RESUMEN
Reaferon administered to outbred young mice with experimental influenza had a positive effect on morphologic changes in pulmonary tissues and on lipid peroxidation in the blood plasma and pulmonary tissues. Combined use of reaferon and alpha-tocopherol in mice infected with influenza A virus reduced the mortality rate, boosted the antiviral effect of reaferon proper, and led to virtually complete normalization of lipid peroxidation processes in the blood plasma and pulmonary tissues.
Asunto(s)
Virus de la Influenza A/efectos de los fármacos , Interferón Tipo I/farmacología , Peroxidación de Lípido/efectos de los fármacos , Infecciones por Orthomyxoviridae/metabolismo , Vitamina E/farmacología , Animales , Antivirales/farmacología , Interferón alfa-2 , Interferón-alfa , Ratones , Infecciones por Orthomyxoviridae/virología , Proteínas RecombinantesRESUMEN
Lipid peroxidation as well as effects of various interferons (native, from fibroblasts of new born and adult animals) on the peroxidation were studied in blood plasma, erythrocytes, liver and kidney tissues of mice with viral infection. These interferons, simultaneously with antiviral action, exhibited the positive effect on lipid peroxidation, while the interferon from fibroblasts of newborns produced the side reactions. Simultaneous use of the interferon and alpha-tocopherol removed these side reactions.
Asunto(s)
Interferones/farmacología , Peroxidación de Lípido/efectos de los fármacos , Infecciones por Orthomyxoviridae/metabolismo , Vitamina E/farmacología , Animales , Virus de la Influenza A , Malondialdehído/sangre , Ratones , Infecciones por Orthomyxoviridae/terapiaRESUMEN
Summary. Altogether 187 young children presenting with acute respiratory viral infection were examined for lipid peroxidation and antioxidant defense. The principles of the pathogenetically validated antioxidant treatment are discussed.