sites, which is in agreement with studies of other components of the subterranean fauna. The fauna associated with drips in Zupanova jama (jama = cave), in the east-central Dinaric karst was the richest found. While turnover explained the majority of ß-diversity, nestedness in the form of hotspot drips was important as well. A consequence is that a small number of drips largely determine cave and regional species diversity.
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Biodiversidad , Invertebrados , Animales , Eslovenia , Análisis EspacialRESUMEN
Observational studies consistently show that melanocytic nevus prevalence increases with age and that phenotypic traits are significantly associated with nevus count in children. An observational study of 1,512 children and adolescents from 2010 to 2013 was conducted. Study dermatologists counted the full body, arm, and facial nevi of each participant. Children and their parents were asked to complete a survey to gather data on personal characteristics, pubertal development, and early-life sun exposure. The main aim of the study was to establish pediatric nevus prevalence and its relationship with age, phenotype, sex, menarche, early-life sun exposure, and sun-protection behaviors. Females had a significantly lower nevus count compared with males, but this sex-related difference was significantly modified by menarche. Sun exposure and sun-protection habits were all significantly associated with nevus count; in particular, children who used sunscreen with a sun-protection factor > 30 had a lower nevus count compared with sun-protection factor ≤ 30 sunscreen users. This study shows that sex, menarche status, and sun-protection practices significantly influence nevus count in this pediatric population.
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Conducta del Adolescente , Conducta Infantil , Menarquia , Nevo Pigmentado/prevención & control , Neoplasias Cutáneas/prevención & control , Luz Solar/efectos adversos , Protectores Solares/farmacología , Adolescente , Niño , Preescolar , Estudios Transversales , Femenino , Humanos , Lactante , Recién Nacido , Italia/epidemiología , Masculino , Nevo Pigmentado/epidemiología , Nevo Pigmentado/etiología , Fenotipo , Prevalencia , Estudios Retrospectivos , Factores Sexuales , Neoplasias Cutáneas/epidemiología , Neoplasias Cutáneas/etiología , Quemadura Solar/complicaciones , Quemadura Solar/prevención & control , Encuestas y CuestionariosRESUMEN
Currently, there are no specific clinical and dermoscopic features for diagnosing truly amelanotic plantar melanoma (TAPM). The present study aimed to investigate the dermoscopic features of all clinical variants of TAMPS and to evaluate their histopathological correlations. A retrospective analysis of prospectively collected data was carried out during a 10-year period (2003-2013). We analyzed the clinical data of 1321 patients, who had received a histological diagnosis of melanoma at the Melanoma Unit of the University of Florence. We selected the clinical and dermoscopic images of TAPMs and analyzed the presence of dermoscopic parameters. Incorrect preoperative diagnoses were analyzed to highlight peculiar dermoscopic features of pinkish plantar melanomas, the clinical diagnosis of which is extremely challenging for the dermatologist. Of all 1321 patients, 29 (24%) had TAPMs. Importantly, only 20.7% of patients with TAPMs had a correct preoperative diagnosis of suspicious melanocytic lesion. On the basis of the initial misdiagnosis, TAPMs were categorized as eczema-like, verruca-like, angioma-like lesions. Dermoscopically, all TAPMs showed the presence of a well-defined 'erythematous homogeneous area' with an atypical polymorphous vascular pattern with dotted, globular, and glomerular vessels. Our study highlights a crucial dermoscopic feature of TAPMs, the 'erythematous homogeneous area' that is characteristic of the plantar region, and, to our knowledge and experience, has not been described in nonacral amelanotic melanomas.
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Dermoscopía/métodos , Melanocitos/patología , Melanoma Amelanótico/diagnóstico , Melanoma/diagnóstico , Neoplasias Cutáneas/diagnóstico , Anciano , Diagnóstico Diferencial , Femenino , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Pronóstico , Estudios Prospectivos , Estudios Retrospectivos , Melanoma Cutáneo MalignoRESUMEN
BACKGROUND: Currently, the association between body mass index (BMI) and hormone therapies and Cutaneous Melanoma (CM) development is strongly debated. This study was carried out to assess the association between BMI, hormone therapies, and CM risk. METHODS: The present study is a hospital-based case-control study with 605 consecutive CM patients and 592 controls treated for non-neoplastic conditions at the Department of Dermatology in Florence. The associations of melanoma risk with BMI and hormone therapies were assessed performing unconditional logistic regression to estimate odds ratios (OR) and their 95% confidence intervals, adjusting for potential confounders. RESULTS: We found a significant interaction of BMI with age (P < 0.0001): being overweight significantly increased CM risk among individuals less than 50 years old (OR = 1.85 with 95% CI 1.14-2.94), whereas the association was not significant for individuals over 50 years old (OR = 1.15 with 95% CI 0.77-1.71). For oestrogen therapy, women taking oral contraceptives (OCs)/hormone replacement therapy (HRT) showed a lower CM risk than men (OR = 0.63, 95% CI 0.44-0.89), with risk estimates significantly lower (P < 0.0001) than in non OCs/HRT users, which had an increased risk compared to men (OR = 1.81, 95% CI 1.29-2.53). CONCLUSIONS: Being overweight was significantly associated with CM risk, and this relationship was highly age-conditioned; the second finding was the protective effect of oestrogen therapies for women. Both findings may have a significant impact on melanoma prevention, as the prevalence of obesity and hormone therapy use is increasing worldwide.
