[Clinico-immunologic evaluation of the sequelae of closed craniocerebral injuries]. / Kliniko-immunologicheskaia otsenka posledstvii zakrytoi cherepno-mozgovoi travmy.

Sixty-four patients were examined clinically and immunologically at a long-term period following craniocerebral trauma. In patients with a history of head trauma impaired adaptation mechanisms were shown to underlie the neurologic disorders, which was reflected in changes in the natural immunity system. The severity and duration of natural resistance impairments were correlated with the gravity of clinical manifestations. The study of the time-course of natural resistance parameters allows the objective evaluation of the degree of central nervous system recovery following closed craniocerebral trauma.

[Immunologic study of cerebrospinal fluid in the diagnosis of posttraumatic meningitis]. / Immunologicheskoe issledovanie spinomozgovoi zhidkosti v diagnostike posttravmaticheskogo meningita.

Immunological examination of the cerebrospinal fluid (CSF) in 280 patients in the acute period of craniocerebral trauma demonstrated an increase in the beta-lysin content and lysozyme concentration in it when meningitis developed. Increase in the CSF beta lytic and lysozyme activity reflects the severity of the inflammatory process. Tests for these factors in the CSF may be used in the early diagnosis of post-traumatic meningitis.

[State of non-specific immunoreactivity in patients with closed cranio-cerebral trauma]. / Sostoianie nespetsificheskoi immunoreaktivnosti u bol'nykh s zakrytoi cherepno-mozgovoi travmoi.

Studies of the state of the non-specific humoral protection in 138 patients with craniocerebral injuries demonstrated that the bactericidal and beta-lytic activity of the serum remains relatively stable during the acute period of trauma, while the complement activity and the concentration of lysozyme are subject to significant alterations. The elevation of the lysozyme content and the enhancement of the complement activity are in direct proportion with the severity of the injury, and are revealed at the peak of the acute period of the craniocerebral trauma.

[Various adaptive responses of patients with combined cranio-cerebral injuries]. / O nekotorykh adaptatsionnykh reaktsiiakh bol'nykh s sochetannoi cherepno-mozgovoi travmoi.

Clinical and immunologic study of 100 patients with combined and 320 patients with isolated craniocerebral injury showed that disorders of body reactivity occur in the acute period of polytrauma. The disorders may be compensated, subcompensated and decompensated. The surgical tactics and treatment of patients should be planned with due account for the person's general reactivity, as a result of which treatment will be individualized and applied in an adequate volume and optimum time. Tests for natural humoral immunity are suggested as criteria of the reactivity dynamics.

Effect of naloxone hydrochloride on osteogenesis in chick embryos.

Naloxone hydrochloride, an opioid receptors blocker, was administered to chick embryos. Morphological analysis of femoral bones of embryos showed an appreciable increase in the thickness of the perichondral bone cuff in the tubular bone diaphyses and increased mitotic activity in the zone of proliferating young cartilage of the epiphyseal plate.