[Clinical and biochemical syndromes of cadmium-induced acute porphyrinopathy].

AIM: To study the specific features of porphyrin metabolic disturbances in cadmium poisoning. MATERIAL AND METHODS: The paper describes a patient who has developed clinical and biochemical syndromes of acute porphyrinopathy after exposure to cadmium-containing paint the vapors. The levels of delta-aminolevulinic acid, porphobilinogen, coproporphyrin, and uroporphyrin in urine and those of coproporphyrin and protoporphyrin in feces were measured. The concentrations of lead, cadmium, and copper were determined in whole blood and urine; selective screening of amino acids for hereditary metabolic diseases was made. RESULTS: The clinical signs of acute porphyrinopathy developed in the patient mimicked those of acute porphyries known by the current classification. The biochemical syndrome more corresponded to lead poisoning. However, the blood and urinary lead levels were not greater than the normal values, but the blood showed a 4-fold increase in cadmium, which seemed to induce porphyrin dysmetabolism.

[The prognosis of the course and outcome of small-focus myocardial infarct depending on the T-index values on the ECG based on data from the Novosibirsk Myocardial Infarct Registry program]. / Prognozirovanie techeniia i iskhodov melkoochagovogo infarkta miokarda v zavisimosti ot velichin T-pokazatelia na EKG po materialam programmy "Registr infarkta miokarda" Novosibirska.

Overall 342 patients with small-focal myocardial infarction were analyzed for hospital complications and for outcomes during one- and four-year observation periods in groups with different magnitudes of the T parameter. The latter one is the negative T wave on the ECG computed similarly to the Z. L. Dolabchian's index for Q and R waves on days 1-2 and 28 of myocardial infarction. The use of the T parameter allows predicting the most frequently occurring complications during the hospital observation period and recurrent myocardial infarction and cardial death during the period indicated. In the acute stage, the magnitudes of the T parameter from 1 to 24 conventional units are predictors of the complications: lung edema, cardiogenic shock, rhythm disorders, myocardial infarction relapses, particularly in able-bodied men. If the T parameter amounts from 78 to 648 conventional units in the acute stage and on day 28, this suggests a high risk of repeated myocardial infarction and cardial death for one- and 4-year observation periods in accordance with materials of the "Myocardial Infarction Register" program in Novosibirsk.