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Terapia de Reemplazo de Hormonas , Melanoma/epidemiología , Sobrepeso/complicaciones , Neoplasias Cutáneas/epidemiología , Adulto , Anciano , Índice de Masa Corporal , Estudios de Casos y Controles , Femenino , Humanos , Masculino , Melanoma/complicaciones , Persona de Mediana Edad , Oportunidad Relativa , Sobrepeso/epidemiología , Prevalencia , Factores de Riesgo , Neoplasias Cutáneas/complicaciones , Melanoma Cutáneo MalignoAsunto(s)
Escisión del Ganglio Linfático , Melanoma/mortalidad , Recurrencia Local de Neoplasia/prevención & control , Biopsia del Ganglio Linfático Centinela , Neoplasias Cutáneas/mortalidad , Humanos , Metástasis Linfática , Melanoma/patología , Melanoma/cirugía , Recurrencia Local de Neoplasia/patología , Recurrencia Local de Neoplasia/cirugía , Estadificación de Neoplasias , Pronóstico , Neoplasias Cutáneas/patología , Neoplasias Cutáneas/cirugíaAsunto(s)
Conocimientos, Actitudes y Práctica en Salud , Melanoma/prevención & control , Neoplasias Cutáneas/prevención & control , Luz Solar/efectos adversos , Adolescente , Niño , Humanos , Italia , Masculino , Melanoma/etiología , Prevención Primaria/organización & administración , Instituciones Académicas/estadística & datos numéricos , Neoplasias Cutáneas/etiología , Estudiantes/estadística & datos numéricos , Protectores Solares/administración & dosificación , Encuestas y CuestionariosRESUMEN
INTRODUCTION: The diagnosis of cutaneous pigmented lesions remains a challenge for both dermatologists and pathologists. Our aim was to determine the diagnostic concordance between the conventional face-to-face diagnosis and the telediagnosis of 10 dermatologists with expertise in dermato-oncology of 10 challenging pigmented lesions. METHODS: Using a store-and-forward teledermatology method, clinical and dermoscopic digital images of all selected lesions were transmitted via e-mail to 10 dermatologists. Dermatologists were called to provide their telediagnoses with a step-by-step approach. When the dermatologists responded with their first clinical telediagnosis, they received a second email that contained dermoscopic images of the 10 cases. Final histopathological diagnosis was considered the gold standard for comparison with face-to-face and teledermatology diagnoses in statistical analysis. RESULTS: Face-to-face results indicated moderate agreement between clinical and histopathological diagnoses (K = 0.6). After the first clinical step, interobserver concordance of telediagnosis was lower than face-to-face diagnosis (K = 0.52). After the second dermoscopy step, the concordance declined further (K = 0.38). CONCLUSIONS: Teledermatology was inferior to face-to-face dermatology. Moreover, the diagnostic concordance of telediagnosis decreased after the teledermoscopic step. This finding may be justified by the dermoscopic difficulty of the selected lesions, including Spitzoid proliferations and atypical melanocytic nevi of the elderly. These lesions may represent a potential diagnostic pitfall given their confounding dermoscopic aspects.
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Dermoscopía , Melanoma/diagnóstico por imagen , Nevo de Células Epitelioides y Fusiformes/diagnóstico por imagen , Neoplasias Cutáneas/diagnóstico por imagen , Telemedicina , Adulto , Anciano , Femenino , Humanos , Masculino , Melanoma/patología , Persona de Mediana Edad , Nevo de Células Epitelioides y Fusiformes/patología , Variaciones Dependientes del Observador , Visita a Consultorio Médico , Neoplasias Cutáneas/patologíaRESUMEN
To assess the patient's capability of performing a correct skin-check examination we investigated the association of melanoma detection pattern with Breslow thickness, by melanoma body area. In this prospective observational study, patients with primary cutaneous melanoma who presented at the Department of Dermatology at the University of Florence between January 2000 and November 2011 were interviewed as part of their clinical data recording procedure at the time of their final histopathological diagnoses of melanoma. With the aim of evaluating a self skin-check, we included patients with melanoma in the anterior part of the trunk (abdomen and chest area), which is generally considered visible in the mirror, and the posterior part of the trunk, which is a more complex area to be self-checked. The treating physician specifically questioned all patients about who had first detected or suspected the lesion that resulted in the histological diagnosis of melanoma in order to compare those who had self-detected (SD) their melanoma with those who had discovered their melanoma during a regular skin-check (RSC) with a dermatologist. A total of 186 melanoma patients were analyzed, with 67% (n=125) of melanomas located on the back and 33% (n=61) in the chest and abdominal area; the majority (55%, n=103) were in the SD group. The median Breslow thickness of the SD group was significantly greater than that of the RSC group: 0.60 versus 0.50 mm (P<0.0001). In the posterior trunk, the frequency of thick melanomas (Breslow≥1.00 mm) was significantly greater in the SD group than in the RSC group (34 vs. 11%; P=0.003), whereas there was no difference in the frequency of thick melanoma by detection patterns in the anterior trunk. Given the influence of the body area in detecting threatening melanoma, we should encourage people to obtain dermatological skin-checks more often. Skin self-examinations cannot be sufficiently accurate.
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Melanoma/diagnóstico , Autoexamen , Neoplasias Cutáneas/diagnóstico , Estudios de Cohortes , Femenino , Humanos , Modelos Logísticos , Masculino , Melanoma/patología , Persona de Mediana Edad , Estudios Prospectivos , Neoplasias Cutáneas/patología , Torso , Carga TumoralAsunto(s)
Dermoscopía , Recurrencia Local de Neoplasia/patología , Neoplasias Cutáneas/secundario , Neoplasias de la Tiroides/patología , Anciano de 80 o más Años , Eritema/etiología , Humanos , Inmunohistoquímica , Neoplasias Pulmonares/secundario , Masculino , Neoplasias Cutáneas/irrigación sanguínea , Neoplasias Cutáneas/patología , Neoplasias de la Tiroides/cirugía , Tiroidectomía , Factores de TiempoRESUMEN
Excess body weight has been shown to increase the risk for development of several common cancers, such as postmenopausal breast, colon, endometrium, kidney, and esophagus cancers. The main aim of the present study was to investigate the potential relationship between excess body weight, assessed in terms of BMI, and Breslow thickness in 605 patients affected by primary cutaneous melanoma. Particularly, we evaluated the occurrence of thick melanoma (>1 mm) in overweight compared with nonoverweight patients. The effect of BMI (≥25 vs. <25 kg/m2) on the risk of having a diagnosis of thick melanoma was estimated in terms of odds ratio (OR) by logistic regression analysis, adjusted for age, sex, and histological type. Significant differences in overweight versus nonoverweight patients were found with respect to sex distribution. In fact, the occurrence of thick melanoma was greater in overweight women than in nonoverweight women (OR=1.64). When the analysis was restricted to postmenopausal women, the corresponding OR increased further to 2.50. In conclusion, a positive association between excess body weight and the risk of thick melanoma was found only in female patients. On stratifying patients into subgroups, the relationship between the risk of being diagnosed with a thick melanoma (>1.0 mm) and overweight status (BMI≥25 kg/m2) was significantly affected by both sex and menopausal status. Despite limitations because of both the study design and the relatively small numbers of patients in certain subgroups, overweight status may be associated with an increased Breslow thickness in postmenopausal women.
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Peso Corporal/fisiología , Melanoma/epidemiología , Sobrepeso/epidemiología , Neoplasias Cutáneas/epidemiología , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Índice de Masa Corporal , Femenino , Humanos , Masculino , Melanoma/patología , Persona de Mediana Edad , Sobrepeso/complicaciones , Estudios Retrospectivos , Piel/patología , Neoplasias Cutáneas/patología , Carga Tumoral , Adulto JovenAsunto(s)
Inhibidor p16 de la Quinasa Dependiente de Ciclina/genética , Melanoma/epidemiología , Melanoma/genética , Mutación/genética , Neoplasias Primarias Múltiples/epidemiología , Neoplasias Cutáneas/epidemiología , Neoplasias Cutáneas/genética , Adulto , Estudios de Casos y Controles , Demografía , Femenino , Humanos , Masculino , Melanoma/patología , Persona de Mediana Edad , Neoplasias Primarias Múltiples/patología , Pronóstico , Neoplasias Cutáneas/patologíaRESUMEN
BACKGROUND: The diagnosis of squamous cell carcinoma (SCC) is, generally, a clinical diagnosis, but in some cases, when the lesion is pigmented, as in our case, the differential diagnosis between pigmented SCC and other pigmented skin lesions, in particular melanocytic lesions, is difficult. Dermoscopy may improve the early diagnosis of SCC and thus play a role in its preoperative classification. However, its potential role has been hampered so far by the fact that little is known about the dermoscopic features of pigmented SCC. OBJECTIVE: We report the case of a rare pigmented SCC dermoscopically mimicking a melanocytic lesion whose dermoscopic features have been investigated. CONCLUSION: On the basis of the literature and our experience, pigmented SCC can present dermoscopic features typical of melanocytic lesions, such as radial streaks, globules, and homogeneous blue pigmentation, and can lead dermatologists to diagnostic errors.